A mitochondrial megachannel resides in monomeric F1FO ATP synthase

A mitochondrial megachannel resides in monomeric F1FO ATP synthase

The ATP synthase has been suggested to contain the mitochondrial permeability transition pore (mPTP), which has a crucial role in cell death. Here the authors show that reconstituted ATP synthase monomers form voltage-gated and Ca2+ -activated channels with the key features of mPTP.

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Detalles Bibliográficos
Autores principales: Nelli Mnatsakanyan, Marc C. Llaguno, Youshan Yang, Yangyang Yan, Joachim Weber, Fred J. Sigworth, Elizabeth A. Jonas
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/1114e6356c4045608f3cc3526a4d63ca
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