Decreased B lymphocytes subpopulations are associated with higher atherosclerotic risk in elderly patients with moderate-to-severe chronic kidney diseases

Abstract Aim Cardiovascular diseases (CVD) are the leading cause of death in patients with chronic kidney disease (CKD), and the risk of CVD increases with reductions in renal function. This study aims to investigate the potential roles of B lymphocyte populations in subclinical atherosclerosis (mea...

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Autores principales:	Jieshan Lin, Bin Tang, Zhanwu Feng, Wenke Hao, Wenxue Hu
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	B cells Atherosclerosis Intima-media thickness Elderly Chronic kidney disease Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/1104e0bf213d4e94b74f5162be55339a
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spelling	oai:doaj.org-article:1104e0bf213d4e94b74f5162be55339a2021-12-05T12:26:00ZDecreased B lymphocytes subpopulations are associated with higher atherosclerotic risk in elderly patients with moderate-to-severe chronic kidney diseases10.1186/s12882-021-02613-61471-2369https://doaj.org/article/1104e0bf213d4e94b74f5162be55339a2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12882-021-02613-6https://doaj.org/toc/1471-2369Abstract Aim Cardiovascular diseases (CVD) are the leading cause of death in patients with chronic kidney disease (CKD), and the risk of CVD increases with reductions in renal function. This study aims to investigate the potential roles of B lymphocyte populations in subclinical atherosclerosis (measured by intima-media thickness, IMT) and prognosis in elderly patients with moderate-to-severe CKD. Methods In this study, a total of 219 patients (143 moderate-to-severe CKD patients with stage 3–4 and 76 non-CKD controls) were recruited. B cell subsets: CD19(+)CD5(+) and CD19(+)CD5(−) B cells were analyzed by flow cytometry. Intima-media thickness (IMT) was measured by ultrasound. Correlations between the B cell subsets with IMT and clinical outcome was analyzed. Results CKD patients showed increased IMT (P = 0.006). The level of CD19(+)CD5(+) and CD19(+)CD5(−) B cells were decreased in CKD patients. Correlation analysis showed that IMT was positively correlated with systolic blood pressure, protein/creatinine ratio and diabetes (P < 0.05), and were negatively correlated with CD19(+)CD5(+) and CD19(+)CD5(−) B lymphocytes (P < 0.05). Stepwise multiple regression analysis showed that CD19(+)CD5(−) B cells had a significant independent association with IMT (P < 0.05). IMT was increased in lower level of total CD19(+) B cells (≤ 0.06 × 109 /L) and CD19(+)CD5(−) B cells (≤ 0.05 × 109 /L) (P < 0.05). Kaplan-Meier analysis showed that patients with lower levels of CD19(+)CD5(+) and CD19(+)CD5(−) B cells exhibited worse survival (P < 0.05). Cox regression analysis showed that patients with lower CD19(+)CD5(+) and CD19(+)CD5(−) B cells counts have a higher risk of all-cause mortality (P < 0.05). Conclusions Our results showed that decreased CD19(+)CD5(+) and CD19(+)CD5(−) B lymphocytes were correlated with atherosclerosis and worse survival, which indicates that B lymphocytes might involve in atherosclerosis and associated the prognosis of elderly patients with moderate-to-severe CKD.Jieshan LinBin TangZhanwu FengWenke HaoWenxue HuBMCarticleB cellsAtherosclerosisIntima-media thicknessElderlyChronic kidney diseaseDiseases of the genitourinary system. UrologyRC870-923ENBMC Nephrology, Vol 22, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	B cells Atherosclerosis Intima-media thickness Elderly Chronic kidney disease Diseases of the genitourinary system. Urology RC870-923
spellingShingle	B cells Atherosclerosis Intima-media thickness Elderly Chronic kidney disease Diseases of the genitourinary system. Urology RC870-923 Jieshan Lin Bin Tang Zhanwu Feng Wenke Hao Wenxue Hu Decreased B lymphocytes subpopulations are associated with higher atherosclerotic risk in elderly patients with moderate-to-severe chronic kidney diseases
description	Abstract Aim Cardiovascular diseases (CVD) are the leading cause of death in patients with chronic kidney disease (CKD), and the risk of CVD increases with reductions in renal function. This study aims to investigate the potential roles of B lymphocyte populations in subclinical atherosclerosis (measured by intima-media thickness, IMT) and prognosis in elderly patients with moderate-to-severe CKD. Methods In this study, a total of 219 patients (143 moderate-to-severe CKD patients with stage 3–4 and 76 non-CKD controls) were recruited. B cell subsets: CD19(+)CD5(+) and CD19(+)CD5(−) B cells were analyzed by flow cytometry. Intima-media thickness (IMT) was measured by ultrasound. Correlations between the B cell subsets with IMT and clinical outcome was analyzed. Results CKD patients showed increased IMT (P = 0.006). The level of CD19(+)CD5(+) and CD19(+)CD5(−) B cells were decreased in CKD patients. Correlation analysis showed that IMT was positively correlated with systolic blood pressure, protein/creatinine ratio and diabetes (P < 0.05), and were negatively correlated with CD19(+)CD5(+) and CD19(+)CD5(−) B lymphocytes (P < 0.05). Stepwise multiple regression analysis showed that CD19(+)CD5(−) B cells had a significant independent association with IMT (P < 0.05). IMT was increased in lower level of total CD19(+) B cells (≤ 0.06 × 109 /L) and CD19(+)CD5(−) B cells (≤ 0.05 × 109 /L) (P < 0.05). Kaplan-Meier analysis showed that patients with lower levels of CD19(+)CD5(+) and CD19(+)CD5(−) B cells exhibited worse survival (P < 0.05). Cox regression analysis showed that patients with lower CD19(+)CD5(+) and CD19(+)CD5(−) B cells counts have a higher risk of all-cause mortality (P < 0.05). Conclusions Our results showed that decreased CD19(+)CD5(+) and CD19(+)CD5(−) B lymphocytes were correlated with atherosclerosis and worse survival, which indicates that B lymphocytes might involve in atherosclerosis and associated the prognosis of elderly patients with moderate-to-severe CKD.
format	article
author	Jieshan Lin Bin Tang Zhanwu Feng Wenke Hao Wenxue Hu
author_facet	Jieshan Lin Bin Tang Zhanwu Feng Wenke Hao Wenxue Hu
author_sort	Jieshan Lin
title	Decreased B lymphocytes subpopulations are associated with higher atherosclerotic risk in elderly patients with moderate-to-severe chronic kidney diseases
title_short	Decreased B lymphocytes subpopulations are associated with higher atherosclerotic risk in elderly patients with moderate-to-severe chronic kidney diseases
title_full	Decreased B lymphocytes subpopulations are associated with higher atherosclerotic risk in elderly patients with moderate-to-severe chronic kidney diseases
title_fullStr	Decreased B lymphocytes subpopulations are associated with higher atherosclerotic risk in elderly patients with moderate-to-severe chronic kidney diseases
title_full_unstemmed	Decreased B lymphocytes subpopulations are associated with higher atherosclerotic risk in elderly patients with moderate-to-severe chronic kidney diseases
title_sort	decreased b lymphocytes subpopulations are associated with higher atherosclerotic risk in elderly patients with moderate-to-severe chronic kidney diseases
publisher	BMC
publishDate	2021
url	https://doaj.org/article/1104e0bf213d4e94b74f5162be55339a
work_keys_str_mv	AT jieshanlin decreasedblymphocytessubpopulationsareassociatedwithhigheratheroscleroticriskinelderlypatientswithmoderatetoseverechronickidneydiseases AT bintang decreasedblymphocytessubpopulationsareassociatedwithhigheratheroscleroticriskinelderlypatientswithmoderatetoseverechronickidneydiseases AT zhanwufeng decreasedblymphocytessubpopulationsareassociatedwithhigheratheroscleroticriskinelderlypatientswithmoderatetoseverechronickidneydiseases AT wenkehao decreasedblymphocytessubpopulationsareassociatedwithhigheratheroscleroticriskinelderlypatientswithmoderatetoseverechronickidneydiseases AT wenxuehu decreasedblymphocytessubpopulationsareassociatedwithhigheratheroscleroticriskinelderlypatientswithmoderatetoseverechronickidneydiseases
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Decreased B lymphocytes subpopulations are associated with higher atherosclerotic risk in elderly patients with moderate-to-severe chronic kidney diseases

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