The prognostic role of RBP-4 and adiponectin in patients with peripheral arterial disease undergoing lower limb endovascular revascularization

Abstract Background RBP4 is an adipokine with an established role in atherosclerosis, while adiponectin has unique anti-inflammatory properties. We investigated the association of RBP4 and adiponectin with the presence of symptomatic peripheral artery disease (PAD) and their possible prognostic role...

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Autores principales:	Nikolaos P. E. Kadoglou, Emmanouil Korakas, Christos Karkos, Eirini Maratou, Ioannis Kanonidis, Panagiotis Plotas, Nikolaos Papanas, Paraskevi Moutsatsou, Ignatios Ikonomidis, Vaia Lambadiari
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	RBP4 Adiponectin Peripheral artery disease MACE Inflammation Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/11216b66928f4d9ca8345b7c32066a75
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spelling	oai:doaj.org-article:11216b66928f4d9ca8345b7c32066a752021-11-14T12:15:51ZThe prognostic role of RBP-4 and adiponectin in patients with peripheral arterial disease undergoing lower limb endovascular revascularization10.1186/s12933-021-01411-61475-2840https://doaj.org/article/11216b66928f4d9ca8345b7c32066a752021-11-01T00:00:00Zhttps://doi.org/10.1186/s12933-021-01411-6https://doaj.org/toc/1475-2840Abstract Background RBP4 is an adipokine with an established role in atherosclerosis, while adiponectin has unique anti-inflammatory properties. We investigated the association of RBP4 and adiponectin with the presence of symptomatic peripheral artery disease (PAD) and their possible prognostic role in major adverse cardiovascular events (MACE). Methods We enrolled 168 consecutive patients with symptomatic, established PAD, requiring revascularization by endovascular means of any or both of their lower limbs. 88 age- and sex-matched subjects with less than 2 classical cardiovascular risk factors served as controls. Clinical parameters, glycemic and lipid profile, RBP4 and adiponectin levels were assayed. The occurrence of MACE was recorded during the 6-month follow-up and patients were assigned to MACE and non-MACE subgroups. Results The presence of symptomatic PAD was significantly correlated with age, diabetes, hsCRP, RBP4 and low adiponectin levels (p < 0.05). After adjustment for age, RBP4 (β = 0.498, p < 0.001), and adiponectin (β = –0.288, p < 0.001) levels remained as independent predictors of PAD presence in the whole study cohort. At baseline, MACE subgroup appeared with higher RBP-4 and hsCRP serum levels than non-MACE subgroup (p < 0.001), but no differences were detected for adiponectin (p = 0.758). Serum RBP4 levels remained independent predictor of MACE (β = 0.455, p < 0.001) after adjustment for traditional cardiovascular risk factors. Conclusions High RBP4 and low adiponectin serum levels are independently associated with PAD presence. In addition, RBP4 is an independent predictor of MACE incidence in symptomatic PAD patients.Nikolaos P. E. KadoglouEmmanouil KorakasChristos KarkosEirini MaratouIoannis KanonidisPanagiotis PlotasNikolaos PapanasParaskevi MoutsatsouIgnatios IkonomidisVaia LambadiariBMCarticleRBP4AdiponectinPeripheral artery diseaseMACEInflammationDiseases of the circulatory (Cardiovascular) systemRC666-701ENCardiovascular Diabetology, Vol 20, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	RBP4 Adiponectin Peripheral artery disease MACE Inflammation Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	RBP4 Adiponectin Peripheral artery disease MACE Inflammation Diseases of the circulatory (Cardiovascular) system RC666-701 Nikolaos P. E. Kadoglou Emmanouil Korakas Christos Karkos Eirini Maratou Ioannis Kanonidis Panagiotis Plotas Nikolaos Papanas Paraskevi Moutsatsou Ignatios Ikonomidis Vaia Lambadiari The prognostic role of RBP-4 and adiponectin in patients with peripheral arterial disease undergoing lower limb endovascular revascularization
description	Abstract Background RBP4 is an adipokine with an established role in atherosclerosis, while adiponectin has unique anti-inflammatory properties. We investigated the association of RBP4 and adiponectin with the presence of symptomatic peripheral artery disease (PAD) and their possible prognostic role in major adverse cardiovascular events (MACE). Methods We enrolled 168 consecutive patients with symptomatic, established PAD, requiring revascularization by endovascular means of any or both of their lower limbs. 88 age- and sex-matched subjects with less than 2 classical cardiovascular risk factors served as controls. Clinical parameters, glycemic and lipid profile, RBP4 and adiponectin levels were assayed. The occurrence of MACE was recorded during the 6-month follow-up and patients were assigned to MACE and non-MACE subgroups. Results The presence of symptomatic PAD was significantly correlated with age, diabetes, hsCRP, RBP4 and low adiponectin levels (p < 0.05). After adjustment for age, RBP4 (β = 0.498, p < 0.001), and adiponectin (β = –0.288, p < 0.001) levels remained as independent predictors of PAD presence in the whole study cohort. At baseline, MACE subgroup appeared with higher RBP-4 and hsCRP serum levels than non-MACE subgroup (p < 0.001), but no differences were detected for adiponectin (p = 0.758). Serum RBP4 levels remained independent predictor of MACE (β = 0.455, p < 0.001) after adjustment for traditional cardiovascular risk factors. Conclusions High RBP4 and low adiponectin serum levels are independently associated with PAD presence. In addition, RBP4 is an independent predictor of MACE incidence in symptomatic PAD patients.
format	article
author	Nikolaos P. E. Kadoglou Emmanouil Korakas Christos Karkos Eirini Maratou Ioannis Kanonidis Panagiotis Plotas Nikolaos Papanas Paraskevi Moutsatsou Ignatios Ikonomidis Vaia Lambadiari
author_facet	Nikolaos P. E. Kadoglou Emmanouil Korakas Christos Karkos Eirini Maratou Ioannis Kanonidis Panagiotis Plotas Nikolaos Papanas Paraskevi Moutsatsou Ignatios Ikonomidis Vaia Lambadiari
author_sort	Nikolaos P. E. Kadoglou
title	The prognostic role of RBP-4 and adiponectin in patients with peripheral arterial disease undergoing lower limb endovascular revascularization
title_short	The prognostic role of RBP-4 and adiponectin in patients with peripheral arterial disease undergoing lower limb endovascular revascularization
title_full	The prognostic role of RBP-4 and adiponectin in patients with peripheral arterial disease undergoing lower limb endovascular revascularization
title_fullStr	The prognostic role of RBP-4 and adiponectin in patients with peripheral arterial disease undergoing lower limb endovascular revascularization
title_full_unstemmed	The prognostic role of RBP-4 and adiponectin in patients with peripheral arterial disease undergoing lower limb endovascular revascularization
title_sort	prognostic role of rbp-4 and adiponectin in patients with peripheral arterial disease undergoing lower limb endovascular revascularization
publisher	BMC
publishDate	2021
url	https://doaj.org/article/11216b66928f4d9ca8345b7c32066a75
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The prognostic role of RBP-4 and adiponectin in patients with peripheral arterial disease undergoing lower limb endovascular revascularization

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