Managing Severe Dysgeusia and Dysosmia in Lung Cancer Patients: A Systematic Scoping Review

IntroductionLung cancer (LC) is highly prevalent worldwide, with elevated mortality. In this population, taste and smell alterations (TSAs) are frequent but overlooked symptoms. The absence of effective therapeutic strategies and evidence-based guidelines constrain TSAs’ early recognition, preventio...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Ana Sofia Spencer, David da Silva Dias, Manuel Luís Capelas, Francisco Pimentel, Teresa Santos, Pedro Miguel Neves, Antti Mäkitie, Paula Ravasco
Formato: article
Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://doaj.org/article/10f3865c4d054232926631b049fa8e49
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:10f3865c4d054232926631b049fa8e49
record_format dspace
spelling oai:doaj.org-article:10f3865c4d054232926631b049fa8e492021-11-22T07:22:26ZManaging Severe Dysgeusia and Dysosmia in Lung Cancer Patients: A Systematic Scoping Review2234-943X10.3389/fonc.2021.774081https://doaj.org/article/10f3865c4d054232926631b049fa8e492021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.774081/fullhttps://doaj.org/toc/2234-943XIntroductionLung cancer (LC) is highly prevalent worldwide, with elevated mortality. In this population, taste and smell alterations (TSAs) are frequent but overlooked symptoms. The absence of effective therapeutic strategies and evidence-based guidelines constrain TSAs’ early recognition, prevention and treatment (Tx), promoting cancer-related malnutrition and jeopardizing survival outcomes and quality of life.ObjectivesTo systematically review the literature on TSAs in LC patients, understand the physiopathology, identify potential preventive and Tx strategies and to further encourage research in this area.MethodsLiterature search on English language articles indexed to PubMed, CINALH, SCOPUS and Web of Science using MeSH terms “Lung neoplasms”,”Dysgeusia”, “Olfaction Disorders”, “Carcinoma, Small Cell”,”Carcinoma, Non- Small-Cell Lung “Adenocarcinoma of Lung”,”Carcinoma, Large Cell”, and non-MeSH terms “Parageusia”, “Altered Taste”, “Smell Disorder”, “Paraosmia”, “Dysosmia”,”Lung Cancer” and “Oat Cell Carcinoma”.ResultsThirty-four articles were reviewed. TSAs may follow the diagnosis of LC or develop during cancer Tx. The estimated prevalence of self-reported dysgeusia is 35-38% in treatment-naïve LC patients, and 35-69% in those undergoing Tx, based on studies involving LC patients only.One prospective pilot trial and 1 RCT demonstrated a clinically significant benefit in combining flavor enhancement, smell and taste training and individualized nutritional counselling; a systematic review, 1 RCT and 1 retrospective study favored using intravenous or oral zinc-based solutions (150mg 2-3 times a day) for the prevention and Tx of chemotherapy (CT) and radiotherapy (RT) -induced mucositis and subsequent dysgeusia.ConclusionsThis is the first review on dysgeusia and dysosmia in LC patients to our knowledge. We propose combining taste and smell training, personalized dietary counselling and flavor enhancement with oral zinc-based solutions (150mg, 2-3 times a day) during CT and/or RT in this population, in order to prevent and help ameliorate Tx-induced dysgeusia and mucositis. However due to study heterogeneity, the results should be interpreted with caution. Developing standardized TSA measurement tools and performing prospective randomized controlled trials to evaluate their effect are warranted.Ana Sofia SpencerDavid da Silva DiasDavid da Silva DiasDavid da Silva DiasManuel Luís CapelasManuel Luís CapelasFrancisco PimentelTeresa SantosTeresa SantosTeresa SantosTeresa SantosPedro Miguel NevesPedro Miguel NevesAntti MäkitieAntti MäkitieAntti MäkitiePaula RavascoPaula RavascoPaula RavascoPaula RavascoFrontiers Media S.A.articledysgeusiadysosmiataste and smell alterations (TSAs)lung cancerdietary counsellingzincNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution DOAJ
collection DOAJ
language EN
topic dysgeusia
dysosmia
taste and smell alterations (TSAs)
lung cancer
dietary counselling
zinc
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
spellingShingle dysgeusia
dysosmia
taste and smell alterations (TSAs)
lung cancer
dietary counselling
zinc
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Ana Sofia Spencer
David da Silva Dias
David da Silva Dias
David da Silva Dias
Manuel Luís Capelas
Manuel Luís Capelas
Francisco Pimentel
Teresa Santos
Teresa Santos
Teresa Santos
Teresa Santos
Pedro Miguel Neves
Pedro Miguel Neves
Antti Mäkitie
Antti Mäkitie
Antti Mäkitie
Paula Ravasco
Paula Ravasco
Paula Ravasco
Paula Ravasco
Managing Severe Dysgeusia and Dysosmia in Lung Cancer Patients: A Systematic Scoping Review
description IntroductionLung cancer (LC) is highly prevalent worldwide, with elevated mortality. In this population, taste and smell alterations (TSAs) are frequent but overlooked symptoms. The absence of effective therapeutic strategies and evidence-based guidelines constrain TSAs’ early recognition, prevention and treatment (Tx), promoting cancer-related malnutrition and jeopardizing survival outcomes and quality of life.ObjectivesTo systematically review the literature on TSAs in LC patients, understand the physiopathology, identify potential preventive and Tx strategies and to further encourage research in this area.MethodsLiterature search on English language articles indexed to PubMed, CINALH, SCOPUS and Web of Science using MeSH terms “Lung neoplasms”,”Dysgeusia”, “Olfaction Disorders”, “Carcinoma, Small Cell”,”Carcinoma, Non- Small-Cell Lung “Adenocarcinoma of Lung”,”Carcinoma, Large Cell”, and non-MeSH terms “Parageusia”, “Altered Taste”, “Smell Disorder”, “Paraosmia”, “Dysosmia”,”Lung Cancer” and “Oat Cell Carcinoma”.ResultsThirty-four articles were reviewed. TSAs may follow the diagnosis of LC or develop during cancer Tx. The estimated prevalence of self-reported dysgeusia is 35-38% in treatment-naïve LC patients, and 35-69% in those undergoing Tx, based on studies involving LC patients only.One prospective pilot trial and 1 RCT demonstrated a clinically significant benefit in combining flavor enhancement, smell and taste training and individualized nutritional counselling; a systematic review, 1 RCT and 1 retrospective study favored using intravenous or oral zinc-based solutions (150mg 2-3 times a day) for the prevention and Tx of chemotherapy (CT) and radiotherapy (RT) -induced mucositis and subsequent dysgeusia.ConclusionsThis is the first review on dysgeusia and dysosmia in LC patients to our knowledge. We propose combining taste and smell training, personalized dietary counselling and flavor enhancement with oral zinc-based solutions (150mg, 2-3 times a day) during CT and/or RT in this population, in order to prevent and help ameliorate Tx-induced dysgeusia and mucositis. However due to study heterogeneity, the results should be interpreted with caution. Developing standardized TSA measurement tools and performing prospective randomized controlled trials to evaluate their effect are warranted.
format article
author Ana Sofia Spencer
David da Silva Dias
David da Silva Dias
David da Silva Dias
Manuel Luís Capelas
Manuel Luís Capelas
Francisco Pimentel
Teresa Santos
Teresa Santos
Teresa Santos
Teresa Santos
Pedro Miguel Neves
Pedro Miguel Neves
Antti Mäkitie
Antti Mäkitie
Antti Mäkitie
Paula Ravasco
Paula Ravasco
Paula Ravasco
Paula Ravasco
author_facet Ana Sofia Spencer
David da Silva Dias
David da Silva Dias
David da Silva Dias
Manuel Luís Capelas
Manuel Luís Capelas
Francisco Pimentel
Teresa Santos
Teresa Santos
Teresa Santos
Teresa Santos
Pedro Miguel Neves
Pedro Miguel Neves
Antti Mäkitie
Antti Mäkitie
Antti Mäkitie
Paula Ravasco
Paula Ravasco
Paula Ravasco
Paula Ravasco
author_sort Ana Sofia Spencer
title Managing Severe Dysgeusia and Dysosmia in Lung Cancer Patients: A Systematic Scoping Review
title_short Managing Severe Dysgeusia and Dysosmia in Lung Cancer Patients: A Systematic Scoping Review
title_full Managing Severe Dysgeusia and Dysosmia in Lung Cancer Patients: A Systematic Scoping Review
title_fullStr Managing Severe Dysgeusia and Dysosmia in Lung Cancer Patients: A Systematic Scoping Review
title_full_unstemmed Managing Severe Dysgeusia and Dysosmia in Lung Cancer Patients: A Systematic Scoping Review
title_sort managing severe dysgeusia and dysosmia in lung cancer patients: a systematic scoping review
publisher Frontiers Media S.A.
publishDate 2021
url https://doaj.org/article/10f3865c4d054232926631b049fa8e49
work_keys_str_mv AT anasofiaspencer managingseveredysgeusiaanddysosmiainlungcancerpatientsasystematicscopingreview
AT daviddasilvadias managingseveredysgeusiaanddysosmiainlungcancerpatientsasystematicscopingreview
AT daviddasilvadias managingseveredysgeusiaanddysosmiainlungcancerpatientsasystematicscopingreview
AT daviddasilvadias managingseveredysgeusiaanddysosmiainlungcancerpatientsasystematicscopingreview
AT manuelluiscapelas managingseveredysgeusiaanddysosmiainlungcancerpatientsasystematicscopingreview
AT manuelluiscapelas managingseveredysgeusiaanddysosmiainlungcancerpatientsasystematicscopingreview
AT franciscopimentel managingseveredysgeusiaanddysosmiainlungcancerpatientsasystematicscopingreview
AT teresasantos managingseveredysgeusiaanddysosmiainlungcancerpatientsasystematicscopingreview
AT teresasantos managingseveredysgeusiaanddysosmiainlungcancerpatientsasystematicscopingreview
AT teresasantos managingseveredysgeusiaanddysosmiainlungcancerpatientsasystematicscopingreview
AT teresasantos managingseveredysgeusiaanddysosmiainlungcancerpatientsasystematicscopingreview
AT pedromiguelneves managingseveredysgeusiaanddysosmiainlungcancerpatientsasystematicscopingreview
AT pedromiguelneves managingseveredysgeusiaanddysosmiainlungcancerpatientsasystematicscopingreview
AT anttimakitie managingseveredysgeusiaanddysosmiainlungcancerpatientsasystematicscopingreview
AT anttimakitie managingseveredysgeusiaanddysosmiainlungcancerpatientsasystematicscopingreview
AT anttimakitie managingseveredysgeusiaanddysosmiainlungcancerpatientsasystematicscopingreview
AT paularavasco managingseveredysgeusiaanddysosmiainlungcancerpatientsasystematicscopingreview
AT paularavasco managingseveredysgeusiaanddysosmiainlungcancerpatientsasystematicscopingreview
AT paularavasco managingseveredysgeusiaanddysosmiainlungcancerpatientsasystematicscopingreview
AT paularavasco managingseveredysgeusiaanddysosmiainlungcancerpatientsasystematicscopingreview
_version_ 1718417838808498176