HLA-haplotypes, anti- beta-cell antibodies: their role in prognostication of type 1 diabetes mellitus (results of 11-year observation)

The risk of type 1 diabetes mellitus (DM1) depends in the first place on the presence of predetermining HLA DR haplotypes, DQ genes, and specific autoantibodies.Aim. Prospective observation of DM1 risk groups (healthy sibs of DM patients) for the elucidation of the role of genetic and autoimmune ab...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Elena Vital'evna Titovich, Tamara Leonidovna Kuraeva, Sergey Alexandrovich Prokof'ev, Valentina Alexandrovna Peterkova, Ivan Ivanovich Dedov
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2010
Materias:	diabetes mellitus hla-haplotypes autoantibodies prognostication Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/111563def0214c30bc2c7f7b5610a3d7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:111563def0214c30bc2c7f7b5610a3d7
record_format	dspace
spelling	oai:doaj.org-article:111563def0214c30bc2c7f7b5610a3d72021-11-14T09:00:15ZHLA-haplotypes, anti- beta-cell antibodies: their role in prognostication of type 1 diabetes mellitus (results of 11-year observation)2072-03512072-037810.14341/2072-0351-6051https://doaj.org/article/111563def0214c30bc2c7f7b5610a3d72010-12-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/6051https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378The risk of type 1 diabetes mellitus (DM1) depends in the first place on the presence of predetermining HLA DR haplotypes, DQ genes, and specific autoantibodies.Aim. Prospective observation of DM1 risk groups (healthy sibs of DM patients) for the elucidation of the role of genetic and autoimmune abnormalities in thedevelopment of DM1. Materials and methods. Predetermining and protective haplotypes (HLA-DRBI, DQ genes) in combination with immunological markers (autoantibodiesto cytoplasmic structures of betbeta-cells (ICA), anti-insulin autoantibodies (IAA), anti-glutamate decarboxylase autoantibodies (GAD)) were studied in healthysibs of mean age 11.9?5.8 years selected from 143 discordant families of patients with DM1. In addition, a random sample of 599 DM1 patients (mean age7.5?6.2 years) was enrolled for molecular genetic studies (HLA-DRBI-DG genes). The control group comprised 200 subjects. Results. DQAI0501-DQB1+0201 (DQ2) and DQAI0301-DQBI*0302 (DG8) haplotype heterozygosity creating the highest risk of DM1, the healthy sibswere divided into 3 risk groups. The high risk group 1 (DQ2/DQ8) included 23 (13.5%) subjects, moderate risk group 2 (DQ2/X, DQ8/X) 85 (59.7%), andlow risk group 3 (X/X; X - any haplotype besides DQ2, DQ8) 63 (36.8%). The frequency of autoantibodies (AB) of 2 or 3 species in group 1 was higher thanin groups 2 and 3 (26.1, 14.1, 11.1% respectively, p>0.05; 8.7, 2.4, 0%, pElena Vital'evna TitovichTamara Leonidovna KuraevaSergey Alexandrovich Prokof'evValentina Alexandrovna PeterkovaIvan Ivanovich DedovEndocrinology Research Centrearticlediabetes mellitushla-haplotypesautoantibodiesprognosticationNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 13, Iss 4, Pp 12-17 (2010)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	diabetes mellitus hla-haplotypes autoantibodies prognostication Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	diabetes mellitus hla-haplotypes autoantibodies prognostication Nutritional diseases. Deficiency diseases RC620-627 Elena Vital'evna Titovich Tamara Leonidovna Kuraeva Sergey Alexandrovich Prokof'ev Valentina Alexandrovna Peterkova Ivan Ivanovich Dedov HLA-haplotypes, anti- beta-cell antibodies: their role in prognostication of type 1 diabetes mellitus (results of 11-year observation)
description	The risk of type 1 diabetes mellitus (DM1) depends in the first place on the presence of predetermining HLA DR haplotypes, DQ genes, and specific autoantibodies.Aim. Prospective observation of DM1 risk groups (healthy sibs of DM patients) for the elucidation of the role of genetic and autoimmune abnormalities in thedevelopment of DM1. Materials and methods. Predetermining and protective haplotypes (HLA-DRBI, DQ genes) in combination with immunological markers (autoantibodiesto cytoplasmic structures of betbeta-cells (ICA), anti-insulin autoantibodies (IAA), anti-glutamate decarboxylase autoantibodies (GAD)) were studied in healthysibs of mean age 11.9?5.8 years selected from 143 discordant families of patients with DM1. In addition, a random sample of 599 DM1 patients (mean age7.5?6.2 years) was enrolled for molecular genetic studies (HLA-DRBI-DG genes). The control group comprised 200 subjects. Results. DQAI0501-DQB1+0201 (DQ2) and DQAI0301-DQBI*0302 (DG8) haplotype heterozygosity creating the highest risk of DM1, the healthy sibswere divided into 3 risk groups. The high risk group 1 (DQ2/DQ8) included 23 (13.5%) subjects, moderate risk group 2 (DQ2/X, DQ8/X) 85 (59.7%), andlow risk group 3 (X/X; X - any haplotype besides DQ2, DQ8) 63 (36.8%). The frequency of autoantibodies (AB) of 2 or 3 species in group 1 was higher thanin groups 2 and 3 (26.1, 14.1, 11.1% respectively, p>0.05; 8.7, 2.4, 0%, p
format	article
author	Elena Vital'evna Titovich Tamara Leonidovna Kuraeva Sergey Alexandrovich Prokof'ev Valentina Alexandrovna Peterkova Ivan Ivanovich Dedov
author_facet	Elena Vital'evna Titovich Tamara Leonidovna Kuraeva Sergey Alexandrovich Prokof'ev Valentina Alexandrovna Peterkova Ivan Ivanovich Dedov
author_sort	Elena Vital'evna Titovich
title	HLA-haplotypes, anti- beta-cell antibodies: their role in prognostication of type 1 diabetes mellitus (results of 11-year observation)
title_short	HLA-haplotypes, anti- beta-cell antibodies: their role in prognostication of type 1 diabetes mellitus (results of 11-year observation)
title_full	HLA-haplotypes, anti- beta-cell antibodies: their role in prognostication of type 1 diabetes mellitus (results of 11-year observation)
title_fullStr	HLA-haplotypes, anti- beta-cell antibodies: their role in prognostication of type 1 diabetes mellitus (results of 11-year observation)
title_full_unstemmed	HLA-haplotypes, anti- beta-cell antibodies: their role in prognostication of type 1 diabetes mellitus (results of 11-year observation)
title_sort	hla-haplotypes, anti- beta-cell antibodies: their role in prognostication of type 1 diabetes mellitus (results of 11-year observation)
publisher	Endocrinology Research Centre
publishDate	2010
url	https://doaj.org/article/111563def0214c30bc2c7f7b5610a3d7
work_keys_str_mv	AT elenavitalevnatitovich hlahaplotypesantibetacellantibodiestheirroleinprognosticationoftype1diabetesmellitusresultsof11yearobservation AT tamaraleonidovnakuraeva hlahaplotypesantibetacellantibodiestheirroleinprognosticationoftype1diabetesmellitusresultsof11yearobservation AT sergeyalexandrovichprokofev hlahaplotypesantibetacellantibodiestheirroleinprognosticationoftype1diabetesmellitusresultsof11yearobservation AT valentinaalexandrovnapeterkova hlahaplotypesantibetacellantibodiestheirroleinprognosticationoftype1diabetesmellitusresultsof11yearobservation AT ivanivanovichdedov hlahaplotypesantibetacellantibodiestheirroleinprognosticationoftype1diabetesmellitusresultsof11yearobservation
_version_	1718429632880967680

HLA-haplotypes, anti- beta-cell antibodies: their role in prognostication of type 1 diabetes mellitus (results of 11-year observation)

Ejemplares similares