Iron status and the acute post-exercise hepcidin response in athletes.

This study explored the relationship between serum ferritin and hepcidin in athletes. Baseline serum ferritin levels of 54 athletes from the control trial of five investigations conducted in our laboratory were considered; athletes were grouped according to values <30 μg/L (SF<30), 30-50 μg/L...

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Autores principales:	Peter Peeling, Marc Sim, Claire E Badenhorst, Brian Dawson, Andrew D Govus, Chris R Abbiss, Dorine W Swinkels, Debbie Trinder
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/111803da2dd843328ab863bd6cbb514d
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spelling	oai:doaj.org-article:111803da2dd843328ab863bd6cbb514d2021-11-18T08:26:21ZIron status and the acute post-exercise hepcidin response in athletes.1932-620310.1371/journal.pone.0093002https://doaj.org/article/111803da2dd843328ab863bd6cbb514d2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24667393/?tool=EBIhttps://doaj.org/toc/1932-6203This study explored the relationship between serum ferritin and hepcidin in athletes. Baseline serum ferritin levels of 54 athletes from the control trial of five investigations conducted in our laboratory were considered; athletes were grouped according to values <30 μg/L (SF<30), 30-50 μg/L (SF30-50), 50-100 μg/L (SF50-100), or >100 μg/L (SF>100). Data pooling resulted in each athlete completing one of five running sessions: (1) 8 × 3 min at 85% vVO2peak; (2) 5 × 4 min at 90% vVO2peak; (3) 90 min continuous at 75% vVO2peak; (4) 40 min continuous at 75% vVO2peak; (5) 40 min continuous at 65% vVO2peak. Athletes from each running session were represented amongst all four groups; hence, the mean exercise duration and intensity were not different (p>0.05). Venous blood samples were collected pre-, post- and 3 h post-exercise, and were analysed for serum ferritin, iron, interleukin-6 (IL-6) and hepcidin-25. Baseline and post-exercise serum ferritin levels were different between groups (p<0.05). There were no group differences for pre- or post-exercise serum iron or IL-6 (p>0.05). Post-exercise IL-6 was significantly elevated compared to baseline within each group (p<0.05). Pre- and 3 h post-exercise hepcidin-25 was sequentially greater as the groups baseline serum ferritin levels increased (p<0.05). However, post-exercise hepcidin levels were only significantly elevated in three groups (SF30-50, SF50-100, and SF>100; p<0.05). An athlete's iron stores may dictate the baseline hepcidin levels and the magnitude of post-exercise hepcidin response. Low iron stores suppressed post-exercise hepcidin, seemingly overriding any inflammatory-driven increases.Peter PeelingMarc SimClaire E BadenhorstBrian DawsonAndrew D GovusChris R AbbissDorine W SwinkelsDebbie TrinderPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 3, p e93002 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Peter Peeling Marc Sim Claire E Badenhorst Brian Dawson Andrew D Govus Chris R Abbiss Dorine W Swinkels Debbie Trinder Iron status and the acute post-exercise hepcidin response in athletes.
description	This study explored the relationship between serum ferritin and hepcidin in athletes. Baseline serum ferritin levels of 54 athletes from the control trial of five investigations conducted in our laboratory were considered; athletes were grouped according to values <30 μg/L (SF<30), 30-50 μg/L (SF30-50), 50-100 μg/L (SF50-100), or >100 μg/L (SF>100). Data pooling resulted in each athlete completing one of five running sessions: (1) 8 × 3 min at 85% vVO2peak; (2) 5 × 4 min at 90% vVO2peak; (3) 90 min continuous at 75% vVO2peak; (4) 40 min continuous at 75% vVO2peak; (5) 40 min continuous at 65% vVO2peak. Athletes from each running session were represented amongst all four groups; hence, the mean exercise duration and intensity were not different (p>0.05). Venous blood samples were collected pre-, post- and 3 h post-exercise, and were analysed for serum ferritin, iron, interleukin-6 (IL-6) and hepcidin-25. Baseline and post-exercise serum ferritin levels were different between groups (p<0.05). There were no group differences for pre- or post-exercise serum iron or IL-6 (p>0.05). Post-exercise IL-6 was significantly elevated compared to baseline within each group (p<0.05). Pre- and 3 h post-exercise hepcidin-25 was sequentially greater as the groups baseline serum ferritin levels increased (p<0.05). However, post-exercise hepcidin levels were only significantly elevated in three groups (SF30-50, SF50-100, and SF>100; p<0.05). An athlete's iron stores may dictate the baseline hepcidin levels and the magnitude of post-exercise hepcidin response. Low iron stores suppressed post-exercise hepcidin, seemingly overriding any inflammatory-driven increases.
format	article
author	Peter Peeling Marc Sim Claire E Badenhorst Brian Dawson Andrew D Govus Chris R Abbiss Dorine W Swinkels Debbie Trinder
author_facet	Peter Peeling Marc Sim Claire E Badenhorst Brian Dawson Andrew D Govus Chris R Abbiss Dorine W Swinkels Debbie Trinder
author_sort	Peter Peeling
title	Iron status and the acute post-exercise hepcidin response in athletes.
title_short	Iron status and the acute post-exercise hepcidin response in athletes.
title_full	Iron status and the acute post-exercise hepcidin response in athletes.
title_fullStr	Iron status and the acute post-exercise hepcidin response in athletes.
title_full_unstemmed	Iron status and the acute post-exercise hepcidin response in athletes.
title_sort	iron status and the acute post-exercise hepcidin response in athletes.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/111803da2dd843328ab863bd6cbb514d
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Iron status and the acute post-exercise hepcidin response in athletes.

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