Relationship between immunological alterations, hypoxia and inflammation in arterial hypertension combined with metabolic syndrome

Our study was aimed at assessing a relationship between immune system alterations, hypoxia and inflammation in arterial hypertension (AH) coupled to metabolic disturbances. A total of 117 patients were enrolled into clinical study, having been randomized into groups in accordance with study protocol...

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Autores principales:	E. I. Polozova, E. V. Puzanova, A. A. Seskina
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2020
Materias:	arterial hypertension metabolic syndrome pathogenesis cytokine imbalance hypoxia non-specific inflammation cardiovascular events Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/1117db8095a84521aa45a25387e9c1a1
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spelling	oai:doaj.org-article:1117db8095a84521aa45a25387e9c1a12021-11-18T08:03:50ZRelationship between immunological alterations, hypoxia and inflammation in arterial hypertension combined with metabolic syndrome1563-06252313-741X10.15789/1563-0625-RBI-2059https://doaj.org/article/1117db8095a84521aa45a25387e9c1a12020-12-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/2059https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XOur study was aimed at assessing a relationship between immune system alterations, hypoxia and inflammation in arterial hypertension (AH) coupled to metabolic disturbances. A total of 117 patients were enrolled into clinical study, having been randomized into groups in accordance with study protocol, aged 30 to 62 years. They sought care in outpatient setting or underwent periodic health examination at the Republican Clinical Hospital №5, Saransk, Mordovia, Russia. A control group contained 25 apparently healthy subjects lacking signs of metabolic syndrome (MS) and elevated arterial pressure. A comparison group contained 47 patients with AH grade I-II featured with damaged target organs, but lacking associated relevant clinical manifestations, as based on the assay data. The main group contained 45 patients receiving antihypertensive therapy with overt AH grade I-II verified upon medical consultation coupled to damaged target organs and MS signs with its randomly combined components, but lacking associated clinical manifestations. The patients from main and comparison groups received antihypertensive therapy in accordance with approved guidelines and clinical recommendations for management of AH patients consisting of one of renin-angiotensin-aldosterone system blockers, diuretic and/or dihydropyridine calcium channel blocker. Cytokine profile, level of hypoxia and non-specific inflammation were measured in blood serum. The data obtained demonstrated that AH patients with/without metabolic syndrome were noted to display cytokine profile shifted towards elevated proand anti-inflammatory immune arm pointing at imbalanced immune regulation. Hypoxic changes were also found in blood serum that was confirmed by elevated level of lactic and pyruvic acid in these groups. Moreover, development of such pathology was coupled to hypoxia which served as a modulator of immune-related and non-specific inflammation. Rise of non-specific low-grade inflammation correlates developing irreversible AH-associated changes in organs, progression of atherosclerosis and accelerated cardio-metabolic continuum. Altogether, such alterations underlie pathogenetic mechanisms of tissue damage emerging upon AH and MS being mutually aggravating factor along with activated renin-angiotensin-aldosterone system.E. I. PolozovaE. V. PuzanovaA. A. SeskinaSPb RAACIarticlearterial hypertensionmetabolic syndromepathogenesiscytokine imbalancehypoxianon-specific inflammationcardiovascular eventsImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 22, Iss 5, Pp 1003-1008 (2020)
institution	DOAJ
collection	DOAJ
language	RU
topic	arterial hypertension metabolic syndrome pathogenesis cytokine imbalance hypoxia non-specific inflammation cardiovascular events Immunologic diseases. Allergy RC581-607
spellingShingle	arterial hypertension metabolic syndrome pathogenesis cytokine imbalance hypoxia non-specific inflammation cardiovascular events Immunologic diseases. Allergy RC581-607 E. I. Polozova E. V. Puzanova A. A. Seskina Relationship between immunological alterations, hypoxia and inflammation in arterial hypertension combined with metabolic syndrome
description	Our study was aimed at assessing a relationship between immune system alterations, hypoxia and inflammation in arterial hypertension (AH) coupled to metabolic disturbances. A total of 117 patients were enrolled into clinical study, having been randomized into groups in accordance with study protocol, aged 30 to 62 years. They sought care in outpatient setting or underwent periodic health examination at the Republican Clinical Hospital №5, Saransk, Mordovia, Russia. A control group contained 25 apparently healthy subjects lacking signs of metabolic syndrome (MS) and elevated arterial pressure. A comparison group contained 47 patients with AH grade I-II featured with damaged target organs, but lacking associated relevant clinical manifestations, as based on the assay data. The main group contained 45 patients receiving antihypertensive therapy with overt AH grade I-II verified upon medical consultation coupled to damaged target organs and MS signs with its randomly combined components, but lacking associated clinical manifestations. The patients from main and comparison groups received antihypertensive therapy in accordance with approved guidelines and clinical recommendations for management of AH patients consisting of one of renin-angiotensin-aldosterone system blockers, diuretic and/or dihydropyridine calcium channel blocker. Cytokine profile, level of hypoxia and non-specific inflammation were measured in blood serum. The data obtained demonstrated that AH patients with/without metabolic syndrome were noted to display cytokine profile shifted towards elevated proand anti-inflammatory immune arm pointing at imbalanced immune regulation. Hypoxic changes were also found in blood serum that was confirmed by elevated level of lactic and pyruvic acid in these groups. Moreover, development of such pathology was coupled to hypoxia which served as a modulator of immune-related and non-specific inflammation. Rise of non-specific low-grade inflammation correlates developing irreversible AH-associated changes in organs, progression of atherosclerosis and accelerated cardio-metabolic continuum. Altogether, such alterations underlie pathogenetic mechanisms of tissue damage emerging upon AH and MS being mutually aggravating factor along with activated renin-angiotensin-aldosterone system.
format	article
author	E. I. Polozova E. V. Puzanova A. A. Seskina
author_facet	E. I. Polozova E. V. Puzanova A. A. Seskina
author_sort	E. I. Polozova
title	Relationship between immunological alterations, hypoxia and inflammation in arterial hypertension combined with metabolic syndrome
title_short	Relationship between immunological alterations, hypoxia and inflammation in arterial hypertension combined with metabolic syndrome
title_full	Relationship between immunological alterations, hypoxia and inflammation in arterial hypertension combined with metabolic syndrome
title_fullStr	Relationship between immunological alterations, hypoxia and inflammation in arterial hypertension combined with metabolic syndrome
title_full_unstemmed	Relationship between immunological alterations, hypoxia and inflammation in arterial hypertension combined with metabolic syndrome
title_sort	relationship between immunological alterations, hypoxia and inflammation in arterial hypertension combined with metabolic syndrome
publisher	SPb RAACI
publishDate	2020
url	https://doaj.org/article/1117db8095a84521aa45a25387e9c1a1
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_version_	1718422272880934912

Relationship between immunological alterations, hypoxia and inflammation in arterial hypertension combined with metabolic syndrome

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