ZFYVE21 is a complement-induced Rab5 effector that activates non-canonical NF-κB via phosphoinosotide remodeling of endosomes
Complement activation contributes to vascular inflammation in the contexts of allograft rejection and connective tissue disease. Here Fang et al. identify ZFYVE21 as a novel effector of Rab5 and find it regulates pro-inflammatory NF-κB signaling in endothelial cells in response to complement activat...
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Nature Portfolio
2019
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oai:doaj.org-article:10fc1ad54b2945a89fd483e641d510ad2021-12-02T14:40:02ZZFYVE21 is a complement-induced Rab5 effector that activates non-canonical NF-κB via phosphoinosotide remodeling of endosomes10.1038/s41467-019-10041-22041-1723https://doaj.org/article/10fc1ad54b2945a89fd483e641d510ad2019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10041-2https://doaj.org/toc/2041-1723Complement activation contributes to vascular inflammation in the contexts of allograft rejection and connective tissue disease. Here Fang et al. identify ZFYVE21 as a novel effector of Rab5 and find it regulates pro-inflammatory NF-κB signaling in endothelial cells in response to complement activation.Caodi FangThomas D. ManesLufang LiuKevin LiuLingfeng QinGuangxin LiZuzana TobiasovaNancy C. Kirkiles-SmithManal PatelJonathan MerolaWhitney FuRebecca LiuCatherine XieGregory T. TietjenPeter A. NigrovicGeorge TellidesJordan S. PoberDan Jane-witNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019) |
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DOAJ |
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Science Q Caodi Fang Thomas D. Manes Lufang Liu Kevin Liu Lingfeng Qin Guangxin Li Zuzana Tobiasova Nancy C. Kirkiles-Smith Manal Patel Jonathan Merola Whitney Fu Rebecca Liu Catherine Xie Gregory T. Tietjen Peter A. Nigrovic George Tellides Jordan S. Pober Dan Jane-wit ZFYVE21 is a complement-induced Rab5 effector that activates non-canonical NF-κB via phosphoinosotide remodeling of endosomes |
description |
Complement activation contributes to vascular inflammation in the contexts of allograft rejection and connective tissue disease. Here Fang et al. identify ZFYVE21 as a novel effector of Rab5 and find it regulates pro-inflammatory NF-κB signaling in endothelial cells in response to complement activation. |
format |
article |
author |
Caodi Fang Thomas D. Manes Lufang Liu Kevin Liu Lingfeng Qin Guangxin Li Zuzana Tobiasova Nancy C. Kirkiles-Smith Manal Patel Jonathan Merola Whitney Fu Rebecca Liu Catherine Xie Gregory T. Tietjen Peter A. Nigrovic George Tellides Jordan S. Pober Dan Jane-wit |
author_facet |
Caodi Fang Thomas D. Manes Lufang Liu Kevin Liu Lingfeng Qin Guangxin Li Zuzana Tobiasova Nancy C. Kirkiles-Smith Manal Patel Jonathan Merola Whitney Fu Rebecca Liu Catherine Xie Gregory T. Tietjen Peter A. Nigrovic George Tellides Jordan S. Pober Dan Jane-wit |
author_sort |
Caodi Fang |
title |
ZFYVE21 is a complement-induced Rab5 effector that activates non-canonical NF-κB via phosphoinosotide remodeling of endosomes |
title_short |
ZFYVE21 is a complement-induced Rab5 effector that activates non-canonical NF-κB via phosphoinosotide remodeling of endosomes |
title_full |
ZFYVE21 is a complement-induced Rab5 effector that activates non-canonical NF-κB via phosphoinosotide remodeling of endosomes |
title_fullStr |
ZFYVE21 is a complement-induced Rab5 effector that activates non-canonical NF-κB via phosphoinosotide remodeling of endosomes |
title_full_unstemmed |
ZFYVE21 is a complement-induced Rab5 effector that activates non-canonical NF-κB via phosphoinosotide remodeling of endosomes |
title_sort |
zfyve21 is a complement-induced rab5 effector that activates non-canonical nf-κb via phosphoinosotide remodeling of endosomes |
publisher |
Nature Portfolio |
publishDate |
2019 |
url |
https://doaj.org/article/10fc1ad54b2945a89fd483e641d510ad |
work_keys_str_mv |
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