Comparative Effects of Dexamethasone and Meloxicam on Magnitude of the Acute Inflammatory Response Induced by Escherichia coli Lipopolysaccharide in Broiler Chickens

Mohadeseh Manzari Tavakoli, Bahman Abdi-Hachesoo, Saeed Nazifi, Najmeh Mosleh, Seyedeh Alemeh Hosseinian, Peyman Nakhaee Department of Clinical Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, IranCorrespondence: Bahman Abdi-Hachesoo Email abdi@shirazu.ac.irPurpose: Dexamethasone...

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Autores principales:	Manzari Tavakoli M, Abdi-Hachesoo B, Nazifi S, Mosleh N, Hosseinian SA, Nakhaee P
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	lipopolysaccharide meloxicam dexamethasone interleukin-6 acute phase proteins chickens Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/1110af9c97fd4e9faf8af70ee88eef47
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spelling	oai:doaj.org-article:1110af9c97fd4e9faf8af70ee88eef472021-12-02T09:31:04ZComparative Effects of Dexamethasone and Meloxicam on Magnitude of the Acute Inflammatory Response Induced by Escherichia coli Lipopolysaccharide in Broiler Chickens1178-7031https://doaj.org/article/1110af9c97fd4e9faf8af70ee88eef472020-08-01T00:00:00Zhttps://www.dovepress.com/comparative-effects-of-dexamethasone-and-meloxicam-on-magnitude-of-the-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Mohadeseh Manzari Tavakoli, Bahman Abdi-Hachesoo, Saeed Nazifi, Najmeh Mosleh, Seyedeh Alemeh Hosseinian, Peyman Nakhaee Department of Clinical Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, IranCorrespondence: Bahman Abdi-Hachesoo Email abdi@shirazu.ac.irPurpose: Dexamethasone has been widely used to treat acute inflammatory diseases and endotoxic shocks in animal models. Meloxicam is one of the most commonly used anti-inflammatory agents in avian species. However, little is known about the effects of dexamethasone and meloxicam on lipopolysaccharide (LPS)-induced acute inflammatory response in birds. In the present study, LPS-challenged broiler chickens were used to investigate the comparative protective effects of meloxicam and dexamethasone on LPS-induced acute inflammatory responses.Methods: Lipopolysaccharide (LPS)-induced acute lung injury (ALI) histopathological scores, selected serum acute phase reactants, inflammatory mediators, and gangliosides were evaluated in broiler chickens inoculated with E. coli LPS and simultaneously treated with two doses of meloxicam (0.5 and 2 mg/kg BW) and dexamethasone (2 and 4 mg/kg BW).Results: LPS-induced ALI scores were not significantly different between the meloxicam-treated, dexamethasone-treated, and untreated positive control groups at 4 hours after LPS inoculation. Interleukin-6 concentrations were also statistically the same among the positive control, dexamethasone-treated, and meloxicam-treated groups at 3 and 12 hours after LPS inoculation. However, these anti-inflammatory drugs reduced adenosine deaminase, ceruloplasmin, lipid-bound sialic acid, protein-bound sialic acid, and total sialic acid in LPS-inoculated broiler chickens at 12, 24, and 48 hours after LPS inoculation in a drug- and dose-dependent manner. Ovotransferrin concentrations were not significantly different between positive control and treatment groups at 12 hours after LPS inoculation. However, twenty-four hours after LPS inoculation, all the treated groups, except the one treated with 0.5 mg/kg meloxicam, showed significantly lower concentrations of ovotransferrin as compared with the positive control group.Conclusion: Our results showed that dexamethasone was more effective than meloxicam in inhibiting the LPS-induced response in broiler chickens by diminishing the serum levels of adenosine deaminase, ceruloplasmin, and gangliosides.Keywords: lipopolysaccharide, meloxicam, dexamethasone, interleukin-6, acute phase proteins, chickensManzari Tavakoli MAbdi-Hachesoo BNazifi SMosleh NHosseinian SANakhaee PDove Medical Pressarticlelipopolysaccharidemeloxicamdexamethasoneinterleukin-6acute phase proteinschickensPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 13, Pp 487-495 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	lipopolysaccharide meloxicam dexamethasone interleukin-6 acute phase proteins chickens Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	lipopolysaccharide meloxicam dexamethasone interleukin-6 acute phase proteins chickens Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Manzari Tavakoli M Abdi-Hachesoo B Nazifi S Mosleh N Hosseinian SA Nakhaee P Comparative Effects of Dexamethasone and Meloxicam on Magnitude of the Acute Inflammatory Response Induced by Escherichia coli Lipopolysaccharide in Broiler Chickens
description	Mohadeseh Manzari Tavakoli, Bahman Abdi-Hachesoo, Saeed Nazifi, Najmeh Mosleh, Seyedeh Alemeh Hosseinian, Peyman Nakhaee Department of Clinical Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, IranCorrespondence: Bahman Abdi-Hachesoo Email abdi@shirazu.ac.irPurpose: Dexamethasone has been widely used to treat acute inflammatory diseases and endotoxic shocks in animal models. Meloxicam is one of the most commonly used anti-inflammatory agents in avian species. However, little is known about the effects of dexamethasone and meloxicam on lipopolysaccharide (LPS)-induced acute inflammatory response in birds. In the present study, LPS-challenged broiler chickens were used to investigate the comparative protective effects of meloxicam and dexamethasone on LPS-induced acute inflammatory responses.Methods: Lipopolysaccharide (LPS)-induced acute lung injury (ALI) histopathological scores, selected serum acute phase reactants, inflammatory mediators, and gangliosides were evaluated in broiler chickens inoculated with E. coli LPS and simultaneously treated with two doses of meloxicam (0.5 and 2 mg/kg BW) and dexamethasone (2 and 4 mg/kg BW).Results: LPS-induced ALI scores were not significantly different between the meloxicam-treated, dexamethasone-treated, and untreated positive control groups at 4 hours after LPS inoculation. Interleukin-6 concentrations were also statistically the same among the positive control, dexamethasone-treated, and meloxicam-treated groups at 3 and 12 hours after LPS inoculation. However, these anti-inflammatory drugs reduced adenosine deaminase, ceruloplasmin, lipid-bound sialic acid, protein-bound sialic acid, and total sialic acid in LPS-inoculated broiler chickens at 12, 24, and 48 hours after LPS inoculation in a drug- and dose-dependent manner. Ovotransferrin concentrations were not significantly different between positive control and treatment groups at 12 hours after LPS inoculation. However, twenty-four hours after LPS inoculation, all the treated groups, except the one treated with 0.5 mg/kg meloxicam, showed significantly lower concentrations of ovotransferrin as compared with the positive control group.Conclusion: Our results showed that dexamethasone was more effective than meloxicam in inhibiting the LPS-induced response in broiler chickens by diminishing the serum levels of adenosine deaminase, ceruloplasmin, and gangliosides.Keywords: lipopolysaccharide, meloxicam, dexamethasone, interleukin-6, acute phase proteins, chickens
format	article
author	Manzari Tavakoli M Abdi-Hachesoo B Nazifi S Mosleh N Hosseinian SA Nakhaee P
author_facet	Manzari Tavakoli M Abdi-Hachesoo B Nazifi S Mosleh N Hosseinian SA Nakhaee P
author_sort	Manzari Tavakoli M
title	Comparative Effects of Dexamethasone and Meloxicam on Magnitude of the Acute Inflammatory Response Induced by Escherichia coli Lipopolysaccharide in Broiler Chickens
title_short	Comparative Effects of Dexamethasone and Meloxicam on Magnitude of the Acute Inflammatory Response Induced by Escherichia coli Lipopolysaccharide in Broiler Chickens
title_full	Comparative Effects of Dexamethasone and Meloxicam on Magnitude of the Acute Inflammatory Response Induced by Escherichia coli Lipopolysaccharide in Broiler Chickens
title_fullStr	Comparative Effects of Dexamethasone and Meloxicam on Magnitude of the Acute Inflammatory Response Induced by Escherichia coli Lipopolysaccharide in Broiler Chickens
title_full_unstemmed	Comparative Effects of Dexamethasone and Meloxicam on Magnitude of the Acute Inflammatory Response Induced by Escherichia coli Lipopolysaccharide in Broiler Chickens
title_sort	comparative effects of dexamethasone and meloxicam on magnitude of the acute inflammatory response induced by escherichia coli lipopolysaccharide in broiler chickens
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/1110af9c97fd4e9faf8af70ee88eef47
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Comparative Effects of Dexamethasone and Meloxicam on Magnitude of the Acute Inflammatory Response Induced by Escherichia coli Lipopolysaccharide in Broiler Chickens

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