SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues

Summary: Variability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to genetic factors. Here, we identify 4 genomic loci with suggestive associations for SARS-CoV-2 susceptibility and 19 for COVID-19 disease severity. Four of these 23 loci likely have an...

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Autores principales:	Matteo D’Antonio, Jennifer P. Nguyen, Timothy D. Arthur, Hiroko Matsui, Agnieszka D’Antonio-Chronowska, Kelly A. Frazer
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	COVID-19 SARS-CoV-2 GWAS eQTL colocalization Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/110f8abe7f0747459d4198d2e8a6080d
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spelling	oai:doaj.org-article:110f8abe7f0747459d4198d2e8a6080d2021-11-18T04:47:58ZSARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues2211-124710.1016/j.celrep.2021.110020https://doaj.org/article/110f8abe7f0747459d4198d2e8a6080d2021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2211124721015023https://doaj.org/toc/2211-1247Summary: Variability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to genetic factors. Here, we identify 4 genomic loci with suggestive associations for SARS-CoV-2 susceptibility and 19 for COVID-19 disease severity. Four of these 23 loci likely have an ethnicity-specific component. Genome-wide association study (GWAS) signals in 11 loci colocalize with expression quantitative trait loci (eQTLs) associated with the expression of 20 genes in 62 tissues/cell types (range: 1:43 tissues/gene), including lung, brain, heart, muscle, and skin as well as the digestive system and immune system. We perform genetic fine mapping to compute 99% credible SNP sets, which identify 10 GWAS loci that have eight or fewer SNPs in the credible set, including three loci with one single likely causal SNP. Our study suggests that the diverse symptoms and disease severity of COVID-19 observed between individuals is associated with variants across the genome, affecting gene expression levels in a wide variety of tissue types.Matteo D’AntonioJennifer P. NguyenTimothy D. ArthurHiroko MatsuiAgnieszka D’Antonio-ChronowskaKelly A. FrazerElsevierarticleCOVID-19SARS-CoV-2GWASeQTLcolocalizationBiology (General)QH301-705.5ENCell Reports, Vol 37, Iss 7, Pp 110020- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 SARS-CoV-2 GWAS eQTL colocalization Biology (General) QH301-705.5
spellingShingle	COVID-19 SARS-CoV-2 GWAS eQTL colocalization Biology (General) QH301-705.5 Matteo D’Antonio Jennifer P. Nguyen Timothy D. Arthur Hiroko Matsui Agnieszka D’Antonio-Chronowska Kelly A. Frazer SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues
description	Summary: Variability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to genetic factors. Here, we identify 4 genomic loci with suggestive associations for SARS-CoV-2 susceptibility and 19 for COVID-19 disease severity. Four of these 23 loci likely have an ethnicity-specific component. Genome-wide association study (GWAS) signals in 11 loci colocalize with expression quantitative trait loci (eQTLs) associated with the expression of 20 genes in 62 tissues/cell types (range: 1:43 tissues/gene), including lung, brain, heart, muscle, and skin as well as the digestive system and immune system. We perform genetic fine mapping to compute 99% credible SNP sets, which identify 10 GWAS loci that have eight or fewer SNPs in the credible set, including three loci with one single likely causal SNP. Our study suggests that the diverse symptoms and disease severity of COVID-19 observed between individuals is associated with variants across the genome, affecting gene expression levels in a wide variety of tissue types.
format	article
author	Matteo D’Antonio Jennifer P. Nguyen Timothy D. Arthur Hiroko Matsui Agnieszka D’Antonio-Chronowska Kelly A. Frazer
author_facet	Matteo D’Antonio Jennifer P. Nguyen Timothy D. Arthur Hiroko Matsui Agnieszka D’Antonio-Chronowska Kelly A. Frazer
author_sort	Matteo D’Antonio
title	SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues
title_short	SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues
title_full	SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues
title_fullStr	SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues
title_full_unstemmed	SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues
title_sort	sars-cov-2 susceptibility and covid-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/110f8abe7f0747459d4198d2e8a6080d
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SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues

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