Complex formation of APP with GABAB receptors links axonal trafficking to amyloidogenic processing

The mechanisms that control the presynaptic abundance of GABAB receptors (GBRs) remains unclear. This study shows that sequence-related epitopes in APP, AJAP-1 and PIANP bind with nanomolar affinities to the N-terminal sushi-domain of presynaptic GBRs, and that selective loss of APP impaired GBR-med...

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Autores principales:	Margarita C. Dinamarca, Adi Raveh, Andy Schneider, Thorsten Fritzius, Simon Früh, Pascal D. Rem, Michal Stawarski, Txomin Lalanne, Rostislav Turecek, Myeongjeong Choo, Valérie Besseyrias, Wolfgang Bildl, Detlef Bentrop, Matthias Staufenbiel, Martin Gassmann, Bernd Fakler, Jochen Schwenk, Bernhard Bettler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1122aad37c3e4affaea79ae9d7612a6d
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spelling	oai:doaj.org-article:1122aad37c3e4affaea79ae9d7612a6d2021-12-02T16:57:20ZComplex formation of APP with GABAB receptors links axonal trafficking to amyloidogenic processing10.1038/s41467-019-09164-32041-1723https://doaj.org/article/1122aad37c3e4affaea79ae9d7612a6d2019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09164-3https://doaj.org/toc/2041-1723The mechanisms that control the presynaptic abundance of GABAB receptors (GBRs) remains unclear. This study shows that sequence-related epitopes in APP, AJAP-1 and PIANP bind with nanomolar affinities to the N-terminal sushi-domain of presynaptic GBRs, and that selective loss of APP impaired GBR-mediated presynaptic inhibition and axonal GBR expressionMargarita C. DinamarcaAdi RavehAndy SchneiderThorsten FritziusSimon FrühPascal D. RemMichal StawarskiTxomin LalanneRostislav TurecekMyeongjeong ChooValérie BesseyriasWolfgang BildlDetlef BentropMatthias StaufenbielMartin GassmannBernd FaklerJochen SchwenkBernhard BettlerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Margarita C. Dinamarca Adi Raveh Andy Schneider Thorsten Fritzius Simon Früh Pascal D. Rem Michal Stawarski Txomin Lalanne Rostislav Turecek Myeongjeong Choo Valérie Besseyrias Wolfgang Bildl Detlef Bentrop Matthias Staufenbiel Martin Gassmann Bernd Fakler Jochen Schwenk Bernhard Bettler Complex formation of APP with GABAB receptors links axonal trafficking to amyloidogenic processing
description	The mechanisms that control the presynaptic abundance of GABAB receptors (GBRs) remains unclear. This study shows that sequence-related epitopes in APP, AJAP-1 and PIANP bind with nanomolar affinities to the N-terminal sushi-domain of presynaptic GBRs, and that selective loss of APP impaired GBR-mediated presynaptic inhibition and axonal GBR expression
format	article
author	Margarita C. Dinamarca Adi Raveh Andy Schneider Thorsten Fritzius Simon Früh Pascal D. Rem Michal Stawarski Txomin Lalanne Rostislav Turecek Myeongjeong Choo Valérie Besseyrias Wolfgang Bildl Detlef Bentrop Matthias Staufenbiel Martin Gassmann Bernd Fakler Jochen Schwenk Bernhard Bettler
author_facet	Margarita C. Dinamarca Adi Raveh Andy Schneider Thorsten Fritzius Simon Früh Pascal D. Rem Michal Stawarski Txomin Lalanne Rostislav Turecek Myeongjeong Choo Valérie Besseyrias Wolfgang Bildl Detlef Bentrop Matthias Staufenbiel Martin Gassmann Bernd Fakler Jochen Schwenk Bernhard Bettler
author_sort	Margarita C. Dinamarca
title	Complex formation of APP with GABAB receptors links axonal trafficking to amyloidogenic processing
title_short	Complex formation of APP with GABAB receptors links axonal trafficking to amyloidogenic processing
title_full	Complex formation of APP with GABAB receptors links axonal trafficking to amyloidogenic processing
title_fullStr	Complex formation of APP with GABAB receptors links axonal trafficking to amyloidogenic processing
title_full_unstemmed	Complex formation of APP with GABAB receptors links axonal trafficking to amyloidogenic processing
title_sort	complex formation of app with gabab receptors links axonal trafficking to amyloidogenic processing
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/1122aad37c3e4affaea79ae9d7612a6d
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Complex formation of APP with GABAB receptors links axonal trafficking to amyloidogenic processing

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