Orbitofrontal-striatal potentiation underlies cocaine-induced hyperactivity

Psychomotor stimulants increase dopamine levels in the striatum and promote locomotion but their effects on striatal pathways in vivo remain unclear. The authors show that cocaine increases the activity of direct and indirect pathway striatal neurons of awake mice via the orbitofrontal cortex.

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Autores principales:	Sebastiano Bariselli, Nanami L. Miyazaki, Meaghan C. Creed, Alexxai V. Kravitz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/11279baa460f42f3821b78a25dcfa37a
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spelling	oai:doaj.org-article:11279baa460f42f3821b78a25dcfa37a2021-12-02T16:27:51ZOrbitofrontal-striatal potentiation underlies cocaine-induced hyperactivity10.1038/s41467-020-17763-82041-1723https://doaj.org/article/11279baa460f42f3821b78a25dcfa37a2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17763-8https://doaj.org/toc/2041-1723Psychomotor stimulants increase dopamine levels in the striatum and promote locomotion but their effects on striatal pathways in vivo remain unclear. The authors show that cocaine increases the activity of direct and indirect pathway striatal neurons of awake mice via the orbitofrontal cortex.Sebastiano BariselliNanami L. MiyazakiMeaghan C. CreedAlexxai V. KravitzNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sebastiano Bariselli Nanami L. Miyazaki Meaghan C. Creed Alexxai V. Kravitz Orbitofrontal-striatal potentiation underlies cocaine-induced hyperactivity
description	Psychomotor stimulants increase dopamine levels in the striatum and promote locomotion but their effects on striatal pathways in vivo remain unclear. The authors show that cocaine increases the activity of direct and indirect pathway striatal neurons of awake mice via the orbitofrontal cortex.
format	article
author	Sebastiano Bariselli Nanami L. Miyazaki Meaghan C. Creed Alexxai V. Kravitz
author_facet	Sebastiano Bariselli Nanami L. Miyazaki Meaghan C. Creed Alexxai V. Kravitz
author_sort	Sebastiano Bariselli
title	Orbitofrontal-striatal potentiation underlies cocaine-induced hyperactivity
title_short	Orbitofrontal-striatal potentiation underlies cocaine-induced hyperactivity
title_full	Orbitofrontal-striatal potentiation underlies cocaine-induced hyperactivity
title_fullStr	Orbitofrontal-striatal potentiation underlies cocaine-induced hyperactivity
title_full_unstemmed	Orbitofrontal-striatal potentiation underlies cocaine-induced hyperactivity
title_sort	orbitofrontal-striatal potentiation underlies cocaine-induced hyperactivity
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/11279baa460f42f3821b78a25dcfa37a
work_keys_str_mv	AT sebastianobariselli orbitofrontalstriatalpotentiationunderliescocaineinducedhyperactivity AT nanamilmiyazaki orbitofrontalstriatalpotentiationunderliescocaineinducedhyperactivity AT meaghanccreed orbitofrontalstriatalpotentiationunderliescocaineinducedhyperactivity AT alexxaivkravitz orbitofrontalstriatalpotentiationunderliescocaineinducedhyperactivity
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Orbitofrontal-striatal potentiation underlies cocaine-induced hyperactivity

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