Effect of Antioxidant Preparation «Mexidol» on the Protein Components of the Erythrocyte Cytoplasmic Membrane in Patients with Ulcerative Colitis

Background. Ulcerative colitis is a colon disease accompanied by a systemic inflammatory response with the development of oxidative stress, which leads to structural and functional changes in cell membranes. There are no data on the qualitative and quantitative changes in the protein components of t...

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Autores principales:	Yu. I. Pivovarov, L. A. Dmitrieva, A. S. Sergeeva, T. S. Yan'kova, O. V. Saj
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2020
Materias:	ulcerative colitis antioxidant proteins cytoplasmic membrane erythrocyte Science Q
Acceso en línea:	https://doaj.org/article/11233113d03440db88dd98dcb568c345
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spelling	oai:doaj.org-article:11233113d03440db88dd98dcb568c3452021-11-23T06:14:44ZEffect of Antioxidant Preparation «Mexidol» on the Protein Components of the Erythrocyte Cytoplasmic Membrane in Patients with Ulcerative Colitis2541-94202587-959610.29413/ABS.2020-5.2.10https://doaj.org/article/11233113d03440db88dd98dcb568c3452020-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/2309https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Background. Ulcerative colitis is a colon disease accompanied by a systemic inflammatory response with the development of oxidative stress, which leads to structural and functional changes in cell membranes. There are no data on the qualitative and quantitative changes in the protein components of the cytoplasmic membrane in ulcerative colitis under the influence of the antioxidant, membrane-stabilizing drug Mexidol.The article presents the data of our own research, the purpose of which is to study the nature of changes in protein components in the erythrocyte membrane in vitro when exposed to Mexidol (the active substance is oxymethylethyl peridine succinate) in patients with ulcerative colitis during an acute attack.Materials and methods. The study involved 51 patients with ulcerative colitis during the exacerbation period and 30 clinically healthy individuals comparable by sex and age. Ten major protein components of the erythrocyte membrane were evaluated.Results. As a result of the regression analysis, it was shown that in the group of clinically healthy individuals, almost all structural proteins are to varying degrees linked to proteins by glucose transporters and the enzyme glutathione-S-transferase and in patients with ulcerative colitis, the connection of protein components of membrane channels with spectrines is lost. Incubation of red blood cells of patients with ulcerative colitis in a solution of Mexidol in vitro did not affect the protein components of the erythrocyte cytoplasmic membrane. At the same time, in ulcerative colitis patients there was a restoration of spectrin connections with anion transport proteins and a glucose transporter, which were not detected in the initial state. Conclusion. The effect of Mexidol in vitro on the erythrocyte membranes of patients with ulcerative colitis was accompanied by the restoration of structural and functional protein bonds, which can be considered as a beneficial effect of this drug on the erythrocyte membrane under the conditions of the studied pathology.Yu. I. PivovarovL. A. DmitrievaA. S. SergeevaT. S. Yan'kovaO. V. SajScientific Сentre for Family Health and Human Reproduction Problemsarticleulcerative colitisantioxidantproteinscytoplasmic membraneerythrocyteScienceQRUActa Biomedica Scientifica, Vol 5, Iss 2, Pp 83-89 (2020)
institution	DOAJ
collection	DOAJ
language	RU
topic	ulcerative colitis antioxidant proteins cytoplasmic membrane erythrocyte Science Q
spellingShingle	ulcerative colitis antioxidant proteins cytoplasmic membrane erythrocyte Science Q Yu. I. Pivovarov L. A. Dmitrieva A. S. Sergeeva T. S. Yan'kova O. V. Saj Effect of Antioxidant Preparation «Mexidol» on the Protein Components of the Erythrocyte Cytoplasmic Membrane in Patients with Ulcerative Colitis
description	Background. Ulcerative colitis is a colon disease accompanied by a systemic inflammatory response with the development of oxidative stress, which leads to structural and functional changes in cell membranes. There are no data on the qualitative and quantitative changes in the protein components of the cytoplasmic membrane in ulcerative colitis under the influence of the antioxidant, membrane-stabilizing drug Mexidol.The article presents the data of our own research, the purpose of which is to study the nature of changes in protein components in the erythrocyte membrane in vitro when exposed to Mexidol (the active substance is oxymethylethyl peridine succinate) in patients with ulcerative colitis during an acute attack.Materials and methods. The study involved 51 patients with ulcerative colitis during the exacerbation period and 30 clinically healthy individuals comparable by sex and age. Ten major protein components of the erythrocyte membrane were evaluated.Results. As a result of the regression analysis, it was shown that in the group of clinically healthy individuals, almost all structural proteins are to varying degrees linked to proteins by glucose transporters and the enzyme glutathione-S-transferase and in patients with ulcerative colitis, the connection of protein components of membrane channels with spectrines is lost. Incubation of red blood cells of patients with ulcerative colitis in a solution of Mexidol in vitro did not affect the protein components of the erythrocyte cytoplasmic membrane. At the same time, in ulcerative colitis patients there was a restoration of spectrin connections with anion transport proteins and a glucose transporter, which were not detected in the initial state. Conclusion. The effect of Mexidol in vitro on the erythrocyte membranes of patients with ulcerative colitis was accompanied by the restoration of structural and functional protein bonds, which can be considered as a beneficial effect of this drug on the erythrocyte membrane under the conditions of the studied pathology.
format	article
author	Yu. I. Pivovarov L. A. Dmitrieva A. S. Sergeeva T. S. Yan'kova O. V. Saj
author_facet	Yu. I. Pivovarov L. A. Dmitrieva A. S. Sergeeva T. S. Yan'kova O. V. Saj
author_sort	Yu. I. Pivovarov
title	Effect of Antioxidant Preparation «Mexidol» on the Protein Components of the Erythrocyte Cytoplasmic Membrane in Patients with Ulcerative Colitis
title_short	Effect of Antioxidant Preparation «Mexidol» on the Protein Components of the Erythrocyte Cytoplasmic Membrane in Patients with Ulcerative Colitis
title_full	Effect of Antioxidant Preparation «Mexidol» on the Protein Components of the Erythrocyte Cytoplasmic Membrane in Patients with Ulcerative Colitis
title_fullStr	Effect of Antioxidant Preparation «Mexidol» on the Protein Components of the Erythrocyte Cytoplasmic Membrane in Patients with Ulcerative Colitis
title_full_unstemmed	Effect of Antioxidant Preparation «Mexidol» on the Protein Components of the Erythrocyte Cytoplasmic Membrane in Patients with Ulcerative Colitis
title_sort	effect of antioxidant preparation «mexidol» on the protein components of the erythrocyte cytoplasmic membrane in patients with ulcerative colitis
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2020
url	https://doaj.org/article/11233113d03440db88dd98dcb568c345
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Effect of Antioxidant Preparation «Mexidol» on the Protein Components of the Erythrocyte Cytoplasmic Membrane in Patients with Ulcerative Colitis

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