ZFYVE21 is a complement-induced Rab5 effector that activates non-canonical NF-κB via phosphoinosotide remodeling of endosomes

ZFYVE21 is a complement-induced Rab5 effector that activates non-canonical NF-κB via phosphoinosotide remodeling of endosomes

Complement activation contributes to vascular inflammation in the contexts of allograft rejection and connective tissue disease. Here Fang et al. identify ZFYVE21 as a novel effector of Rab5 and find it regulates pro-inflammatory NF-κB signaling in endothelial cells in response to complement activat...

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Detalles Bibliográficos
Autores principales: Caodi Fang, Thomas D. Manes, Lufang Liu, Kevin Liu, Lingfeng Qin, Guangxin Li, Zuzana Tobiasova, Nancy C. Kirkiles-Smith, Manal Patel, Jonathan Merola, Whitney Fu, Rebecca Liu, Catherine Xie, Gregory T. Tietjen, Peter A. Nigrovic, George Tellides, Jordan S. Pober, Dan Jane-wit
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/10fc1ad54b2945a89fd483e641d510ad
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Sumario:Complement activation contributes to vascular inflammation in the contexts of allograft rejection and connective tissue disease. Here Fang et al. identify ZFYVE21 as a novel effector of Rab5 and find it regulates pro-inflammatory NF-κB signaling in endothelial cells in response to complement activation.

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