The role of leptospiremia and specific immune response in severe leptospirosis
Abstract Leptospirosis can cause a high mortality rate, especially in severe cases. This multicenter cross-sectional study aimed to examine both host and pathogen factors that might contribute to the disease severity. A total of 217 leptospirosis patients were recruited and divided into two groups o...
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Nature Portfolio
2021
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oai:doaj.org-article:1101fa28f4054ffba60a3aa81ca3d5a32021-12-02T15:33:00ZThe role of leptospiremia and specific immune response in severe leptospirosis10.1038/s41598-021-94073-z2045-2322https://doaj.org/article/1101fa28f4054ffba60a3aa81ca3d5a32021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94073-zhttps://doaj.org/toc/2045-2322Abstract Leptospirosis can cause a high mortality rate, especially in severe cases. This multicenter cross-sectional study aimed to examine both host and pathogen factors that might contribute to the disease severity. A total of 217 leptospirosis patients were recruited and divided into two groups of non-severe and severe. Severe leptospirosis was defined by a modified sequential organ failure assessment (mSOFA) score of more than two or needed for mechanical ventilation support or had pulmonary hemorrhage or death. We found that leptospiremia, plasma neutrophil gelatinase-associated lipocalin (pNGAL), and interleukin 6 (IL-6) at the first day of enrollment (day 1) and microscopic agglutination test (MAT) titer at 7 days after enrollment (days 7) were significantly higher in the severe group than in the non-severe group. After adjustment for age, gender, and the days of fever, there were statistically significant associations of baseline leptospiremia level (OR 1.70, 95% CI 1.23–2.34, p = 0.001), pNGAL (OR 9.46, 95% CI 4.20–21.33, p < 0.001), and IL-6 (OR 2.82, 95% CI 1.96–4.07, p < 0.001) with the severity. In conclusion, a high leptospiremia, pNGAL, and IL-6 level at baseline were associated with severe leptospirosis.Umaporn LimothaiNuttha LumlertgulPhatadon SirivongrangsonWin KulvichitSasipha TachaboonJanejira DinhuzenWatchadaporn ChaisuriyongSadudee PeerapornratanaChintana ChirathawornKearkiat PraditpornsilpaSomchai Eiam-OngKriang TungsangaNattachai SrisawatNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021) |
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Medicine R Science Q Umaporn Limothai Nuttha Lumlertgul Phatadon Sirivongrangson Win Kulvichit Sasipha Tachaboon Janejira Dinhuzen Watchadaporn Chaisuriyong Sadudee Peerapornratana Chintana Chirathaworn Kearkiat Praditpornsilpa Somchai Eiam-Ong Kriang Tungsanga Nattachai Srisawat The role of leptospiremia and specific immune response in severe leptospirosis |
| description |
Abstract Leptospirosis can cause a high mortality rate, especially in severe cases. This multicenter cross-sectional study aimed to examine both host and pathogen factors that might contribute to the disease severity. A total of 217 leptospirosis patients were recruited and divided into two groups of non-severe and severe. Severe leptospirosis was defined by a modified sequential organ failure assessment (mSOFA) score of more than two or needed for mechanical ventilation support or had pulmonary hemorrhage or death. We found that leptospiremia, plasma neutrophil gelatinase-associated lipocalin (pNGAL), and interleukin 6 (IL-6) at the first day of enrollment (day 1) and microscopic agglutination test (MAT) titer at 7 days after enrollment (days 7) were significantly higher in the severe group than in the non-severe group. After adjustment for age, gender, and the days of fever, there were statistically significant associations of baseline leptospiremia level (OR 1.70, 95% CI 1.23–2.34, p = 0.001), pNGAL (OR 9.46, 95% CI 4.20–21.33, p < 0.001), and IL-6 (OR 2.82, 95% CI 1.96–4.07, p < 0.001) with the severity. In conclusion, a high leptospiremia, pNGAL, and IL-6 level at baseline were associated with severe leptospirosis. |
| format |
article |
| author |
Umaporn Limothai Nuttha Lumlertgul Phatadon Sirivongrangson Win Kulvichit Sasipha Tachaboon Janejira Dinhuzen Watchadaporn Chaisuriyong Sadudee Peerapornratana Chintana Chirathaworn Kearkiat Praditpornsilpa Somchai Eiam-Ong Kriang Tungsanga Nattachai Srisawat |
| author_facet |
Umaporn Limothai Nuttha Lumlertgul Phatadon Sirivongrangson Win Kulvichit Sasipha Tachaboon Janejira Dinhuzen Watchadaporn Chaisuriyong Sadudee Peerapornratana Chintana Chirathaworn Kearkiat Praditpornsilpa Somchai Eiam-Ong Kriang Tungsanga Nattachai Srisawat |
| author_sort |
Umaporn Limothai |
| title |
The role of leptospiremia and specific immune response in severe leptospirosis |
| title_short |
The role of leptospiremia and specific immune response in severe leptospirosis |
| title_full |
The role of leptospiremia and specific immune response in severe leptospirosis |
| title_fullStr |
The role of leptospiremia and specific immune response in severe leptospirosis |
| title_full_unstemmed |
The role of leptospiremia and specific immune response in severe leptospirosis |
| title_sort |
role of leptospiremia and specific immune response in severe leptospirosis |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/1101fa28f4054ffba60a3aa81ca3d5a3 |
| work_keys_str_mv |
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1718387127911186432 |