Six-month results of intravitreal ranibizumab for macular edema after branch retinal vein occlusion in a single-center prospective study: visual outcomes and microaneurysm formation

Mihoko Kawamura, Yoshio Hirano, Munenori Yoshida, Takeshi Mizutani, Kazuhiko Sugitani, Tsutomu Yasukawa, Yuichiro Ogura Department of Ophthalmology & Visual Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan Purpose: The aim of this study is to report the 6-...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kawamura M, Hirano Y, Yoshida M, Mizutani T, Sugitani K, Yasukawa T, Ogura Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	branch retinal vein occlusion macular edema microaneurysm ranibizumab Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/110964b6729440d2bf9e055bee5f4980
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:110964b6729440d2bf9e055bee5f4980
record_format	dspace
spelling	oai:doaj.org-article:110964b6729440d2bf9e055bee5f49802021-12-02T03:32:36ZSix-month results of intravitreal ranibizumab for macular edema after branch retinal vein occlusion in a single-center prospective study: visual outcomes and microaneurysm formation1177-5483https://doaj.org/article/110964b6729440d2bf9e055bee5f49802018-08-01T00:00:00Zhttps://www.dovepress.com/six-month-results-of-intravitreal-ranibizumab-for-macular-edema-after--peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Mihoko Kawamura, Yoshio Hirano, Munenori Yoshida, Takeshi Mizutani, Kazuhiko Sugitani, Tsutomu Yasukawa, Yuichiro Ogura Department of Ophthalmology & Visual Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan Purpose: The aim of this study is to report the 6-month results after one intravitreal ranibizumab (IVR) injection followed by pro re nata dosing for macular edema (ME) after branch retinal vein occlusion.Patients and methods: The inclusion criteria included a minimal patient age of 18 years, 20 letters or more best-corrected visual acuity (BCVA) (Early Treatment Diabetic Retinopathy Study [ETDRS] score, 77 letters or less), and central retinal thickness (CRT) of 250 microns or more. The primary outcome measure was the mean BCVA change from baseline at month 6; the secondary outcomes were mean changes in CRT, residual ME, and microaneurysm formation.Results: Twenty patients were enrolled from March 2014 through October 2016 at Nagoya City University Hospital. The baseline mean ETDRS letters and CRT were 63.1 and 500 microns, respectively; mean time from symptom onset to initial therapy was 1.80 months; and mean ETDRS gain and CRT reduction were 15.2 letters and 230 microns, respectively. The percentages of patients with Snellen equivalent BCVAs of 20/40 (70 ETDRS letters) or better and 20/20 (85 ETDRS letters) were 90% and 15%, respectively. Residual ME and microaneurysms were observed in 85% and 35% of patients. Microaneurysm formation was associated with delayed initial therapy.Conclusion: Prompt initiation of IVR injection provided a better visual prognosis at month 6 and suppressed the microaneurysm formation. Keywords: branch retinal vein occlusion, macular edema, microaneurysm, ranibizumab, prompt treatmentKawamura MHirano YYoshida MMizutani TSugitani KYasukawa TOgura YDove Medical Pressarticlebranch retinal vein occlusionmacular edemamicroaneurysmranibizumabOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 12, Pp 1487-1494 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	branch retinal vein occlusion macular edema microaneurysm ranibizumab Ophthalmology RE1-994
spellingShingle	branch retinal vein occlusion macular edema microaneurysm ranibizumab Ophthalmology RE1-994 Kawamura M Hirano Y Yoshida M Mizutani T Sugitani K Yasukawa T Ogura Y Six-month results of intravitreal ranibizumab for macular edema after branch retinal vein occlusion in a single-center prospective study: visual outcomes and microaneurysm formation
description	Mihoko Kawamura, Yoshio Hirano, Munenori Yoshida, Takeshi Mizutani, Kazuhiko Sugitani, Tsutomu Yasukawa, Yuichiro Ogura Department of Ophthalmology & Visual Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan Purpose: The aim of this study is to report the 6-month results after one intravitreal ranibizumab (IVR) injection followed by pro re nata dosing for macular edema (ME) after branch retinal vein occlusion.Patients and methods: The inclusion criteria included a minimal patient age of 18 years, 20 letters or more best-corrected visual acuity (BCVA) (Early Treatment Diabetic Retinopathy Study [ETDRS] score, 77 letters or less), and central retinal thickness (CRT) of 250 microns or more. The primary outcome measure was the mean BCVA change from baseline at month 6; the secondary outcomes were mean changes in CRT, residual ME, and microaneurysm formation.Results: Twenty patients were enrolled from March 2014 through October 2016 at Nagoya City University Hospital. The baseline mean ETDRS letters and CRT were 63.1 and 500 microns, respectively; mean time from symptom onset to initial therapy was 1.80 months; and mean ETDRS gain and CRT reduction were 15.2 letters and 230 microns, respectively. The percentages of patients with Snellen equivalent BCVAs of 20/40 (70 ETDRS letters) or better and 20/20 (85 ETDRS letters) were 90% and 15%, respectively. Residual ME and microaneurysms were observed in 85% and 35% of patients. Microaneurysm formation was associated with delayed initial therapy.Conclusion: Prompt initiation of IVR injection provided a better visual prognosis at month 6 and suppressed the microaneurysm formation. Keywords: branch retinal vein occlusion, macular edema, microaneurysm, ranibizumab, prompt treatment
format	article
author	Kawamura M Hirano Y Yoshida M Mizutani T Sugitani K Yasukawa T Ogura Y
author_facet	Kawamura M Hirano Y Yoshida M Mizutani T Sugitani K Yasukawa T Ogura Y
author_sort	Kawamura M
title	Six-month results of intravitreal ranibizumab for macular edema after branch retinal vein occlusion in a single-center prospective study: visual outcomes and microaneurysm formation
title_short	Six-month results of intravitreal ranibizumab for macular edema after branch retinal vein occlusion in a single-center prospective study: visual outcomes and microaneurysm formation
title_full	Six-month results of intravitreal ranibizumab for macular edema after branch retinal vein occlusion in a single-center prospective study: visual outcomes and microaneurysm formation
title_fullStr	Six-month results of intravitreal ranibizumab for macular edema after branch retinal vein occlusion in a single-center prospective study: visual outcomes and microaneurysm formation
title_full_unstemmed	Six-month results of intravitreal ranibizumab for macular edema after branch retinal vein occlusion in a single-center prospective study: visual outcomes and microaneurysm formation
title_sort	six-month results of intravitreal ranibizumab for macular edema after branch retinal vein occlusion in a single-center prospective study: visual outcomes and microaneurysm formation
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/110964b6729440d2bf9e055bee5f4980
work_keys_str_mv	AT kawamuram sixmonthresultsofintravitrealranibizumabformacularedemaafterbranchretinalveinocclusioninasinglecenterprospectivestudyvisualoutcomesandmicroaneurysmformation AT hiranoy sixmonthresultsofintravitrealranibizumabformacularedemaafterbranchretinalveinocclusioninasinglecenterprospectivestudyvisualoutcomesandmicroaneurysmformation AT yoshidam sixmonthresultsofintravitrealranibizumabformacularedemaafterbranchretinalveinocclusioninasinglecenterprospectivestudyvisualoutcomesandmicroaneurysmformation AT mizutanit sixmonthresultsofintravitrealranibizumabformacularedemaafterbranchretinalveinocclusioninasinglecenterprospectivestudyvisualoutcomesandmicroaneurysmformation AT sugitanik sixmonthresultsofintravitrealranibizumabformacularedemaafterbranchretinalveinocclusioninasinglecenterprospectivestudyvisualoutcomesandmicroaneurysmformation AT yasukawat sixmonthresultsofintravitrealranibizumabformacularedemaafterbranchretinalveinocclusioninasinglecenterprospectivestudyvisualoutcomesandmicroaneurysmformation AT oguray sixmonthresultsofintravitrealranibizumabformacularedemaafterbranchretinalveinocclusioninasinglecenterprospectivestudyvisualoutcomesandmicroaneurysmformation
_version_	1718401713582374912

Six-month results of intravitreal ranibizumab for macular edema after branch retinal vein occlusion in a single-center prospective study: visual outcomes and microaneurysm formation

Ejemplares similares