Calculating the optimal hematocrit under the constraint of constant cardiac power

Abstract In humans and higher animals, a trade-off between sufficiently high erythrocyte concentrations to bind oxygen and sufficiently low blood viscosity to allow rapid blood flow has been achieved during evolution. Optimal hematocrit theory has been successful in predicting hematocrit (HCT) value...

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Autores principales:	Michal Sitina, Heiko Stark, Stefan Schuster
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1113dc41d63644ffba1af1d719fd554d
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spelling	oai:doaj.org-article:1113dc41d63644ffba1af1d719fd554d2021-12-02T14:21:43ZCalculating the optimal hematocrit under the constraint of constant cardiac power10.1038/s41598-021-83427-22045-2322https://doaj.org/article/1113dc41d63644ffba1af1d719fd554d2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83427-2https://doaj.org/toc/2045-2322Abstract In humans and higher animals, a trade-off between sufficiently high erythrocyte concentrations to bind oxygen and sufficiently low blood viscosity to allow rapid blood flow has been achieved during evolution. Optimal hematocrit theory has been successful in predicting hematocrit (HCT) values of about 0.3–0.5, in very good agreement with the normal values observed for humans and many animal species. However, according to those calculations, the optimal value should be independent of the mechanical load of the body. This is in contradiction to the exertional increase in HCT observed in some animals called natural blood dopers and to the illegal practice of blood boosting in high-performance sports. Here, we present a novel calculation to predict the optimal HCT value under the constraint of constant cardiac power and compare it to the optimal value obtained for constant driving pressure. We show that the optimal HCT under constant power ranges from 0.5 to 0.7, in agreement with observed values in natural blood dopers at exertion. We use this result to explain the tendency to better exertional performance at an increased HCT.Michal SitinaHeiko StarkStefan SchusterNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Michal Sitina Heiko Stark Stefan Schuster Calculating the optimal hematocrit under the constraint of constant cardiac power
description	Abstract In humans and higher animals, a trade-off between sufficiently high erythrocyte concentrations to bind oxygen and sufficiently low blood viscosity to allow rapid blood flow has been achieved during evolution. Optimal hematocrit theory has been successful in predicting hematocrit (HCT) values of about 0.3–0.5, in very good agreement with the normal values observed for humans and many animal species. However, according to those calculations, the optimal value should be independent of the mechanical load of the body. This is in contradiction to the exertional increase in HCT observed in some animals called natural blood dopers and to the illegal practice of blood boosting in high-performance sports. Here, we present a novel calculation to predict the optimal HCT value under the constraint of constant cardiac power and compare it to the optimal value obtained for constant driving pressure. We show that the optimal HCT under constant power ranges from 0.5 to 0.7, in agreement with observed values in natural blood dopers at exertion. We use this result to explain the tendency to better exertional performance at an increased HCT.
format	article
author	Michal Sitina Heiko Stark Stefan Schuster
author_facet	Michal Sitina Heiko Stark Stefan Schuster
author_sort	Michal Sitina
title	Calculating the optimal hematocrit under the constraint of constant cardiac power
title_short	Calculating the optimal hematocrit under the constraint of constant cardiac power
title_full	Calculating the optimal hematocrit under the constraint of constant cardiac power
title_fullStr	Calculating the optimal hematocrit under the constraint of constant cardiac power
title_full_unstemmed	Calculating the optimal hematocrit under the constraint of constant cardiac power
title_sort	calculating the optimal hematocrit under the constraint of constant cardiac power
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1113dc41d63644ffba1af1d719fd554d
work_keys_str_mv	AT michalsitina calculatingtheoptimalhematocritundertheconstraintofconstantcardiacpower AT heikostark calculatingtheoptimalhematocritundertheconstraintofconstantcardiacpower AT stefanschuster calculatingtheoptimalhematocritundertheconstraintofconstantcardiacpower
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Calculating the optimal hematocrit under the constraint of constant cardiac power

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