Phenotypes on demand via switchable target protein degradation in multicellular organisms

Switching target protein accumulation and activity by portable conditional degrons is potentially useful for both basic research and bioengineering. Here the authors present a versatile system to tune protein levels in live animals and plants using a temperature-sensitive N-end rule degradation sign...

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Autores principales:	Frederik Faden, Thomas Ramezani, Stefan Mielke, Isabel Almudi, Knud Nairz, Marceli S. Froehlich, Jörg Höckendorff, Wolfgang Brandt, Wolfgang Hoehenwarter, R. Jürgen Dohmen, Arp Schnittger, Nico Dissmeyer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/10f345e55eab42f3a056bfd9d5b7d2a2
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spelling	oai:doaj.org-article:10f345e55eab42f3a056bfd9d5b7d2a22021-12-02T14:38:57ZPhenotypes on demand via switchable target protein degradation in multicellular organisms10.1038/ncomms122022041-1723https://doaj.org/article/10f345e55eab42f3a056bfd9d5b7d2a22016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12202https://doaj.org/toc/2041-1723Switching target protein accumulation and activity by portable conditional degrons is potentially useful for both basic research and bioengineering. Here the authors present a versatile system to tune protein levels in live animals and plants using a temperature-sensitive N-end rule degradation signal.Frederik FadenThomas RamezaniStefan MielkeIsabel AlmudiKnud NairzMarceli S. FroehlichJörg HöckendorffWolfgang BrandtWolfgang HoehenwarterR. Jürgen DohmenArp SchnittgerNico DissmeyerNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Frederik Faden Thomas Ramezani Stefan Mielke Isabel Almudi Knud Nairz Marceli S. Froehlich Jörg Höckendorff Wolfgang Brandt Wolfgang Hoehenwarter R. Jürgen Dohmen Arp Schnittger Nico Dissmeyer Phenotypes on demand via switchable target protein degradation in multicellular organisms
description	Switching target protein accumulation and activity by portable conditional degrons is potentially useful for both basic research and bioengineering. Here the authors present a versatile system to tune protein levels in live animals and plants using a temperature-sensitive N-end rule degradation signal.
format	article
author	Frederik Faden Thomas Ramezani Stefan Mielke Isabel Almudi Knud Nairz Marceli S. Froehlich Jörg Höckendorff Wolfgang Brandt Wolfgang Hoehenwarter R. Jürgen Dohmen Arp Schnittger Nico Dissmeyer
author_facet	Frederik Faden Thomas Ramezani Stefan Mielke Isabel Almudi Knud Nairz Marceli S. Froehlich Jörg Höckendorff Wolfgang Brandt Wolfgang Hoehenwarter R. Jürgen Dohmen Arp Schnittger Nico Dissmeyer
author_sort	Frederik Faden
title	Phenotypes on demand via switchable target protein degradation in multicellular organisms
title_short	Phenotypes on demand via switchable target protein degradation in multicellular organisms
title_full	Phenotypes on demand via switchable target protein degradation in multicellular organisms
title_fullStr	Phenotypes on demand via switchable target protein degradation in multicellular organisms
title_full_unstemmed	Phenotypes on demand via switchable target protein degradation in multicellular organisms
title_sort	phenotypes on demand via switchable target protein degradation in multicellular organisms
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/10f345e55eab42f3a056bfd9d5b7d2a2
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Phenotypes on demand via switchable target protein degradation in multicellular organisms

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