Modulating the Blood–Brain Barrier: A Comprehensive Review

The highly secure blood–brain barrier (BBB) restricts drug access to the brain, limiting the molecular toolkit for treating central nervous system (CNS) diseases to small, lipophilic drugs. Development of a safe and effective BBB modulator would revolutionise the treatment of CNS diseases and future...

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Autores principales:	Rory Whelan, Grainne C. Hargaden, Andrew J. S. Knox
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	blood-brain barrier (BBB) CNS drug delivery tight junction (TJ) BBB permeability BBB modulation focused ultrasound Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/111a4f7385d448179d6db14173518d08
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spelling	oai:doaj.org-article:111a4f7385d448179d6db14173518d082021-11-25T18:42:45ZModulating the Blood–Brain Barrier: A Comprehensive Review10.3390/pharmaceutics131119801999-4923https://doaj.org/article/111a4f7385d448179d6db14173518d082021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1980https://doaj.org/toc/1999-4923The highly secure blood–brain barrier (BBB) restricts drug access to the brain, limiting the molecular toolkit for treating central nervous system (CNS) diseases to small, lipophilic drugs. Development of a safe and effective BBB modulator would revolutionise the treatment of CNS diseases and future drug development in the area. Naturally, the field has garnered a great deal of attention, leading to a vast and diverse range of BBB modulators. In this review, we summarise and compare the various classes of BBB modulators developed over the last five decades—their recent advancements, advantages and disadvantages, while providing some insight into their future as BBB modulators.Rory WhelanGrainne C. HargadenAndrew J. S. KnoxMDPI AGarticleblood-brain barrier (BBB)CNS drug deliverytight junction (TJ)BBB permeabilityBBB modulationfocused ultrasoundPharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1980, p 1980 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	blood-brain barrier (BBB) CNS drug delivery tight junction (TJ) BBB permeability BBB modulation focused ultrasound Pharmacy and materia medica RS1-441
spellingShingle	blood-brain barrier (BBB) CNS drug delivery tight junction (TJ) BBB permeability BBB modulation focused ultrasound Pharmacy and materia medica RS1-441 Rory Whelan Grainne C. Hargaden Andrew J. S. Knox Modulating the Blood–Brain Barrier: A Comprehensive Review
description	The highly secure blood–brain barrier (BBB) restricts drug access to the brain, limiting the molecular toolkit for treating central nervous system (CNS) diseases to small, lipophilic drugs. Development of a safe and effective BBB modulator would revolutionise the treatment of CNS diseases and future drug development in the area. Naturally, the field has garnered a great deal of attention, leading to a vast and diverse range of BBB modulators. In this review, we summarise and compare the various classes of BBB modulators developed over the last five decades—their recent advancements, advantages and disadvantages, while providing some insight into their future as BBB modulators.
format	article
author	Rory Whelan Grainne C. Hargaden Andrew J. S. Knox
author_facet	Rory Whelan Grainne C. Hargaden Andrew J. S. Knox
author_sort	Rory Whelan
title	Modulating the Blood–Brain Barrier: A Comprehensive Review
title_short	Modulating the Blood–Brain Barrier: A Comprehensive Review
title_full	Modulating the Blood–Brain Barrier: A Comprehensive Review
title_fullStr	Modulating the Blood–Brain Barrier: A Comprehensive Review
title_full_unstemmed	Modulating the Blood–Brain Barrier: A Comprehensive Review
title_sort	modulating the blood–brain barrier: a comprehensive review
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/111a4f7385d448179d6db14173518d08
work_keys_str_mv	AT rorywhelan modulatingthebloodbrainbarrieracomprehensivereview AT grainnechargaden modulatingthebloodbrainbarrieracomprehensivereview AT andrewjsknox modulatingthebloodbrainbarrieracomprehensivereview
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Modulating the Blood–Brain Barrier: A Comprehensive Review

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