Comorbidity of Fibromyalgia in Primary Knee Osteoarthritis: Potential Impact on Functional Status and Quality of Life

Marwa Yahia Mahgoub,1 Basant Mohamed Elnady,1 Haytham Sayed Abdelkader,2 Raghdaa Abdelkhaleq Abdelhalem,2 Waleed Ahmed Hassan1 1Rheumatology, Rehabilitation and Physical Medicine Department, Benha University, Benha, Egypt; 2Neuropsychiatry Department, Benha University, Benha, EgyptCorrespondence: Ma...

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Autores principales:	Mahgoub MY, Elnady BM, Abdelkader HS, Abdelhalem RA, Hassan WA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	knee osteoarthritis fibromyalgia central sensitization osteoarthritis pain. Diseases of the musculoskeletal system RC925-935
Acceso en línea:	https://doaj.org/article/1101f92dd26143798ed2c652e894d3ab
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spelling	oai:doaj.org-article:1101f92dd26143798ed2c652e894d3ab2021-12-02T10:38:57ZComorbidity of Fibromyalgia in Primary Knee Osteoarthritis: Potential Impact on Functional Status and Quality of Life1179-156Xhttps://doaj.org/article/1101f92dd26143798ed2c652e894d3ab2020-05-01T00:00:00Zhttps://www.dovepress.com/comorbidity-of-fibromyalgia-in-primary-knee-osteoarthritis-potential-i-peer-reviewed-article-OARRRhttps://doaj.org/toc/1179-156XMarwa Yahia Mahgoub,1 Basant Mohamed Elnady,1 Haytham Sayed Abdelkader,2 Raghdaa Abdelkhaleq Abdelhalem,2 Waleed Ahmed Hassan1 1Rheumatology, Rehabilitation and Physical Medicine Department, Benha University, Benha, Egypt; 2Neuropsychiatry Department, Benha University, Benha, EgyptCorrespondence: Marwa Yahia Mahgoub Email marwa.yahia@fmed.bu.edu.egBackground: Knee osteoarthritis (OA) is a painful condition with peripheral and central pain transmission. Fibromyalgia (FM) is the role model of central sensitization of pain perception.Aim: To assess the frequency of FM in knee OA patients and evaluate the impact of FM on mental health and the quality of life in knee OA patients.Patients and Methods: A total of 121 female patients were recruited and divided into 3 groups: group I of 59 patients with knee OA only, group II of 32 patients with knee OA and FM, and group III of 30 FM patients. Patients underwent history taking, examination, investigations, and radiological evaluation of both knees. The assessment of visual analog scale (VAS), Pittsburgh Sleep Quality Index (PSQI), Pain Anxiety Symptom Scale Short Form 20 (PASS20), Beck Depression Inventory (BDI-II), and PCASEE questionnaire were done for all patients. Lequesne index of knee OA and radiological Kellgren and Lawrence score severity were done for all OA patients. Fibromyalgia Impact Questionnaire (FIQ) was assessed for all FM patients.Results: FM was diagnosed in 35.5% of knee OA patients. Group II patients had higher VAS, PASS-20, PSQI, and lower quality of life than either groups I and III, elevated Lequesne index score than group I, significant correlation between VAS and BMI (p=0.002), Lequesne index score (p< 0.001), PASS20 (p=0.006), BDI-II score (p=0.002), and FIQ (P< 0.001), and a negative correlation was found between VAS and physical (p< 0.001), anxiety (p=0.046), and social (p=0.026) QoL parameters. Univariable regression analysis showed a higher age, VAS, PSQI, PASS20, and FIQ were associated with lower QoL in group II. A higher PASS20 was the only predictor of lower QoL in multivariable analysis.Conclusion: Fibromyalgia coexists frequently in knee OA patients and has implications on their mental health, functional activity, and quality of life.Keywords: knee osteoarthritis, fibromyalgia, central sensitization, osteoarthritis painMahgoub MYElnady BMAbdelkader HSAbdelhalem RAHassan WADove Medical Pressarticleknee osteoarthritisfibromyalgiacentral sensitizationosteoarthritis pain.Diseases of the musculoskeletal systemRC925-935ENOpen Access Rheumatology: Research and Reviews, Vol Volume 12, Pp 55-63 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	knee osteoarthritis fibromyalgia central sensitization osteoarthritis pain. Diseases of the musculoskeletal system RC925-935
spellingShingle	knee osteoarthritis fibromyalgia central sensitization osteoarthritis pain. Diseases of the musculoskeletal system RC925-935 Mahgoub MY Elnady BM Abdelkader HS Abdelhalem RA Hassan WA Comorbidity of Fibromyalgia in Primary Knee Osteoarthritis: Potential Impact on Functional Status and Quality of Life
description	Marwa Yahia Mahgoub,1 Basant Mohamed Elnady,1 Haytham Sayed Abdelkader,2 Raghdaa Abdelkhaleq Abdelhalem,2 Waleed Ahmed Hassan1 1Rheumatology, Rehabilitation and Physical Medicine Department, Benha University, Benha, Egypt; 2Neuropsychiatry Department, Benha University, Benha, EgyptCorrespondence: Marwa Yahia Mahgoub Email marwa.yahia@fmed.bu.edu.egBackground: Knee osteoarthritis (OA) is a painful condition with peripheral and central pain transmission. Fibromyalgia (FM) is the role model of central sensitization of pain perception.Aim: To assess the frequency of FM in knee OA patients and evaluate the impact of FM on mental health and the quality of life in knee OA patients.Patients and Methods: A total of 121 female patients were recruited and divided into 3 groups: group I of 59 patients with knee OA only, group II of 32 patients with knee OA and FM, and group III of 30 FM patients. Patients underwent history taking, examination, investigations, and radiological evaluation of both knees. The assessment of visual analog scale (VAS), Pittsburgh Sleep Quality Index (PSQI), Pain Anxiety Symptom Scale Short Form 20 (PASS20), Beck Depression Inventory (BDI-II), and PCASEE questionnaire were done for all patients. Lequesne index of knee OA and radiological Kellgren and Lawrence score severity were done for all OA patients. Fibromyalgia Impact Questionnaire (FIQ) was assessed for all FM patients.Results: FM was diagnosed in 35.5% of knee OA patients. Group II patients had higher VAS, PASS-20, PSQI, and lower quality of life than either groups I and III, elevated Lequesne index score than group I, significant correlation between VAS and BMI (p=0.002), Lequesne index score (p< 0.001), PASS20 (p=0.006), BDI-II score (p=0.002), and FIQ (P< 0.001), and a negative correlation was found between VAS and physical (p< 0.001), anxiety (p=0.046), and social (p=0.026) QoL parameters. Univariable regression analysis showed a higher age, VAS, PSQI, PASS20, and FIQ were associated with lower QoL in group II. A higher PASS20 was the only predictor of lower QoL in multivariable analysis.Conclusion: Fibromyalgia coexists frequently in knee OA patients and has implications on their mental health, functional activity, and quality of life.Keywords: knee osteoarthritis, fibromyalgia, central sensitization, osteoarthritis pain
format	article
author	Mahgoub MY Elnady BM Abdelkader HS Abdelhalem RA Hassan WA
author_facet	Mahgoub MY Elnady BM Abdelkader HS Abdelhalem RA Hassan WA
author_sort	Mahgoub MY
title	Comorbidity of Fibromyalgia in Primary Knee Osteoarthritis: Potential Impact on Functional Status and Quality of Life
title_short	Comorbidity of Fibromyalgia in Primary Knee Osteoarthritis: Potential Impact on Functional Status and Quality of Life
title_full	Comorbidity of Fibromyalgia in Primary Knee Osteoarthritis: Potential Impact on Functional Status and Quality of Life
title_fullStr	Comorbidity of Fibromyalgia in Primary Knee Osteoarthritis: Potential Impact on Functional Status and Quality of Life
title_full_unstemmed	Comorbidity of Fibromyalgia in Primary Knee Osteoarthritis: Potential Impact on Functional Status and Quality of Life
title_sort	comorbidity of fibromyalgia in primary knee osteoarthritis: potential impact on functional status and quality of life
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/1101f92dd26143798ed2c652e894d3ab
work_keys_str_mv	AT mahgoubmy comorbidityoffibromyalgiainprimarykneeosteoarthritispotentialimpactonfunctionalstatusandqualityoflife AT elnadybm comorbidityoffibromyalgiainprimarykneeosteoarthritispotentialimpactonfunctionalstatusandqualityoflife AT abdelkaderhs comorbidityoffibromyalgiainprimarykneeosteoarthritispotentialimpactonfunctionalstatusandqualityoflife AT abdelhalemra comorbidityoffibromyalgiainprimarykneeosteoarthritispotentialimpactonfunctionalstatusandqualityoflife AT hassanwa comorbidityoffibromyalgiainprimarykneeosteoarthritispotentialimpactonfunctionalstatusandqualityoflife
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Comorbidity of Fibromyalgia in Primary Knee Osteoarthritis: Potential Impact on Functional Status and Quality of Life

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