Diet, the Gut Microbiome and Heart Failure

The collection of microorganisms that live in coexistence within or on the host body has been referred to as the microbiota. In humans, such cohabitation is mostly seen in the gut, mainly in the colon. The gut microbiome is acquired from the environment and is modified mostly by the diet. There are...

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Autor principal:	Sivadasanpillai Harikrishnan
Formato:	article
Lenguaje:	EN
Publicado:	Radcliffe Medical Media 2019
Materias:	Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/10e8e855d462419d8bd763b89a014803
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id	oai:doaj.org-article:10e8e855d462419d8bd763b89a014803
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spelling	oai:doaj.org-article:10e8e855d462419d8bd763b89a0148032021-12-04T16:01:38ZDiet, the Gut Microbiome and Heart Failure10.15420/cfr.2018.39.22057-75592057-7540https://doaj.org/article/10e8e855d462419d8bd763b89a0148032019-05-01T00:00:00Zhttps://www.cfrjournal.com/articles/diet-gut-microbiome-and-heart-failurehttps://doaj.org/toc/2057-7540https://doaj.org/toc/2057-7559The collection of microorganisms that live in coexistence within or on the host body has been referred to as the microbiota. In humans, such cohabitation is mostly seen in the gut, mainly in the colon. The gut microbiome is acquired from the environment and is modified mostly by the diet. There are preliminary data to show that gut microbia can directly influence the pathogenetic disease processes in heart failure (HF). HF leads to bowel wall oedema and regional hypoxia, causing a change in the microbial flora of the gut, which can initiate or perpetuate certain pathogenetic process in HF. The structural component of the microbiota itself, such as lipopolysaccharides or the substances produced by the bacteria, such as trimethylamine N-oxide, is implicated in the pathogenesis of HF. This process is termed as the ‘heart–gut axis’ in HF. Manipulating the gut microbia or targeting products from the microbia may become treatment options for HF in future.Sivadasanpillai HarikrishnanRadcliffe Medical MediaarticleDiseases of the circulatory (Cardiovascular) systemRC666-701ENCardiac Failure Review , Vol 5, Iss 2, Pp 119-122 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Diseases of the circulatory (Cardiovascular) system RC666-701 Sivadasanpillai Harikrishnan Diet, the Gut Microbiome and Heart Failure
description	The collection of microorganisms that live in coexistence within or on the host body has been referred to as the microbiota. In humans, such cohabitation is mostly seen in the gut, mainly in the colon. The gut microbiome is acquired from the environment and is modified mostly by the diet. There are preliminary data to show that gut microbia can directly influence the pathogenetic disease processes in heart failure (HF). HF leads to bowel wall oedema and regional hypoxia, causing a change in the microbial flora of the gut, which can initiate or perpetuate certain pathogenetic process in HF. The structural component of the microbiota itself, such as lipopolysaccharides or the substances produced by the bacteria, such as trimethylamine N-oxide, is implicated in the pathogenesis of HF. This process is termed as the ‘heart–gut axis’ in HF. Manipulating the gut microbia or targeting products from the microbia may become treatment options for HF in future.
format	article
author	Sivadasanpillai Harikrishnan
author_facet	Sivadasanpillai Harikrishnan
author_sort	Sivadasanpillai Harikrishnan
title	Diet, the Gut Microbiome and Heart Failure
title_short	Diet, the Gut Microbiome and Heart Failure
title_full	Diet, the Gut Microbiome and Heart Failure
title_fullStr	Diet, the Gut Microbiome and Heart Failure
title_full_unstemmed	Diet, the Gut Microbiome and Heart Failure
title_sort	diet, the gut microbiome and heart failure
publisher	Radcliffe Medical Media
publishDate	2019
url	https://doaj.org/article/10e8e855d462419d8bd763b89a014803
work_keys_str_mv	AT sivadasanpillaiharikrishnan dietthegutmicrobiomeandheartfailure
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Diet, the Gut Microbiome and Heart Failure

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