Programming living sensors for environment, health and biomanufacturing

Summary Synthetic biology offers new tools and capabilities of engineering cells with desired functions for example as new biosensing platforms leveraging engineered microbes. In the last two decades, bacterial cells have been programmed to sense and respond to various input cues for versatile purpo...

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Autores principales:	Xinyi Wan, Behide Saltepe, Luyang Yu, Baojun Wang
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/111e3e5111f94f7592048f8c1995fe6b
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spelling	oai:doaj.org-article:111e3e5111f94f7592048f8c1995fe6b2021-11-18T15:39:52ZProgramming living sensors for environment, health and biomanufacturing1751-791510.1111/1751-7915.13820https://doaj.org/article/111e3e5111f94f7592048f8c1995fe6b2021-11-01T00:00:00Zhttps://doi.org/10.1111/1751-7915.13820https://doaj.org/toc/1751-7915Summary Synthetic biology offers new tools and capabilities of engineering cells with desired functions for example as new biosensing platforms leveraging engineered microbes. In the last two decades, bacterial cells have been programmed to sense and respond to various input cues for versatile purposes including environmental monitoring, disease diagnosis and adaptive biomanufacturing. Despite demonstrated proof‐of‐concept success in the laboratory, the real‐world applications of microbial sensors have been restricted due to certain technical and societal limitations. Yet, most limitations can be addressed by new technological developments in synthetic biology such as circuit design, biocontainment and machine learning. Here, we summarize the latest advances in synthetic biology and discuss how they could accelerate the development, enhance the performance and address the present limitations of microbial sensors to facilitate their use in the field. We view that programmable living sensors are promising sensing platforms to achieve sustainable, affordable and easy‐to‐use on‐site detection in diverse settings.Xinyi WanBehide SaltepeLuyang YuBaojun WangWileyarticleBiotechnologyTP248.13-248.65ENMicrobial Biotechnology, Vol 14, Iss 6, Pp 2334-2342 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biotechnology TP248.13-248.65
spellingShingle	Biotechnology TP248.13-248.65 Xinyi Wan Behide Saltepe Luyang Yu Baojun Wang Programming living sensors for environment, health and biomanufacturing
description	Summary Synthetic biology offers new tools and capabilities of engineering cells with desired functions for example as new biosensing platforms leveraging engineered microbes. In the last two decades, bacterial cells have been programmed to sense and respond to various input cues for versatile purposes including environmental monitoring, disease diagnosis and adaptive biomanufacturing. Despite demonstrated proof‐of‐concept success in the laboratory, the real‐world applications of microbial sensors have been restricted due to certain technical and societal limitations. Yet, most limitations can be addressed by new technological developments in synthetic biology such as circuit design, biocontainment and machine learning. Here, we summarize the latest advances in synthetic biology and discuss how they could accelerate the development, enhance the performance and address the present limitations of microbial sensors to facilitate their use in the field. We view that programmable living sensors are promising sensing platforms to achieve sustainable, affordable and easy‐to‐use on‐site detection in diverse settings.
format	article
author	Xinyi Wan Behide Saltepe Luyang Yu Baojun Wang
author_facet	Xinyi Wan Behide Saltepe Luyang Yu Baojun Wang
author_sort	Xinyi Wan
title	Programming living sensors for environment, health and biomanufacturing
title_short	Programming living sensors for environment, health and biomanufacturing
title_full	Programming living sensors for environment, health and biomanufacturing
title_fullStr	Programming living sensors for environment, health and biomanufacturing
title_full_unstemmed	Programming living sensors for environment, health and biomanufacturing
title_sort	programming living sensors for environment, health and biomanufacturing
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/111e3e5111f94f7592048f8c1995fe6b
work_keys_str_mv	AT xinyiwan programminglivingsensorsforenvironmenthealthandbiomanufacturing AT behidesaltepe programminglivingsensorsforenvironmenthealthandbiomanufacturing AT luyangyu programminglivingsensorsforenvironmenthealthandbiomanufacturing AT baojunwang programminglivingsensorsforenvironmenthealthandbiomanufacturing
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Programming living sensors for environment, health and biomanufacturing

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