Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington’s disease

Huntington’s disease (HD) is caused by misfolding of mutant Htt protein. The authors find that in HD models, the decreased expression of heat shock transcription factor 1 that usually protects against protein misfolding, is in part caused by elevated CK2α’ kinase and Fbxw7 E3 ligase expression.

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Autores principales:	Rocio Gomez-Pastor, Eileen T. Burchfiel, Daniel W. Neef, Alex M. Jaeger, Elisa Cabiscol, Spencer U. McKinstry, Argenia Doss, Alejandro Aballay, Donald C. Lo, Sergey S. Akimov, Christopher A. Ross, Cagla Eroglu, Dennis J. Thiele
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/10e213fe581949ff9cd3a516b23f2861
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spelling	oai:doaj.org-article:10e213fe581949ff9cd3a516b23f28612021-12-02T14:40:46ZAbnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington’s disease10.1038/ncomms144052041-1723https://doaj.org/article/10e213fe581949ff9cd3a516b23f28612017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14405https://doaj.org/toc/2041-1723Huntington’s disease (HD) is caused by misfolding of mutant Htt protein. The authors find that in HD models, the decreased expression of heat shock transcription factor 1 that usually protects against protein misfolding, is in part caused by elevated CK2α’ kinase and Fbxw7 E3 ligase expression.Rocio Gomez-PastorEileen T. BurchfielDaniel W. NeefAlex M. JaegerElisa CabiscolSpencer U. McKinstryArgenia DossAlejandro AballayDonald C. LoSergey S. AkimovChristopher A. RossCagla ErogluDennis J. ThieleNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rocio Gomez-Pastor Eileen T. Burchfiel Daniel W. Neef Alex M. Jaeger Elisa Cabiscol Spencer U. McKinstry Argenia Doss Alejandro Aballay Donald C. Lo Sergey S. Akimov Christopher A. Ross Cagla Eroglu Dennis J. Thiele Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington’s disease
description	Huntington’s disease (HD) is caused by misfolding of mutant Htt protein. The authors find that in HD models, the decreased expression of heat shock transcription factor 1 that usually protects against protein misfolding, is in part caused by elevated CK2α’ kinase and Fbxw7 E3 ligase expression.
format	article
author	Rocio Gomez-Pastor Eileen T. Burchfiel Daniel W. Neef Alex M. Jaeger Elisa Cabiscol Spencer U. McKinstry Argenia Doss Alejandro Aballay Donald C. Lo Sergey S. Akimov Christopher A. Ross Cagla Eroglu Dennis J. Thiele
author_facet	Rocio Gomez-Pastor Eileen T. Burchfiel Daniel W. Neef Alex M. Jaeger Elisa Cabiscol Spencer U. McKinstry Argenia Doss Alejandro Aballay Donald C. Lo Sergey S. Akimov Christopher A. Ross Cagla Eroglu Dennis J. Thiele
author_sort	Rocio Gomez-Pastor
title	Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington’s disease
title_short	Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington’s disease
title_full	Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington’s disease
title_fullStr	Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington’s disease
title_full_unstemmed	Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington’s disease
title_sort	abnormal degradation of the neuronal stress-protective transcription factor hsf1 in huntington’s disease
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/10e213fe581949ff9cd3a516b23f2861
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Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington’s disease

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