Integration of adeno-associated virus (AAV) into the genomes of most Thai and Mongolian liver cancer patients does not induce oncogenesis

Integration of adeno-associated virus (AAV) into the genomes of most Thai and Mongolian liver cancer patients does not induce oncogenesis

Abstract Background Engineered versions of adeno-associated virus (AAV) are commonly used in gene therapy but evidence revealing a potential oncogenic role of natural AAV in hepatocellular carcinoma (HCC) has raised concerns. The frequency of potentially oncogenic integrations has been reported in o...

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Main Authors: Alejandro A. Schäffer, Dana A. Dominguez, Lesley M. Chapman, E. Michael Gertz, Anuradha Budhu, Marshonna Forgues, Jittiporn Chaisaingmongkol, Siritida Rabibhadana, Benjarath Pupacdi, Xiaolin Wu, Enkhjargal Bayarsaikhan, Curtis C. Harris, Mathuros Ruchirawat, Eytan Ruppin, Xin Wei Wang
Format: article
Language:EN
Published: BMC 2021
Subjects:
Liver cancer
Hepatocellular carcinoma
Intrahepatic cholangiocarcinoma
Adeno-associated virus
Virus integration
Viral oncogenesis
Biotechnology
TP248.13-248.65
Genetics
QH426-470
Online Access:https://doaj.org/article/112941e99568473c8c4542fa2d87f042
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https://doaj.org/article/112941e99568473c8c4542fa2d87f042

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