Sfrp5 identifies murine cardiac progenitors for all myocardial structures except for the right ventricle

It is unclear which progenitors define different regions of the heart. Here, the authors find Secreted frizzled-related protein 5 is expressed in murine progenitor cells for the outflow tract, first heart field, and sinus venosus, but not the right ventricle, and Wnt inhibition prevents progenitor p...

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Autores principales: Masayuki Fujii, Akane Sakaguchi, Ryo Kamata, Masataka Nagao, Yutaka Kikuchi, Silvia M. Evans, Masao Yoshizumi, Akihiko Shimono, Yumiko Saga, Hiroki Kokubo
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/10ea881258354959abbab40934287ec8
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Sumario:It is unclear which progenitors define different regions of the heart. Here, the authors find Secreted frizzled-related protein 5 is expressed in murine progenitor cells for the outflow tract, first heart field, and sinus venosus, but not the right ventricle, and Wnt inhibition prevents progenitor proliferation.