A mitochondrial megachannel resides in monomeric F1FO ATP synthase

The ATP synthase has been suggested to contain the mitochondrial permeability transition pore (mPTP), which has a crucial role in cell death. Here the authors show that reconstituted ATP synthase monomers form voltage-gated and Ca2+ -activated channels with the key features of mPTP.

Guardado en:

Detalles Bibliográficos
Autores principales:	Nelli Mnatsakanyan, Marc C. Llaguno, Youshan Yang, Yangyang Yan, Joachim Weber, Fred J. Sigworth, Elizabeth A. Jonas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1114e6356c4045608f3cc3526a4d63ca
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1114e6356c4045608f3cc3526a4d63ca
record_format	dspace
spelling	oai:doaj.org-article:1114e6356c4045608f3cc3526a4d63ca2021-12-02T16:58:07ZA mitochondrial megachannel resides in monomeric F1FO ATP synthase10.1038/s41467-019-13766-22041-1723https://doaj.org/article/1114e6356c4045608f3cc3526a4d63ca2019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13766-2https://doaj.org/toc/2041-1723The ATP synthase has been suggested to contain the mitochondrial permeability transition pore (mPTP), which has a crucial role in cell death. Here the authors show that reconstituted ATP synthase monomers form voltage-gated and Ca2+ -activated channels with the key features of mPTP.Nelli MnatsakanyanMarc C. LlagunoYoushan YangYangyang YanJoachim WeberFred J. SigworthElizabeth A. JonasNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nelli Mnatsakanyan Marc C. Llaguno Youshan Yang Yangyang Yan Joachim Weber Fred J. Sigworth Elizabeth A. Jonas A mitochondrial megachannel resides in monomeric F1FO ATP synthase
description	The ATP synthase has been suggested to contain the mitochondrial permeability transition pore (mPTP), which has a crucial role in cell death. Here the authors show that reconstituted ATP synthase monomers form voltage-gated and Ca2+ -activated channels with the key features of mPTP.
format	article
author	Nelli Mnatsakanyan Marc C. Llaguno Youshan Yang Yangyang Yan Joachim Weber Fred J. Sigworth Elizabeth A. Jonas
author_facet	Nelli Mnatsakanyan Marc C. Llaguno Youshan Yang Yangyang Yan Joachim Weber Fred J. Sigworth Elizabeth A. Jonas
author_sort	Nelli Mnatsakanyan
title	A mitochondrial megachannel resides in monomeric F1FO ATP synthase
title_short	A mitochondrial megachannel resides in monomeric F1FO ATP synthase
title_full	A mitochondrial megachannel resides in monomeric F1FO ATP synthase
title_fullStr	A mitochondrial megachannel resides in monomeric F1FO ATP synthase
title_full_unstemmed	A mitochondrial megachannel resides in monomeric F1FO ATP synthase
title_sort	mitochondrial megachannel resides in monomeric f1fo atp synthase
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/1114e6356c4045608f3cc3526a4d63ca
work_keys_str_mv	AT nellimnatsakanyan amitochondrialmegachannelresidesinmonomericf1foatpsynthase AT marccllaguno amitochondrialmegachannelresidesinmonomericf1foatpsynthase AT youshanyang amitochondrialmegachannelresidesinmonomericf1foatpsynthase AT yangyangyan amitochondrialmegachannelresidesinmonomericf1foatpsynthase AT joachimweber amitochondrialmegachannelresidesinmonomericf1foatpsynthase AT fredjsigworth amitochondrialmegachannelresidesinmonomericf1foatpsynthase AT elizabethajonas amitochondrialmegachannelresidesinmonomericf1foatpsynthase AT nellimnatsakanyan mitochondrialmegachannelresidesinmonomericf1foatpsynthase AT marccllaguno mitochondrialmegachannelresidesinmonomericf1foatpsynthase AT youshanyang mitochondrialmegachannelresidesinmonomericf1foatpsynthase AT yangyangyan mitochondrialmegachannelresidesinmonomericf1foatpsynthase AT joachimweber mitochondrialmegachannelresidesinmonomericf1foatpsynthase AT fredjsigworth mitochondrialmegachannelresidesinmonomericf1foatpsynthase AT elizabethajonas mitochondrialmegachannelresidesinmonomericf1foatpsynthase
_version_	1718382370757804032

A mitochondrial megachannel resides in monomeric F1FO ATP synthase

Ejemplares similares