Activity in a premotor cortical nucleus of zebra finches is locally organized and exhibits auditory selectivity in neurons but not in glia.
Motor functions are often guided by sensory experience, most convincingly illustrated by complex learned behaviors. Key to sensory guidance in motor areas may be the structural and functional organization of sensory inputs and their evoked responses. We study sensory responses in large populations o...
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2013
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oai:doaj.org-article:112ac791f230432aa5409f378f87d26d2021-11-18T08:43:46ZActivity in a premotor cortical nucleus of zebra finches is locally organized and exhibits auditory selectivity in neurons but not in glia.1932-620310.1371/journal.pone.0081177https://doaj.org/article/112ac791f230432aa5409f378f87d26d2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24312533/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Motor functions are often guided by sensory experience, most convincingly illustrated by complex learned behaviors. Key to sensory guidance in motor areas may be the structural and functional organization of sensory inputs and their evoked responses. We study sensory responses in large populations of neurons and neuron-assistive cells in the songbird motor area HVC, an auditory-vocal brain area involved in sensory learning and in adult song production. HVC spike responses to auditory stimulation display remarkable preference for the bird's own song (BOS) compared to other stimuli. Using two-photon calcium imaging in anesthetized zebra finches we measure the spatio-temporal structure of baseline activity and of auditory evoked responses in identified populations of HVC cells. We find strong correlations between calcium signal fluctuations in nearby cells of a given type, both in identified neurons and in astroglia. In identified HVC neurons only, auditory stimulation decorrelates ongoing calcium signals, less for BOS than for other sound stimuli. Overall, calcium transients show strong preference for BOS in identified HVC neurons but not in astroglia, showing diversity in local functional organization among identified neuron and astroglia populations.Michael H GraberFritjof HelmchenRichard H R HahnloserPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 12, p e81177 (2013) |
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Medicine R Science Q |
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Medicine R Science Q Michael H Graber Fritjof Helmchen Richard H R Hahnloser Activity in a premotor cortical nucleus of zebra finches is locally organized and exhibits auditory selectivity in neurons but not in glia. |
| description |
Motor functions are often guided by sensory experience, most convincingly illustrated by complex learned behaviors. Key to sensory guidance in motor areas may be the structural and functional organization of sensory inputs and their evoked responses. We study sensory responses in large populations of neurons and neuron-assistive cells in the songbird motor area HVC, an auditory-vocal brain area involved in sensory learning and in adult song production. HVC spike responses to auditory stimulation display remarkable preference for the bird's own song (BOS) compared to other stimuli. Using two-photon calcium imaging in anesthetized zebra finches we measure the spatio-temporal structure of baseline activity and of auditory evoked responses in identified populations of HVC cells. We find strong correlations between calcium signal fluctuations in nearby cells of a given type, both in identified neurons and in astroglia. In identified HVC neurons only, auditory stimulation decorrelates ongoing calcium signals, less for BOS than for other sound stimuli. Overall, calcium transients show strong preference for BOS in identified HVC neurons but not in astroglia, showing diversity in local functional organization among identified neuron and astroglia populations. |
| format |
article |
| author |
Michael H Graber Fritjof Helmchen Richard H R Hahnloser |
| author_facet |
Michael H Graber Fritjof Helmchen Richard H R Hahnloser |
| author_sort |
Michael H Graber |
| title |
Activity in a premotor cortical nucleus of zebra finches is locally organized and exhibits auditory selectivity in neurons but not in glia. |
| title_short |
Activity in a premotor cortical nucleus of zebra finches is locally organized and exhibits auditory selectivity in neurons but not in glia. |
| title_full |
Activity in a premotor cortical nucleus of zebra finches is locally organized and exhibits auditory selectivity in neurons but not in glia. |
| title_fullStr |
Activity in a premotor cortical nucleus of zebra finches is locally organized and exhibits auditory selectivity in neurons but not in glia. |
| title_full_unstemmed |
Activity in a premotor cortical nucleus of zebra finches is locally organized and exhibits auditory selectivity in neurons but not in glia. |
| title_sort |
activity in a premotor cortical nucleus of zebra finches is locally organized and exhibits auditory selectivity in neurons but not in glia. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2013 |
| url |
https://doaj.org/article/112ac791f230432aa5409f378f87d26d |
| work_keys_str_mv |
AT michaelhgraber activityinapremotorcorticalnucleusofzebrafinchesislocallyorganizedandexhibitsauditoryselectivityinneuronsbutnotinglia AT fritjofhelmchen activityinapremotorcorticalnucleusofzebrafinchesislocallyorganizedandexhibitsauditoryselectivityinneuronsbutnotinglia AT richardhrhahnloser activityinapremotorcorticalnucleusofzebrafinchesislocallyorganizedandexhibitsauditoryselectivityinneuronsbutnotinglia |
| _version_ |
1718421365331066880 |