Intra-tumor heterogeneity in head and neck cancer and its clinical implications

The presence of heritable differences among cancer cells within a tumor, called intra-tumor genetic heterogeneity, has long been suspected of playing a role in poor responses to therapy. Research over the past decade has documented the existence of such heterogeneity within tumors of individual pati...

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Autores principales:	Edmund A. Mroz, James W. Rocco
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2016
Materias:	Otorhinolaryngology RF1-547 Surgery RD1-811
Acceso en línea:	https://doaj.org/article/1110db09295a4bc2bf35e97b1e593209
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spelling	oai:doaj.org-article:1110db09295a4bc2bf35e97b1e5932092021-12-02T15:51:49ZIntra-tumor heterogeneity in head and neck cancer and its clinical implications2095-881110.1016/j.wjorl.2016.05.007https://doaj.org/article/1110db09295a4bc2bf35e97b1e5932092016-06-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095881116300191https://doaj.org/toc/2095-8811The presence of heritable differences among cancer cells within a tumor, called intra-tumor genetic heterogeneity, has long been suspected of playing a role in poor responses to therapy. Research over the past decade has documented the existence of such heterogeneity within tumors of individual patients and documented its potential clinical significance. The research methods for identifying this heterogeneity were not, however, readily adaptable to widespread clinical application. After a brief review of this background, we describe the development of a measure of intra-tumor genetic heterogeneity, based on whole-exome sequencing of individual tumor samples, that could be applied to biopsy specimens in a clinical setting. This measure has now been used in head and neck squamous cell carcinoma (HNSCC) to document, for the first time, a relation of high intra-tumor genetic heterogeneity to shorter overall survival in a large, multi-institutional study. The implications of heterogeneity for research and clinical care thus now need to be addressed. Keywords: Head and neck squamous cell carcinoma, Intra-tumor genetic heterogeneity, Next-generation sequencing, Targeted therapyEdmund A. MrozJames W. RoccoKeAi Communications Co., Ltd.articleOtorhinolaryngologyRF1-547SurgeryRD1-811ENWorld Journal of Otorhinolaryngology-Head and Neck Surgery, Vol 2, Iss 2, Pp 60-67 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Otorhinolaryngology RF1-547 Surgery RD1-811
spellingShingle	Otorhinolaryngology RF1-547 Surgery RD1-811 Edmund A. Mroz James W. Rocco Intra-tumor heterogeneity in head and neck cancer and its clinical implications
description	The presence of heritable differences among cancer cells within a tumor, called intra-tumor genetic heterogeneity, has long been suspected of playing a role in poor responses to therapy. Research over the past decade has documented the existence of such heterogeneity within tumors of individual patients and documented its potential clinical significance. The research methods for identifying this heterogeneity were not, however, readily adaptable to widespread clinical application. After a brief review of this background, we describe the development of a measure of intra-tumor genetic heterogeneity, based on whole-exome sequencing of individual tumor samples, that could be applied to biopsy specimens in a clinical setting. This measure has now been used in head and neck squamous cell carcinoma (HNSCC) to document, for the first time, a relation of high intra-tumor genetic heterogeneity to shorter overall survival in a large, multi-institutional study. The implications of heterogeneity for research and clinical care thus now need to be addressed. Keywords: Head and neck squamous cell carcinoma, Intra-tumor genetic heterogeneity, Next-generation sequencing, Targeted therapy
format	article
author	Edmund A. Mroz James W. Rocco
author_facet	Edmund A. Mroz James W. Rocco
author_sort	Edmund A. Mroz
title	Intra-tumor heterogeneity in head and neck cancer and its clinical implications
title_short	Intra-tumor heterogeneity in head and neck cancer and its clinical implications
title_full	Intra-tumor heterogeneity in head and neck cancer and its clinical implications
title_fullStr	Intra-tumor heterogeneity in head and neck cancer and its clinical implications
title_full_unstemmed	Intra-tumor heterogeneity in head and neck cancer and its clinical implications
title_sort	intra-tumor heterogeneity in head and neck cancer and its clinical implications
publisher	KeAi Communications Co., Ltd.
publishDate	2016
url	https://doaj.org/article/1110db09295a4bc2bf35e97b1e593209
work_keys_str_mv	AT edmundamroz intratumorheterogeneityinheadandneckcanceranditsclinicalimplications AT jameswrocco intratumorheterogeneityinheadandneckcanceranditsclinicalimplications
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Intra-tumor heterogeneity in head and neck cancer and its clinical implications

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