Empirical mean-noise fitness landscapes reveal the fitness impact of gene expression noise

Quantifying the effects of noise in gene expression is difficult since noise and mean expression are coupled. Here the authors determine fitness landscapes in mean-noise expression space to uncouple these two parameters and show that changes in noise and mean expression are similarly detrimental to...

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Autores principales:	Jörn M. Schmiedel, Lucas B. Carey, Ben Lehner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/10feb400f6b84630a3dac2896ceecceb
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id	oai:doaj.org-article:10feb400f6b84630a3dac2896ceecceb
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spelling	oai:doaj.org-article:10feb400f6b84630a3dac2896ceecceb2021-12-02T15:35:11ZEmpirical mean-noise fitness landscapes reveal the fitness impact of gene expression noise10.1038/s41467-019-11116-w2041-1723https://doaj.org/article/10feb400f6b84630a3dac2896ceecceb2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11116-whttps://doaj.org/toc/2041-1723Quantifying the effects of noise in gene expression is difficult since noise and mean expression are coupled. Here the authors determine fitness landscapes in mean-noise expression space to uncouple these two parameters and show that changes in noise and mean expression are similarly detrimental to fitness.Jörn M. SchmiedelLucas B. CareyBen LehnerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jörn M. Schmiedel Lucas B. Carey Ben Lehner Empirical mean-noise fitness landscapes reveal the fitness impact of gene expression noise
description	Quantifying the effects of noise in gene expression is difficult since noise and mean expression are coupled. Here the authors determine fitness landscapes in mean-noise expression space to uncouple these two parameters and show that changes in noise and mean expression are similarly detrimental to fitness.
format	article
author	Jörn M. Schmiedel Lucas B. Carey Ben Lehner
author_facet	Jörn M. Schmiedel Lucas B. Carey Ben Lehner
author_sort	Jörn M. Schmiedel
title	Empirical mean-noise fitness landscapes reveal the fitness impact of gene expression noise
title_short	Empirical mean-noise fitness landscapes reveal the fitness impact of gene expression noise
title_full	Empirical mean-noise fitness landscapes reveal the fitness impact of gene expression noise
title_fullStr	Empirical mean-noise fitness landscapes reveal the fitness impact of gene expression noise
title_full_unstemmed	Empirical mean-noise fitness landscapes reveal the fitness impact of gene expression noise
title_sort	empirical mean-noise fitness landscapes reveal the fitness impact of gene expression noise
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/10feb400f6b84630a3dac2896ceecceb
work_keys_str_mv	AT jornmschmiedel empiricalmeannoisefitnesslandscapesrevealthefitnessimpactofgeneexpressionnoise AT lucasbcarey empiricalmeannoisefitnesslandscapesrevealthefitnessimpactofgeneexpressionnoise AT benlehner empiricalmeannoisefitnesslandscapesrevealthefitnessimpactofgeneexpressionnoise
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Empirical mean-noise fitness landscapes reveal the fitness impact of gene expression noise

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