Interactive Effect of IGF2BP2 rs4402960 Variant, Smoking and Type 2 Diabetes

Oswald Ndi Nfor,1 Nokuphila Balindile Ndzinisa,1 Meng‑Hsiun Tsai,2 Chih-Hsuan Hsiao,1 Yung-Po Liaw1,3 1Department of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung City 40201, Taiwan; 2Department of Management Information Systems, National Chung Hsing Universit...

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Autores principales:	Nfor ON, Ndzinisa NB, Tsai MH, Hsiao CH, Liaw YP
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	polymorphism metabolic syndrome lifestyle diabetes Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/11199e9f0f5a44049fd4c8543cd04f8d
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spelling	oai:doaj.org-article:11199e9f0f5a44049fd4c8543cd04f8d2021-12-02T15:06:10ZInteractive Effect of IGF2BP2 rs4402960 Variant, Smoking and Type 2 Diabetes1178-7007https://doaj.org/article/11199e9f0f5a44049fd4c8543cd04f8d2020-12-01T00:00:00Zhttps://www.dovepress.com/interactive-effect-of-igf2bp2-rs4402960-variant-smoking-and-type-2-dia-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Oswald Ndi Nfor,1 Nokuphila Balindile Ndzinisa,1 Meng‑Hsiun Tsai,2 Chih-Hsuan Hsiao,1 Yung-Po Liaw1,3 1Department of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung City 40201, Taiwan; 2Department of Management Information Systems, National Chung Hsing University, Taichung, Taiwan; 3Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung City 40201, TaiwanCorrespondence: Yung-Po LiawDepartment of Public Health and Institute of Public Health, Chung Shan Medical University, No. 110, Sec. 1 Jianguo N. Road, Taichung City 40201, TaiwanTel +886-4-24730022 ext.11838Fax +886-4-23248179Email Liawyp@csmu.edu.twPurpose: Genetic and environmental factors are related to type 2 diabetes (T2D). Genetic modifiers of T2D have not been widely determined among smoking individuals. In this population-based study, we investigated the interactive association between rs4402960 polymorphism of the insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) gene and smoking with T2D among Taiwanese adults.Materials and Methods: We obtained genetic data collected between 2008 and 2018 for 22,039 participants (aged 30– 70 years) from the Taiwan Biobank (TWB) database. These data were analyzed using the t-test, Chi-square (χ2) test, and multiple logistic regression.Results: The mean ages for participants with and without diabetes were 58.11± 8.75 and 48.58± 11, respectively. Compared with the rs4402960 GG genotype, the odds ratio (OR) for T2D was 1.261 among GT and 1.545 among TT genotype individuals (p< 0.05). Current smokers compared to nonsmokers were associated with a higher risk of T2D (OR=1.266, p=0.0404). There was a significant interaction between the IGF2BP2 rs4402960 variant and smoking on T2D (p = 0.0497). After stratification by rs4402960 genotypes and smoking status, the OR was substantial only in current smokers with GG genotype (OR, 1.663, p = 0.0008).Conclusion: This population-based study indicated that the risk for T2D was stronger among current smoking rs4402960 GG individuals recruited between 2008 and 2019 in Taiwan.Keywords: polymorphism, metabolic syndrome, lifestyle, diabetesNfor ONNdzinisa NBTsai MHHsiao CHLiaw YPDove Medical Pressarticlepolymorphismmetabolic syndromelifestylediabetesSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 5097-5102 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	polymorphism metabolic syndrome lifestyle diabetes Specialties of internal medicine RC581-951
spellingShingle	polymorphism metabolic syndrome lifestyle diabetes Specialties of internal medicine RC581-951 Nfor ON Ndzinisa NB Tsai MH Hsiao CH Liaw YP Interactive Effect of IGF2BP2 rs4402960 Variant, Smoking and Type 2 Diabetes
description	Oswald Ndi Nfor,1 Nokuphila Balindile Ndzinisa,1 Meng‑Hsiun Tsai,2 Chih-Hsuan Hsiao,1 Yung-Po Liaw1,3 1Department of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung City 40201, Taiwan; 2Department of Management Information Systems, National Chung Hsing University, Taichung, Taiwan; 3Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung City 40201, TaiwanCorrespondence: Yung-Po LiawDepartment of Public Health and Institute of Public Health, Chung Shan Medical University, No. 110, Sec. 1 Jianguo N. Road, Taichung City 40201, TaiwanTel +886-4-24730022 ext.11838Fax +886-4-23248179Email Liawyp@csmu.edu.twPurpose: Genetic and environmental factors are related to type 2 diabetes (T2D). Genetic modifiers of T2D have not been widely determined among smoking individuals. In this population-based study, we investigated the interactive association between rs4402960 polymorphism of the insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) gene and smoking with T2D among Taiwanese adults.Materials and Methods: We obtained genetic data collected between 2008 and 2018 for 22,039 participants (aged 30– 70 years) from the Taiwan Biobank (TWB) database. These data were analyzed using the t-test, Chi-square (χ2) test, and multiple logistic regression.Results: The mean ages for participants with and without diabetes were 58.11± 8.75 and 48.58± 11, respectively. Compared with the rs4402960 GG genotype, the odds ratio (OR) for T2D was 1.261 among GT and 1.545 among TT genotype individuals (p< 0.05). Current smokers compared to nonsmokers were associated with a higher risk of T2D (OR=1.266, p=0.0404). There was a significant interaction between the IGF2BP2 rs4402960 variant and smoking on T2D (p = 0.0497). After stratification by rs4402960 genotypes and smoking status, the OR was substantial only in current smokers with GG genotype (OR, 1.663, p = 0.0008).Conclusion: This population-based study indicated that the risk for T2D was stronger among current smoking rs4402960 GG individuals recruited between 2008 and 2019 in Taiwan.Keywords: polymorphism, metabolic syndrome, lifestyle, diabetes
format	article
author	Nfor ON Ndzinisa NB Tsai MH Hsiao CH Liaw YP
author_facet	Nfor ON Ndzinisa NB Tsai MH Hsiao CH Liaw YP
author_sort	Nfor ON
title	Interactive Effect of IGF2BP2 rs4402960 Variant, Smoking and Type 2 Diabetes
title_short	Interactive Effect of IGF2BP2 rs4402960 Variant, Smoking and Type 2 Diabetes
title_full	Interactive Effect of IGF2BP2 rs4402960 Variant, Smoking and Type 2 Diabetes
title_fullStr	Interactive Effect of IGF2BP2 rs4402960 Variant, Smoking and Type 2 Diabetes
title_full_unstemmed	Interactive Effect of IGF2BP2 rs4402960 Variant, Smoking and Type 2 Diabetes
title_sort	interactive effect of igf2bp2 rs4402960 variant, smoking and type 2 diabetes
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/11199e9f0f5a44049fd4c8543cd04f8d
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Interactive Effect of IGF2BP2 rs4402960 Variant, Smoking and Type 2 Diabetes

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