PX-RICS-deficient mice mimic autism spectrum disorder in Jacobsen syndrome through impaired GABAA receptor trafficking

The molecular underpinning of autism is unclear. Here the authors show PX-RICS deficient mice exhibit autism-like social behavioural abnormalities and impaired GABAA receptor trafficking, and enhancing inhibitory synaptic transmission with a GABAAreceptor agonist ameliorate the behavioural deficits.

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Autores principales:	Tsutomu Nakamura, Fumiko Arima-Yoshida, Fumika Sakaue, Yukiko Nasu-Nishimura, Yasuko Takeda, Ken Matsuura, Natacha Akshoomoff, Sarah N. Mattson, Paul D. Grossfeld, Toshiya Manabe, Tetsu Akiyama
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/111e3b7f27194d44a435bfedacde52eb
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spelling	oai:doaj.org-article:111e3b7f27194d44a435bfedacde52eb2021-12-02T15:35:41ZPX-RICS-deficient mice mimic autism spectrum disorder in Jacobsen syndrome through impaired GABAA receptor trafficking10.1038/ncomms108612041-1723https://doaj.org/article/111e3b7f27194d44a435bfedacde52eb2016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10861https://doaj.org/toc/2041-1723The molecular underpinning of autism is unclear. Here the authors show PX-RICS deficient mice exhibit autism-like social behavioural abnormalities and impaired GABAA receptor trafficking, and enhancing inhibitory synaptic transmission with a GABAAreceptor agonist ameliorate the behavioural deficits.Tsutomu NakamuraFumiko Arima-YoshidaFumika SakaueYukiko Nasu-NishimuraYasuko TakedaKen MatsuuraNatacha AkshoomoffSarah N. MattsonPaul D. GrossfeldToshiya ManabeTetsu AkiyamaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tsutomu Nakamura Fumiko Arima-Yoshida Fumika Sakaue Yukiko Nasu-Nishimura Yasuko Takeda Ken Matsuura Natacha Akshoomoff Sarah N. Mattson Paul D. Grossfeld Toshiya Manabe Tetsu Akiyama PX-RICS-deficient mice mimic autism spectrum disorder in Jacobsen syndrome through impaired GABAA receptor trafficking
description	The molecular underpinning of autism is unclear. Here the authors show PX-RICS deficient mice exhibit autism-like social behavioural abnormalities and impaired GABAA receptor trafficking, and enhancing inhibitory synaptic transmission with a GABAAreceptor agonist ameliorate the behavioural deficits.
format	article
author	Tsutomu Nakamura Fumiko Arima-Yoshida Fumika Sakaue Yukiko Nasu-Nishimura Yasuko Takeda Ken Matsuura Natacha Akshoomoff Sarah N. Mattson Paul D. Grossfeld Toshiya Manabe Tetsu Akiyama
author_facet	Tsutomu Nakamura Fumiko Arima-Yoshida Fumika Sakaue Yukiko Nasu-Nishimura Yasuko Takeda Ken Matsuura Natacha Akshoomoff Sarah N. Mattson Paul D. Grossfeld Toshiya Manabe Tetsu Akiyama
author_sort	Tsutomu Nakamura
title	PX-RICS-deficient mice mimic autism spectrum disorder in Jacobsen syndrome through impaired GABAA receptor trafficking
title_short	PX-RICS-deficient mice mimic autism spectrum disorder in Jacobsen syndrome through impaired GABAA receptor trafficking
title_full	PX-RICS-deficient mice mimic autism spectrum disorder in Jacobsen syndrome through impaired GABAA receptor trafficking
title_fullStr	PX-RICS-deficient mice mimic autism spectrum disorder in Jacobsen syndrome through impaired GABAA receptor trafficking
title_full_unstemmed	PX-RICS-deficient mice mimic autism spectrum disorder in Jacobsen syndrome through impaired GABAA receptor trafficking
title_sort	px-rics-deficient mice mimic autism spectrum disorder in jacobsen syndrome through impaired gabaa receptor trafficking
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/111e3b7f27194d44a435bfedacde52eb
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PX-RICS-deficient mice mimic autism spectrum disorder in Jacobsen syndrome through impaired GABAA receptor trafficking

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