Orbitofrontal-striatal potentiation underlies cocaine-induced hyperactivity

Psychomotor stimulants increase dopamine levels in the striatum and promote locomotion but their effects on striatal pathways in vivo remain unclear. The authors show that cocaine increases the activity of direct and indirect pathway striatal neurons of awake mice via the orbitofrontal cortex.

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Detalles Bibliográficos
Autores principales: Sebastiano Bariselli, Nanami L. Miyazaki, Meaghan C. Creed, Alexxai V. Kravitz
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/11279baa460f42f3821b78a25dcfa37a
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Descripción
Sumario:Psychomotor stimulants increase dopamine levels in the striatum and promote locomotion but their effects on striatal pathways in vivo remain unclear. The authors show that cocaine increases the activity of direct and indirect pathway striatal neurons of awake mice via the orbitofrontal cortex.