Systemic short chain fatty acids limit antitumor effect of CTLA-4 blockade in hosts with cancer
The gut microbiota has been reported to regulate the efficacy of cancer therapy. Here, the authors show that short-chain fatty acids, which are generated through bacterial fermentation, increases immune tolerance leading to resistance to anti-CTLA-4 immunotherapy in mice and patients with metastatic...
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | article |
| Language: | EN |
| Published: |
Nature Portfolio
2020
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| Subjects: | |
| Online Access: | https://doaj.org/article/1117fcdf2fd44e30b8bbaa1e829d3ecf |
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