Serotype specific epitopes identified by neutralizing antibodies underpin immunogenic differences in Enterovirus B

So far no vaccine or antiviral therapy is available for Echovirus 30 (E30) that causes aseptic meningitis. Here, the authors generate and characterise two E30-specific monoclonal antibodies that block binding of the virus to its attachment receptor CD55 and uncoating receptor FcRn, and determine the...

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Autores principales:	Kang Wang, Binyang Zheng, Li Zhang, Lunbiao Cui, Xuan Su, Qian Zhang, Zhenxi Guo, Yu Guo, Wei Zhang, Ling Zhu, Fengcai Zhu, Zihe Rao, Xiangxi Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/10e58d8f4c94489ea275a5e358714a16
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spelling	oai:doaj.org-article:10e58d8f4c94489ea275a5e358714a162021-12-02T15:25:36ZSerotype specific epitopes identified by neutralizing antibodies underpin immunogenic differences in Enterovirus B10.1038/s41467-020-18250-w2041-1723https://doaj.org/article/10e58d8f4c94489ea275a5e358714a162020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18250-whttps://doaj.org/toc/2041-1723So far no vaccine or antiviral therapy is available for Echovirus 30 (E30) that causes aseptic meningitis. Here, the authors generate and characterise two E30-specific monoclonal antibodies that block binding of the virus to its attachment receptor CD55 and uncoating receptor FcRn, and determine the cryo-EM structures of E30 with the bound neutralizing antibodies.Kang WangBinyang ZhengLi ZhangLunbiao CuiXuan SuQian ZhangZhenxi GuoYu GuoWei ZhangLing ZhuFengcai ZhuZihe RaoXiangxi WangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kang Wang Binyang Zheng Li Zhang Lunbiao Cui Xuan Su Qian Zhang Zhenxi Guo Yu Guo Wei Zhang Ling Zhu Fengcai Zhu Zihe Rao Xiangxi Wang Serotype specific epitopes identified by neutralizing antibodies underpin immunogenic differences in Enterovirus B
description	So far no vaccine or antiviral therapy is available for Echovirus 30 (E30) that causes aseptic meningitis. Here, the authors generate and characterise two E30-specific monoclonal antibodies that block binding of the virus to its attachment receptor CD55 and uncoating receptor FcRn, and determine the cryo-EM structures of E30 with the bound neutralizing antibodies.
format	article
author	Kang Wang Binyang Zheng Li Zhang Lunbiao Cui Xuan Su Qian Zhang Zhenxi Guo Yu Guo Wei Zhang Ling Zhu Fengcai Zhu Zihe Rao Xiangxi Wang
author_facet	Kang Wang Binyang Zheng Li Zhang Lunbiao Cui Xuan Su Qian Zhang Zhenxi Guo Yu Guo Wei Zhang Ling Zhu Fengcai Zhu Zihe Rao Xiangxi Wang
author_sort	Kang Wang
title	Serotype specific epitopes identified by neutralizing antibodies underpin immunogenic differences in Enterovirus B
title_short	Serotype specific epitopes identified by neutralizing antibodies underpin immunogenic differences in Enterovirus B
title_full	Serotype specific epitopes identified by neutralizing antibodies underpin immunogenic differences in Enterovirus B
title_fullStr	Serotype specific epitopes identified by neutralizing antibodies underpin immunogenic differences in Enterovirus B
title_full_unstemmed	Serotype specific epitopes identified by neutralizing antibodies underpin immunogenic differences in Enterovirus B
title_sort	serotype specific epitopes identified by neutralizing antibodies underpin immunogenic differences in enterovirus b
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/10e58d8f4c94489ea275a5e358714a16
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Serotype specific epitopes identified by neutralizing antibodies underpin immunogenic differences in Enterovirus B

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