Structural basis for recognition of 53BP1 tandem Tudor domain by TIRR

The p53-binding protein 1 (53BP1) regulates the choice of the DNA double-strand break repair pathway. Here the authors present the crystal structure of Tudor-interacting repair regulator (TIRR) bound to the 53BP1 tandem Tudor domain, which reveals how TIRR blocks H4K20me2 binding to 53BP1 Tudor and...

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Autores principales:	Yaxin Dai, Aili Zhang, Shan Shan, Zihua Gong, Zheng Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/10e5474c6f744b3e827891e12f49cc88
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spelling	oai:doaj.org-article:10e5474c6f744b3e827891e12f49cc882021-12-02T15:34:17ZStructural basis for recognition of 53BP1 tandem Tudor domain by TIRR10.1038/s41467-018-04557-22041-1723https://doaj.org/article/10e5474c6f744b3e827891e12f49cc882018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04557-2https://doaj.org/toc/2041-1723The p53-binding protein 1 (53BP1) regulates the choice of the DNA double-strand break repair pathway. Here the authors present the crystal structure of Tudor-interacting repair regulator (TIRR) bound to the 53BP1 tandem Tudor domain, which reveals how TIRR blocks H4K20me2 binding to 53BP1 Tudor and functionally differs from its paralog Nudt16.Yaxin DaiAili ZhangShan ShanZihua GongZheng ZhouNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yaxin Dai Aili Zhang Shan Shan Zihua Gong Zheng Zhou Structural basis for recognition of 53BP1 tandem Tudor domain by TIRR
description	The p53-binding protein 1 (53BP1) regulates the choice of the DNA double-strand break repair pathway. Here the authors present the crystal structure of Tudor-interacting repair regulator (TIRR) bound to the 53BP1 tandem Tudor domain, which reveals how TIRR blocks H4K20me2 binding to 53BP1 Tudor and functionally differs from its paralog Nudt16.
format	article
author	Yaxin Dai Aili Zhang Shan Shan Zihua Gong Zheng Zhou
author_facet	Yaxin Dai Aili Zhang Shan Shan Zihua Gong Zheng Zhou
author_sort	Yaxin Dai
title	Structural basis for recognition of 53BP1 tandem Tudor domain by TIRR
title_short	Structural basis for recognition of 53BP1 tandem Tudor domain by TIRR
title_full	Structural basis for recognition of 53BP1 tandem Tudor domain by TIRR
title_fullStr	Structural basis for recognition of 53BP1 tandem Tudor domain by TIRR
title_full_unstemmed	Structural basis for recognition of 53BP1 tandem Tudor domain by TIRR
title_sort	structural basis for recognition of 53bp1 tandem tudor domain by tirr
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/10e5474c6f744b3e827891e12f49cc88
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_version_	1718386883943202816

Structural basis for recognition of 53BP1 tandem Tudor domain by TIRR

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