Systemic short chain fatty acids limit antitumor effect of CTLA-4 blockade in hosts with cancer

The gut microbiota has been reported to regulate the efficacy of cancer therapy. Here, the authors show that short-chain fatty acids, which are generated through bacterial fermentation, increases immune tolerance leading to resistance to anti-CTLA-4 immunotherapy in mice and patients with metastatic...

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Autores principales:	Clélia Coutzac, Jean-Mehdi Jouniaux, Angelo Paci, Julien Schmidt, Domenico Mallardo, Atmane Seck, Vahe Asvatourian, Lydie Cassard, Patrick Saulnier, Ludovic Lacroix, Paul-Louis Woerther, Aurore Vozy, Marie Naigeon, Laetitia Nebot-Bral, Mélanie Desbois, Ester Simeone, Christine Mateus, Lisa Boselli, Jonathan Grivel, Emilie Soularue, Patricia Lepage, Franck Carbonnel, Paolo Antonio Ascierto, Caroline Robert, Nathalie Chaput
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1117fcdf2fd44e30b8bbaa1e829d3ecf
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spelling	oai:doaj.org-article:1117fcdf2fd44e30b8bbaa1e829d3ecf2021-12-02T16:49:59ZSystemic short chain fatty acids limit antitumor effect of CTLA-4 blockade in hosts with cancer10.1038/s41467-020-16079-x2041-1723https://doaj.org/article/1117fcdf2fd44e30b8bbaa1e829d3ecf2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16079-xhttps://doaj.org/toc/2041-1723The gut microbiota has been reported to regulate the efficacy of cancer therapy. Here, the authors show that short-chain fatty acids, which are generated through bacterial fermentation, increases immune tolerance leading to resistance to anti-CTLA-4 immunotherapy in mice and patients with metastatic melanoma.Clélia CoutzacJean-Mehdi JouniauxAngelo PaciJulien SchmidtDomenico MallardoAtmane SeckVahe AsvatourianLydie CassardPatrick SaulnierLudovic LacroixPaul-Louis WoertherAurore VozyMarie NaigeonLaetitia Nebot-BralMélanie DesboisEster SimeoneChristine MateusLisa BoselliJonathan GrivelEmilie SoularuePatricia LepageFranck CarbonnelPaolo Antonio AsciertoCaroline RobertNathalie ChaputNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Clélia Coutzac Jean-Mehdi Jouniaux Angelo Paci Julien Schmidt Domenico Mallardo Atmane Seck Vahe Asvatourian Lydie Cassard Patrick Saulnier Ludovic Lacroix Paul-Louis Woerther Aurore Vozy Marie Naigeon Laetitia Nebot-Bral Mélanie Desbois Ester Simeone Christine Mateus Lisa Boselli Jonathan Grivel Emilie Soularue Patricia Lepage Franck Carbonnel Paolo Antonio Ascierto Caroline Robert Nathalie Chaput Systemic short chain fatty acids limit antitumor effect of CTLA-4 blockade in hosts with cancer
description	The gut microbiota has been reported to regulate the efficacy of cancer therapy. Here, the authors show that short-chain fatty acids, which are generated through bacterial fermentation, increases immune tolerance leading to resistance to anti-CTLA-4 immunotherapy in mice and patients with metastatic melanoma.
format	article
author	Clélia Coutzac Jean-Mehdi Jouniaux Angelo Paci Julien Schmidt Domenico Mallardo Atmane Seck Vahe Asvatourian Lydie Cassard Patrick Saulnier Ludovic Lacroix Paul-Louis Woerther Aurore Vozy Marie Naigeon Laetitia Nebot-Bral Mélanie Desbois Ester Simeone Christine Mateus Lisa Boselli Jonathan Grivel Emilie Soularue Patricia Lepage Franck Carbonnel Paolo Antonio Ascierto Caroline Robert Nathalie Chaput
author_facet	Clélia Coutzac Jean-Mehdi Jouniaux Angelo Paci Julien Schmidt Domenico Mallardo Atmane Seck Vahe Asvatourian Lydie Cassard Patrick Saulnier Ludovic Lacroix Paul-Louis Woerther Aurore Vozy Marie Naigeon Laetitia Nebot-Bral Mélanie Desbois Ester Simeone Christine Mateus Lisa Boselli Jonathan Grivel Emilie Soularue Patricia Lepage Franck Carbonnel Paolo Antonio Ascierto Caroline Robert Nathalie Chaput
author_sort	Clélia Coutzac
title	Systemic short chain fatty acids limit antitumor effect of CTLA-4 blockade in hosts with cancer
title_short	Systemic short chain fatty acids limit antitumor effect of CTLA-4 blockade in hosts with cancer
title_full	Systemic short chain fatty acids limit antitumor effect of CTLA-4 blockade in hosts with cancer
title_fullStr	Systemic short chain fatty acids limit antitumor effect of CTLA-4 blockade in hosts with cancer
title_full_unstemmed	Systemic short chain fatty acids limit antitumor effect of CTLA-4 blockade in hosts with cancer
title_sort	systemic short chain fatty acids limit antitumor effect of ctla-4 blockade in hosts with cancer
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/1117fcdf2fd44e30b8bbaa1e829d3ecf
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Systemic short chain fatty acids limit antitumor effect of CTLA-4 blockade in hosts with cancer

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