Ischemic and Bleeding Outcomes According to the Academic Research Consortium High Bleeding Risk Criteria in All Comers Treated by Percutaneous Coronary Interventions

Background: The Academic Research Consortium have identified a set of major and minor risk factors in order to standardize the definition of a High Bleeding Risk (ACR-HBR).Aims: The aim of this study is to stratify the bleeding risk in patients included in the Cardio-Fribourg registry, according to...

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Autores principales:	Daphné Doomun, Ianis Doomun, Sara Schukraft, Diego Arroyo, Selma Cook, Tibor Huwyler, Peter Wenaweser, Jean-Christophe Stauffer, Jean-Jacques Goy, Mario Togni, Serban Puricel, Stéphane Cook
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	high bleeding risk ACR-HBR criteria percutaneous coronary intervention antithrombotic therapy major criteria minor criteria Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/10f55881851a4a3ab385aca9dee0c0e5
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spelling	oai:doaj.org-article:10f55881851a4a3ab385aca9dee0c0e52021-12-02T08:36:32ZIschemic and Bleeding Outcomes According to the Academic Research Consortium High Bleeding Risk Criteria in All Comers Treated by Percutaneous Coronary Interventions2297-055X10.3389/fcvm.2021.620354https://doaj.org/article/10f55881851a4a3ab385aca9dee0c0e52021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcvm.2021.620354/fullhttps://doaj.org/toc/2297-055XBackground: The Academic Research Consortium have identified a set of major and minor risk factors in order to standardize the definition of a High Bleeding Risk (ACR-HBR).Aims: The aim of this study is to stratify the bleeding risk in patients included in the Cardio-Fribourg registry, according to the Academic Research Consortium for High Bleeding Risk (ACR-HBR) definition, and to report ischemic and hemorrhagic events at 2-year of clinical follow-up.Methods: Between 2015 and 2017, consecutive patients undergoing percutaneous coronary intervention were prospectively included in the Cardio-Fribourg registry. Patients were considered high (HBR) or low (LBR) bleeding risk depending on the ARC-HBR definition. Primary endpoints were hierarchical major bleeding events as defined by the Bleeding Academic Research Consortium (BARC) grade 3–5, and ARC patient-oriented major adverse cardiac events (POCE) at 2-year follow-up.Results: Follow-up was complete in 1,080 patients. There were 354 patients in the HBR group (32.7%) and 726 patients in the low-bleeding risk (LBR) group (67.2%). At 2-year follow-up, cumulative BARC 3–5 bleedings were higher in HBR (10.5%) compared to LBR patients (1.5%, p < 0.01) and the impact of HBR risk factors was incremental. At 2-year follow-up, POCE were more frequent in HBR (27.4%) compared to LBR group (18.2%, <0.01). Overall mortality was higher in HBR (14.0%) vs. LBR (2.9%, p < 0.01).Conclusions: ARC-HBR criteria appropriately identified a population at a higher risk of bleeding after percutaneous coronary intervention. An increased risk of bleeding is also associated with an increased risk of ischemic events at 2-year follow-up.Daphné DoomunIanis DoomunSara SchukraftDiego ArroyoSelma CookTibor HuwylerPeter WenaweserJean-Christophe StaufferJean-Jacques GoyMario TogniSerban PuricelStéphane CookFrontiers Media S.A.articlehigh bleeding riskACR-HBR criteriapercutaneous coronary interventionantithrombotic therapymajor criteriaminor criteriaDiseases of the circulatory (Cardiovascular) systemRC666-701ENFrontiers in Cardiovascular Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	high bleeding risk ACR-HBR criteria percutaneous coronary intervention antithrombotic therapy major criteria minor criteria Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	high bleeding risk ACR-HBR criteria percutaneous coronary intervention antithrombotic therapy major criteria minor criteria Diseases of the circulatory (Cardiovascular) system RC666-701 Daphné Doomun Ianis Doomun Sara Schukraft Diego Arroyo Selma Cook Tibor Huwyler Peter Wenaweser Jean-Christophe Stauffer Jean-Jacques Goy Mario Togni Serban Puricel Stéphane Cook Ischemic and Bleeding Outcomes According to the Academic Research Consortium High Bleeding Risk Criteria in All Comers Treated by Percutaneous Coronary Interventions
description	Background: The Academic Research Consortium have identified a set of major and minor risk factors in order to standardize the definition of a High Bleeding Risk (ACR-HBR).Aims: The aim of this study is to stratify the bleeding risk in patients included in the Cardio-Fribourg registry, according to the Academic Research Consortium for High Bleeding Risk (ACR-HBR) definition, and to report ischemic and hemorrhagic events at 2-year of clinical follow-up.Methods: Between 2015 and 2017, consecutive patients undergoing percutaneous coronary intervention were prospectively included in the Cardio-Fribourg registry. Patients were considered high (HBR) or low (LBR) bleeding risk depending on the ARC-HBR definition. Primary endpoints were hierarchical major bleeding events as defined by the Bleeding Academic Research Consortium (BARC) grade 3–5, and ARC patient-oriented major adverse cardiac events (POCE) at 2-year follow-up.Results: Follow-up was complete in 1,080 patients. There were 354 patients in the HBR group (32.7%) and 726 patients in the low-bleeding risk (LBR) group (67.2%). At 2-year follow-up, cumulative BARC 3–5 bleedings were higher in HBR (10.5%) compared to LBR patients (1.5%, p < 0.01) and the impact of HBR risk factors was incremental. At 2-year follow-up, POCE were more frequent in HBR (27.4%) compared to LBR group (18.2%, <0.01). Overall mortality was higher in HBR (14.0%) vs. LBR (2.9%, p < 0.01).Conclusions: ARC-HBR criteria appropriately identified a population at a higher risk of bleeding after percutaneous coronary intervention. An increased risk of bleeding is also associated with an increased risk of ischemic events at 2-year follow-up.
format	article
author	Daphné Doomun Ianis Doomun Sara Schukraft Diego Arroyo Selma Cook Tibor Huwyler Peter Wenaweser Jean-Christophe Stauffer Jean-Jacques Goy Mario Togni Serban Puricel Stéphane Cook
author_facet	Daphné Doomun Ianis Doomun Sara Schukraft Diego Arroyo Selma Cook Tibor Huwyler Peter Wenaweser Jean-Christophe Stauffer Jean-Jacques Goy Mario Togni Serban Puricel Stéphane Cook
author_sort	Daphné Doomun
title	Ischemic and Bleeding Outcomes According to the Academic Research Consortium High Bleeding Risk Criteria in All Comers Treated by Percutaneous Coronary Interventions
title_short	Ischemic and Bleeding Outcomes According to the Academic Research Consortium High Bleeding Risk Criteria in All Comers Treated by Percutaneous Coronary Interventions
title_full	Ischemic and Bleeding Outcomes According to the Academic Research Consortium High Bleeding Risk Criteria in All Comers Treated by Percutaneous Coronary Interventions
title_fullStr	Ischemic and Bleeding Outcomes According to the Academic Research Consortium High Bleeding Risk Criteria in All Comers Treated by Percutaneous Coronary Interventions
title_full_unstemmed	Ischemic and Bleeding Outcomes According to the Academic Research Consortium High Bleeding Risk Criteria in All Comers Treated by Percutaneous Coronary Interventions
title_sort	ischemic and bleeding outcomes according to the academic research consortium high bleeding risk criteria in all comers treated by percutaneous coronary interventions
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/10f55881851a4a3ab385aca9dee0c0e5
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Ischemic and Bleeding Outcomes According to the Academic Research Consortium High Bleeding Risk Criteria in All Comers Treated by Percutaneous Coronary Interventions

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