Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington’s disease

Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington’s disease

Huntington’s disease (HD) is caused by misfolding of mutant Htt protein. The authors find that in HD models, the decreased expression of heat shock transcription factor 1 that usually protects against protein misfolding, is in part caused by elevated CK2α’ kinase and Fbxw7 E3 ligase expression.

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Autores principales: Rocio Gomez-Pastor, Eileen T. Burchfiel, Daniel W. Neef, Alex M. Jaeger, Elisa Cabiscol, Spencer U. McKinstry, Argenia Doss, Alejandro Aballay, Donald C. Lo, Sergey S. Akimov, Christopher A. Ross, Cagla Eroglu, Dennis J. Thiele
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
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Acceso en línea:https://doaj.org/article/10e213fe581949ff9cd3a516b23f2861
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https://doaj.org/article/10e213fe581949ff9cd3a516b23f2861

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