ZFYVE21 is a complement-induced Rab5 effector that activates non-canonical NF-κB via phosphoinosotide remodeling of endosomes

Complement activation contributes to vascular inflammation in the contexts of allograft rejection and connective tissue disease. Here Fang et al. identify ZFYVE21 as a novel effector of Rab5 and find it regulates pro-inflammatory NF-κB signaling in endothelial cells in response to complement activat...

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Autores principales:	Caodi Fang, Thomas D. Manes, Lufang Liu, Kevin Liu, Lingfeng Qin, Guangxin Li, Zuzana Tobiasova, Nancy C. Kirkiles-Smith, Manal Patel, Jonathan Merola, Whitney Fu, Rebecca Liu, Catherine Xie, Gregory T. Tietjen, Peter A. Nigrovic, George Tellides, Jordan S. Pober, Dan Jane-wit
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/10fc1ad54b2945a89fd483e641d510ad
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spelling	oai:doaj.org-article:10fc1ad54b2945a89fd483e641d510ad2021-12-02T14:40:02ZZFYVE21 is a complement-induced Rab5 effector that activates non-canonical NF-κB via phosphoinosotide remodeling of endosomes10.1038/s41467-019-10041-22041-1723https://doaj.org/article/10fc1ad54b2945a89fd483e641d510ad2019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10041-2https://doaj.org/toc/2041-1723Complement activation contributes to vascular inflammation in the contexts of allograft rejection and connective tissue disease. Here Fang et al. identify ZFYVE21 as a novel effector of Rab5 and find it regulates pro-inflammatory NF-κB signaling in endothelial cells in response to complement activation.Caodi FangThomas D. ManesLufang LiuKevin LiuLingfeng QinGuangxin LiZuzana TobiasovaNancy C. Kirkiles-SmithManal PatelJonathan MerolaWhitney FuRebecca LiuCatherine XieGregory T. TietjenPeter A. NigrovicGeorge TellidesJordan S. PoberDan Jane-witNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Caodi Fang Thomas D. Manes Lufang Liu Kevin Liu Lingfeng Qin Guangxin Li Zuzana Tobiasova Nancy C. Kirkiles-Smith Manal Patel Jonathan Merola Whitney Fu Rebecca Liu Catherine Xie Gregory T. Tietjen Peter A. Nigrovic George Tellides Jordan S. Pober Dan Jane-wit ZFYVE21 is a complement-induced Rab5 effector that activates non-canonical NF-κB via phosphoinosotide remodeling of endosomes
description	Complement activation contributes to vascular inflammation in the contexts of allograft rejection and connective tissue disease. Here Fang et al. identify ZFYVE21 as a novel effector of Rab5 and find it regulates pro-inflammatory NF-κB signaling in endothelial cells in response to complement activation.
format	article
author	Caodi Fang Thomas D. Manes Lufang Liu Kevin Liu Lingfeng Qin Guangxin Li Zuzana Tobiasova Nancy C. Kirkiles-Smith Manal Patel Jonathan Merola Whitney Fu Rebecca Liu Catherine Xie Gregory T. Tietjen Peter A. Nigrovic George Tellides Jordan S. Pober Dan Jane-wit
author_facet	Caodi Fang Thomas D. Manes Lufang Liu Kevin Liu Lingfeng Qin Guangxin Li Zuzana Tobiasova Nancy C. Kirkiles-Smith Manal Patel Jonathan Merola Whitney Fu Rebecca Liu Catherine Xie Gregory T. Tietjen Peter A. Nigrovic George Tellides Jordan S. Pober Dan Jane-wit
author_sort	Caodi Fang
title	ZFYVE21 is a complement-induced Rab5 effector that activates non-canonical NF-κB via phosphoinosotide remodeling of endosomes
title_short	ZFYVE21 is a complement-induced Rab5 effector that activates non-canonical NF-κB via phosphoinosotide remodeling of endosomes
title_full	ZFYVE21 is a complement-induced Rab5 effector that activates non-canonical NF-κB via phosphoinosotide remodeling of endosomes
title_fullStr	ZFYVE21 is a complement-induced Rab5 effector that activates non-canonical NF-κB via phosphoinosotide remodeling of endosomes
title_full_unstemmed	ZFYVE21 is a complement-induced Rab5 effector that activates non-canonical NF-κB via phosphoinosotide remodeling of endosomes
title_sort	zfyve21 is a complement-induced rab5 effector that activates non-canonical nf-κb via phosphoinosotide remodeling of endosomes
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/10fc1ad54b2945a89fd483e641d510ad
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ZFYVE21 is a complement-induced Rab5 effector that activates non-canonical NF-κB via phosphoinosotide remodeling of endosomes

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