Intra-retinal Arterial Cannulation using a Microneedle for Central Retinal Artery Occlusion

Abstract Central retinal artery occlusion (CRAO) is a severe disease, often causing blindness. We evaluated the efficacy and safety of a surgical procedure for the treatment of acute CRAO in which retinal arterial cannulation with tissue plasminogen activator (tPA) is performed. The surgical procedu...

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Autores principales:	Kazuaki Kadonosono, Shin Yamane, Maiko Inoue, Tadashi Yamakawa, Eiichi Uchio
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/111353915eed450684745d840fa43bed
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spelling	oai:doaj.org-article:111353915eed450684745d840fa43bed2021-12-02T15:08:42ZIntra-retinal Arterial Cannulation using a Microneedle for Central Retinal Artery Occlusion10.1038/s41598-018-19747-72045-2322https://doaj.org/article/111353915eed450684745d840fa43bed2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-19747-7https://doaj.org/toc/2045-2322Abstract Central retinal artery occlusion (CRAO) is a severe disease, often causing blindness. We evaluated the efficacy and safety of a surgical procedure for the treatment of acute CRAO in which retinal arterial cannulation with tissue plasminogen activator (tPA) is performed. The surgical procedure consisted of vitrectomy followed by cannulation of the central retinal artery and injection of tPA (200 μg) using a 47-gauge microneedle. Thirteen CRAO patients were treated within 48 hours of the onset of symptoms. The central retinal artery of all 13 eyes was successfully cannulated. The mean interval between the onset of symptoms and surgery was 38.7 hours. The results for all 13 eyes treated showed a statistically significant improvement in mean visual acuity between before and one month after treatment (−1.60 vs. −0.82 logarithmic values for minimum angle resolution (LogMAR), p = 0.0021). Fluorescein angiography showed complete reperfusion and incomplete reperfusion in 10 eyes and 3 eyes, respectively. Recently developed surgical instruments have made retinal-arterial cannulation feasible. Intra-retinal-arterial cannulation has potential as a method of improving visual function and microcirculation in eyes affected by CRAO.Kazuaki KadonosonoShin YamaneMaiko InoueTadashi YamakawaEiichi UchioNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-7 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kazuaki Kadonosono Shin Yamane Maiko Inoue Tadashi Yamakawa Eiichi Uchio Intra-retinal Arterial Cannulation using a Microneedle for Central Retinal Artery Occlusion
description	Abstract Central retinal artery occlusion (CRAO) is a severe disease, often causing blindness. We evaluated the efficacy and safety of a surgical procedure for the treatment of acute CRAO in which retinal arterial cannulation with tissue plasminogen activator (tPA) is performed. The surgical procedure consisted of vitrectomy followed by cannulation of the central retinal artery and injection of tPA (200 μg) using a 47-gauge microneedle. Thirteen CRAO patients were treated within 48 hours of the onset of symptoms. The central retinal artery of all 13 eyes was successfully cannulated. The mean interval between the onset of symptoms and surgery was 38.7 hours. The results for all 13 eyes treated showed a statistically significant improvement in mean visual acuity between before and one month after treatment (−1.60 vs. −0.82 logarithmic values for minimum angle resolution (LogMAR), p = 0.0021). Fluorescein angiography showed complete reperfusion and incomplete reperfusion in 10 eyes and 3 eyes, respectively. Recently developed surgical instruments have made retinal-arterial cannulation feasible. Intra-retinal-arterial cannulation has potential as a method of improving visual function and microcirculation in eyes affected by CRAO.
format	article
author	Kazuaki Kadonosono Shin Yamane Maiko Inoue Tadashi Yamakawa Eiichi Uchio
author_facet	Kazuaki Kadonosono Shin Yamane Maiko Inoue Tadashi Yamakawa Eiichi Uchio
author_sort	Kazuaki Kadonosono
title	Intra-retinal Arterial Cannulation using a Microneedle for Central Retinal Artery Occlusion
title_short	Intra-retinal Arterial Cannulation using a Microneedle for Central Retinal Artery Occlusion
title_full	Intra-retinal Arterial Cannulation using a Microneedle for Central Retinal Artery Occlusion
title_fullStr	Intra-retinal Arterial Cannulation using a Microneedle for Central Retinal Artery Occlusion
title_full_unstemmed	Intra-retinal Arterial Cannulation using a Microneedle for Central Retinal Artery Occlusion
title_sort	intra-retinal arterial cannulation using a microneedle for central retinal artery occlusion
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/111353915eed450684745d840fa43bed
work_keys_str_mv	AT kazuakikadonosono intraretinalarterialcannulationusingamicroneedleforcentralretinalarteryocclusion AT shinyamane intraretinalarterialcannulationusingamicroneedleforcentralretinalarteryocclusion AT maikoinoue intraretinalarterialcannulationusingamicroneedleforcentralretinalarteryocclusion AT tadashiyamakawa intraretinalarterialcannulationusingamicroneedleforcentralretinalarteryocclusion AT eiichiuchio intraretinalarterialcannulationusingamicroneedleforcentralretinalarteryocclusion
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Intra-retinal Arterial Cannulation using a Microneedle for Central Retinal Artery Occlusion

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