Piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis

Manipulation of the pancreas during surgery can induce acute pancreatitis due to zymogen activation. Here the authors show that the mechanoreceptor Piezo1 is activated by pressure and its activation leads to calcium dependent pancreatic injury whereas its inhibition is protective against pancreatiti...

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Autores principales:	Joelle M.-J. Romac, Rafiq A. Shahid, Sandip M. Swain, Steven R. Vigna, Rodger A. Liddle
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/10e1a87d36af415ca7fb7de77dc16ef2
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spelling	oai:doaj.org-article:10e1a87d36af415ca7fb7de77dc16ef22021-12-02T14:41:07ZPiezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis10.1038/s41467-018-04194-92041-1723https://doaj.org/article/10e1a87d36af415ca7fb7de77dc16ef22018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04194-9https://doaj.org/toc/2041-1723Manipulation of the pancreas during surgery can induce acute pancreatitis due to zymogen activation. Here the authors show that the mechanoreceptor Piezo1 is activated by pressure and its activation leads to calcium dependent pancreatic injury whereas its inhibition is protective against pancreatitis.Joelle M.-J. RomacRafiq A. ShahidSandip M. SwainSteven R. VignaRodger A. LiddleNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joelle M.-J. Romac Rafiq A. Shahid Sandip M. Swain Steven R. Vigna Rodger A. Liddle Piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis
description	Manipulation of the pancreas during surgery can induce acute pancreatitis due to zymogen activation. Here the authors show that the mechanoreceptor Piezo1 is activated by pressure and its activation leads to calcium dependent pancreatic injury whereas its inhibition is protective against pancreatitis.
format	article
author	Joelle M.-J. Romac Rafiq A. Shahid Sandip M. Swain Steven R. Vigna Rodger A. Liddle
author_facet	Joelle M.-J. Romac Rafiq A. Shahid Sandip M. Swain Steven R. Vigna Rodger A. Liddle
author_sort	Joelle M.-J. Romac
title	Piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis
title_short	Piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis
title_full	Piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis
title_fullStr	Piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis
title_full_unstemmed	Piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis
title_sort	piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/10e1a87d36af415ca7fb7de77dc16ef2
work_keys_str_mv	AT joellemjromac piezo1isamechanicallyactivatedionchannelandmediatespressureinducedpancreatitis AT rafiqashahid piezo1isamechanicallyactivatedionchannelandmediatespressureinducedpancreatitis AT sandipmswain piezo1isamechanicallyactivatedionchannelandmediatespressureinducedpancreatitis AT stevenrvigna piezo1isamechanicallyactivatedionchannelandmediatespressureinducedpancreatitis AT rodgeraliddle piezo1isamechanicallyactivatedionchannelandmediatespressureinducedpancreatitis
_version_	1718389974705897472

Piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis

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