Blood-Brain Barrier Disruption by Lipopolysaccharide and Sepsis-Associated Encephalopathy

As a complex multicellular structure of the vascular system at the central nervous system (CNS), the blood-brain barrier (BBB) separates the CNS from the system circulation and regulates the influx and efflux of substances to maintain the steady-state environment of the CNS. Lipopolysaccharide (LPS)...

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Autores principales:	Xiaoyao Peng, Zhixuan Luo, Shuang He, Luhua Zhang, Ying Li
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	blood-brain barrier lipopolysaccharide sepsis-associated encephalopathy central nervous system inflammation oxidative stress Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/11154dca68374e908ec6e1d570fc4763
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spelling	oai:doaj.org-article:11154dca68374e908ec6e1d570fc47632021-11-04T05:06:31ZBlood-Brain Barrier Disruption by Lipopolysaccharide and Sepsis-Associated Encephalopathy2235-298810.3389/fcimb.2021.768108https://doaj.org/article/11154dca68374e908ec6e1d570fc47632021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcimb.2021.768108/fullhttps://doaj.org/toc/2235-2988As a complex multicellular structure of the vascular system at the central nervous system (CNS), the blood-brain barrier (BBB) separates the CNS from the system circulation and regulates the influx and efflux of substances to maintain the steady-state environment of the CNS. Lipopolysaccharide (LPS), the cell wall component of Gram-negative bacteria, can damage the barrier function of BBB and further promote the occurrence and development of sepsis-associated encephalopathy (SAE). Here, we conduct a literature review of the direct and indirect damage mechanisms of LPS to BBB and the relationship between these processes and SAE. We believe that after LPS destroys BBB, a large number of inflammatory factors and neurotoxins will enter and damage the brain tissue, which will activate brain immune cells to mediate inflammatory response and in turn further destroys BBB. This vicious circle will ultimately lead to the progression of SAE. Finally, we present a succinct overview of the treatment of SAE by restoring the BBB barrier function and summarize novel opportunities in controlling the progression of SAE by targeting the BBB.Xiaoyao PengZhixuan LuoShuang HeLuhua ZhangYing LiFrontiers Media S.A.articleblood-brain barrierlipopolysaccharidesepsis-associated encephalopathycentral nervous systeminflammationoxidative stressMicrobiologyQR1-502ENFrontiers in Cellular and Infection Microbiology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	blood-brain barrier lipopolysaccharide sepsis-associated encephalopathy central nervous system inflammation oxidative stress Microbiology QR1-502
spellingShingle	blood-brain barrier lipopolysaccharide sepsis-associated encephalopathy central nervous system inflammation oxidative stress Microbiology QR1-502 Xiaoyao Peng Zhixuan Luo Shuang He Luhua Zhang Ying Li Blood-Brain Barrier Disruption by Lipopolysaccharide and Sepsis-Associated Encephalopathy
description	As a complex multicellular structure of the vascular system at the central nervous system (CNS), the blood-brain barrier (BBB) separates the CNS from the system circulation and regulates the influx and efflux of substances to maintain the steady-state environment of the CNS. Lipopolysaccharide (LPS), the cell wall component of Gram-negative bacteria, can damage the barrier function of BBB and further promote the occurrence and development of sepsis-associated encephalopathy (SAE). Here, we conduct a literature review of the direct and indirect damage mechanisms of LPS to BBB and the relationship between these processes and SAE. We believe that after LPS destroys BBB, a large number of inflammatory factors and neurotoxins will enter and damage the brain tissue, which will activate brain immune cells to mediate inflammatory response and in turn further destroys BBB. This vicious circle will ultimately lead to the progression of SAE. Finally, we present a succinct overview of the treatment of SAE by restoring the BBB barrier function and summarize novel opportunities in controlling the progression of SAE by targeting the BBB.
format	article
author	Xiaoyao Peng Zhixuan Luo Shuang He Luhua Zhang Ying Li
author_facet	Xiaoyao Peng Zhixuan Luo Shuang He Luhua Zhang Ying Li
author_sort	Xiaoyao Peng
title	Blood-Brain Barrier Disruption by Lipopolysaccharide and Sepsis-Associated Encephalopathy
title_short	Blood-Brain Barrier Disruption by Lipopolysaccharide and Sepsis-Associated Encephalopathy
title_full	Blood-Brain Barrier Disruption by Lipopolysaccharide and Sepsis-Associated Encephalopathy
title_fullStr	Blood-Brain Barrier Disruption by Lipopolysaccharide and Sepsis-Associated Encephalopathy
title_full_unstemmed	Blood-Brain Barrier Disruption by Lipopolysaccharide and Sepsis-Associated Encephalopathy
title_sort	blood-brain barrier disruption by lipopolysaccharide and sepsis-associated encephalopathy
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/11154dca68374e908ec6e1d570fc4763
work_keys_str_mv	AT xiaoyaopeng bloodbrainbarrierdisruptionbylipopolysaccharideandsepsisassociatedencephalopathy AT zhixuanluo bloodbrainbarrierdisruptionbylipopolysaccharideandsepsisassociatedencephalopathy AT shuanghe bloodbrainbarrierdisruptionbylipopolysaccharideandsepsisassociatedencephalopathy AT luhuazhang bloodbrainbarrierdisruptionbylipopolysaccharideandsepsisassociatedencephalopathy AT yingli bloodbrainbarrierdisruptionbylipopolysaccharideandsepsisassociatedencephalopathy
_version_	1718445192730640384

Blood-Brain Barrier Disruption by Lipopolysaccharide and Sepsis-Associated Encephalopathy

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