Motor matters: tackling heterogeneity of Parkinson's disease in functional MRI studies.

To tackle the heterogeneity of Parkinson's disease symptoms, most functional imaging studies tend to select a uniform group of subjects. We hypothesize that more profound considerations are needed to account for intra/inter-subject clinical variability and possibly for differing pathophysiologi...

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Autores principales:	Štefan Holiga, Karsten Mueller, Harald E Möller, Tomáš Sieger, Matthias L Schroeter, Josef Vymazal, Evžen Růžička, Robert Jech
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/112350cadaff42f68b91ba2a71f2e1e4
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spelling	oai:doaj.org-article:112350cadaff42f68b91ba2a71f2e1e42021-11-18T07:57:42ZMotor matters: tackling heterogeneity of Parkinson's disease in functional MRI studies.1932-620310.1371/journal.pone.0056133https://doaj.org/article/112350cadaff42f68b91ba2a71f2e1e42013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23418522/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203To tackle the heterogeneity of Parkinson's disease symptoms, most functional imaging studies tend to select a uniform group of subjects. We hypothesize that more profound considerations are needed to account for intra/inter-subject clinical variability and possibly for differing pathophysiological processes. Twelve patients were investigated using functional magnetic resonance imaging during visually-guided finger tapping. To account for disease heterogeneity, the motor score and individual symptom scores from the Unified Parkinson's Disease Rating Scale (UPDRS-III) were utilized in the group-level model using two approaches either as the explanatory variable or as the effect of interest. Employment of the UPDRS-III score and symptom scores was systematically tested on the resulting group response to the levodopa challenge, which further accentuated the diversity of the diseased state of participants. Statistics revealed a bilateral group response to levodopa in the basal ganglia. Interestingly, systematic incorporation of individual motor aspects of the disease in the modelling amended the resulting activity patterns conspicuously, evidencing a manifold amount of explained variability by the particular score. In conclusion, the severity of clinical symptoms expressed in the UPDRS-III scores should be considered in the analysis to attain unbiased statistics, draw reliable conclusions and allow for comparisons between research groups studying Parkinson's disease using functional magnetic resonance imaging.Štefan HoligaKarsten MuellerHarald E MöllerTomáš SiegerMatthias L SchroeterJosef VymazalEvžen RůžičkaRobert JechPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 2, p e56133 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Štefan Holiga Karsten Mueller Harald E Möller Tomáš Sieger Matthias L Schroeter Josef Vymazal Evžen Růžička Robert Jech Motor matters: tackling heterogeneity of Parkinson's disease in functional MRI studies.
description	To tackle the heterogeneity of Parkinson's disease symptoms, most functional imaging studies tend to select a uniform group of subjects. We hypothesize that more profound considerations are needed to account for intra/inter-subject clinical variability and possibly for differing pathophysiological processes. Twelve patients were investigated using functional magnetic resonance imaging during visually-guided finger tapping. To account for disease heterogeneity, the motor score and individual symptom scores from the Unified Parkinson's Disease Rating Scale (UPDRS-III) were utilized in the group-level model using two approaches either as the explanatory variable or as the effect of interest. Employment of the UPDRS-III score and symptom scores was systematically tested on the resulting group response to the levodopa challenge, which further accentuated the diversity of the diseased state of participants. Statistics revealed a bilateral group response to levodopa in the basal ganglia. Interestingly, systematic incorporation of individual motor aspects of the disease in the modelling amended the resulting activity patterns conspicuously, evidencing a manifold amount of explained variability by the particular score. In conclusion, the severity of clinical symptoms expressed in the UPDRS-III scores should be considered in the analysis to attain unbiased statistics, draw reliable conclusions and allow for comparisons between research groups studying Parkinson's disease using functional magnetic resonance imaging.
format	article
author	Štefan Holiga Karsten Mueller Harald E Möller Tomáš Sieger Matthias L Schroeter Josef Vymazal Evžen Růžička Robert Jech
author_facet	Štefan Holiga Karsten Mueller Harald E Möller Tomáš Sieger Matthias L Schroeter Josef Vymazal Evžen Růžička Robert Jech
author_sort	Štefan Holiga
title	Motor matters: tackling heterogeneity of Parkinson's disease in functional MRI studies.
title_short	Motor matters: tackling heterogeneity of Parkinson's disease in functional MRI studies.
title_full	Motor matters: tackling heterogeneity of Parkinson's disease in functional MRI studies.
title_fullStr	Motor matters: tackling heterogeneity of Parkinson's disease in functional MRI studies.
title_full_unstemmed	Motor matters: tackling heterogeneity of Parkinson's disease in functional MRI studies.
title_sort	motor matters: tackling heterogeneity of parkinson's disease in functional mri studies.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/112350cadaff42f68b91ba2a71f2e1e4
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Motor matters: tackling heterogeneity of Parkinson's disease in functional MRI studies.

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