Malignancy-induced hemophagocytic lymphohistiocytosis in a case of signet ring cell carcinoma of the stomach

Hemophagocytic lymphohistiocytosis (HLH) is a rare and potentially life-threatening condition associated with high mortality and can be classified into primary (familial) and secondary HLH. Primary HLH is an inherited, autosomal recessive disorder associated with defects in perforin function, wherea...

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Autor principal:	Subramaniam Ramkumar
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2021
Materias:	hemophagocytosis malignancy malignancy-associated hemophagocytic lymphohistiocytosis reactive hemophagocytosis secondary hemophagocytic lymphohistiocytosis signet-ring cell carcinoma Pathology RB1-214 Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/110b02c1b45745cc94a295947c456b01
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spelling	oai:doaj.org-article:110b02c1b45745cc94a295947c456b012021-12-02T17:49:10ZMalignancy-induced hemophagocytic lymphohistiocytosis in a case of signet ring cell carcinoma of the stomach0377-492910.4103/IJPM.IJPM_896_19https://doaj.org/article/110b02c1b45745cc94a295947c456b012021-01-01T00:00:00Zhttp://www.ijpmonline.org/article.asp?issn=0377-4929;year=2021;volume=64;issue=5;spage=85;epage=88;aulast=Ramkumarhttps://doaj.org/toc/0377-4929Hemophagocytic lymphohistiocytosis (HLH) is a rare and potentially life-threatening condition associated with high mortality and can be classified into primary (familial) and secondary HLH. Primary HLH is an inherited, autosomal recessive disorder associated with defects in perforin function, whereas secondary HLH is associated with infections, especially Epstein–Barr virus infection, malignancies, and autoimmune disorders. Patients with malignancy-associated secondary HLH experience symptoms that overlap with those described for other HLH types, which is associated with an increased incidence of misdiagnosis and mortality. Here, we report the case of a patient with secondary HLH associated with a solid malignancy (signet-ring cell carcinoma of the stomach).Subramaniam RamkumarWolters Kluwer Medknow Publicationsarticlehemophagocytosismalignancymalignancy-associated hemophagocytic lymphohistiocytosisreactive hemophagocytosissecondary hemophagocytic lymphohistiocytosissignet-ring cell carcinomaPathologyRB1-214MicrobiologyQR1-502ENIndian Journal of Pathology and Microbiology, Vol 64, Iss 5, Pp 85-88 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hemophagocytosis malignancy malignancy-associated hemophagocytic lymphohistiocytosis reactive hemophagocytosis secondary hemophagocytic lymphohistiocytosis signet-ring cell carcinoma Pathology RB1-214 Microbiology QR1-502
spellingShingle	hemophagocytosis malignancy malignancy-associated hemophagocytic lymphohistiocytosis reactive hemophagocytosis secondary hemophagocytic lymphohistiocytosis signet-ring cell carcinoma Pathology RB1-214 Microbiology QR1-502 Subramaniam Ramkumar Malignancy-induced hemophagocytic lymphohistiocytosis in a case of signet ring cell carcinoma of the stomach
description	Hemophagocytic lymphohistiocytosis (HLH) is a rare and potentially life-threatening condition associated with high mortality and can be classified into primary (familial) and secondary HLH. Primary HLH is an inherited, autosomal recessive disorder associated with defects in perforin function, whereas secondary HLH is associated with infections, especially Epstein–Barr virus infection, malignancies, and autoimmune disorders. Patients with malignancy-associated secondary HLH experience symptoms that overlap with those described for other HLH types, which is associated with an increased incidence of misdiagnosis and mortality. Here, we report the case of a patient with secondary HLH associated with a solid malignancy (signet-ring cell carcinoma of the stomach).
format	article
author	Subramaniam Ramkumar
author_facet	Subramaniam Ramkumar
author_sort	Subramaniam Ramkumar
title	Malignancy-induced hemophagocytic lymphohistiocytosis in a case of signet ring cell carcinoma of the stomach
title_short	Malignancy-induced hemophagocytic lymphohistiocytosis in a case of signet ring cell carcinoma of the stomach
title_full	Malignancy-induced hemophagocytic lymphohistiocytosis in a case of signet ring cell carcinoma of the stomach
title_fullStr	Malignancy-induced hemophagocytic lymphohistiocytosis in a case of signet ring cell carcinoma of the stomach
title_full_unstemmed	Malignancy-induced hemophagocytic lymphohistiocytosis in a case of signet ring cell carcinoma of the stomach
title_sort	malignancy-induced hemophagocytic lymphohistiocytosis in a case of signet ring cell carcinoma of the stomach
publisher	Wolters Kluwer Medknow Publications
publishDate	2021
url	https://doaj.org/article/110b02c1b45745cc94a295947c456b01
work_keys_str_mv	AT subramaniamramkumar malignancyinducedhemophagocyticlymphohistiocytosisinacaseofsignetringcellcarcinomaofthestomach
_version_	1718379450017513472

Malignancy-induced hemophagocytic lymphohistiocytosis in a case of signet ring cell carcinoma of the stomach

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