HSC-explorer: a curated database for hematopoietic stem cells.

HSC-Explorer (http://mips.helmholtz-muenchen.de/HSC/) is a publicly available, integrative database containing detailed information about the early steps of hematopoiesis. The resource aims at providing fast and easy access to relevant information, in particular to the complex network of interacting...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Corinna Montrone, Konstantinos D Kokkaliaris, Dirk Loeffler, Martin Lechner, Gabi Kastenmüller, Timm Schroeder, Andreas Ruepp
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/112bcae3db2f46e7b04805379ebe13e3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:112bcae3db2f46e7b04805379ebe13e3
record_format	dspace
spelling	oai:doaj.org-article:112bcae3db2f46e7b04805379ebe13e32021-11-18T09:01:58ZHSC-explorer: a curated database for hematopoietic stem cells.1932-620310.1371/journal.pone.0070348https://doaj.org/article/112bcae3db2f46e7b04805379ebe13e32013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23936191/?tool=EBIhttps://doaj.org/toc/1932-6203HSC-Explorer (http://mips.helmholtz-muenchen.de/HSC/) is a publicly available, integrative database containing detailed information about the early steps of hematopoiesis. The resource aims at providing fast and easy access to relevant information, in particular to the complex network of interacting cell types and molecules, from the wealth of publications in the field through visualization interfaces. It provides structured information on more than 7000 experimentally validated interactions between molecules, bioprocesses and environmental factors. Information is manually derived by critical reading of the scientific literature from expert annotators. Hematopoiesis-relevant interactions are accompanied with context information such as model organisms and experimental methods for enabling assessment of reliability and relevance of experimental results. Usage of established vocabularies facilitates downstream bioinformatics applications and to convert the results into complex networks. Several predefined datasets (Selected topics) offer insights into stem cell behavior, the stem cell niche and signaling processes supporting hematopoietic stem cell maintenance. HSC-Explorer provides a versatile web-based resource for scientists entering the field of hematopoiesis enabling users to inspect the associated biological processes through interactive graphical presentation.Corinna MontroneKonstantinos D KokkaliarisDirk LoefflerMartin LechnerGabi KastenmüllerTimm SchroederAndreas RueppPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 7, p e70348 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Corinna Montrone Konstantinos D Kokkaliaris Dirk Loeffler Martin Lechner Gabi Kastenmüller Timm Schroeder Andreas Ruepp HSC-explorer: a curated database for hematopoietic stem cells.
description	HSC-Explorer (http://mips.helmholtz-muenchen.de/HSC/) is a publicly available, integrative database containing detailed information about the early steps of hematopoiesis. The resource aims at providing fast and easy access to relevant information, in particular to the complex network of interacting cell types and molecules, from the wealth of publications in the field through visualization interfaces. It provides structured information on more than 7000 experimentally validated interactions between molecules, bioprocesses and environmental factors. Information is manually derived by critical reading of the scientific literature from expert annotators. Hematopoiesis-relevant interactions are accompanied with context information such as model organisms and experimental methods for enabling assessment of reliability and relevance of experimental results. Usage of established vocabularies facilitates downstream bioinformatics applications and to convert the results into complex networks. Several predefined datasets (Selected topics) offer insights into stem cell behavior, the stem cell niche and signaling processes supporting hematopoietic stem cell maintenance. HSC-Explorer provides a versatile web-based resource for scientists entering the field of hematopoiesis enabling users to inspect the associated biological processes through interactive graphical presentation.
format	article
author	Corinna Montrone Konstantinos D Kokkaliaris Dirk Loeffler Martin Lechner Gabi Kastenmüller Timm Schroeder Andreas Ruepp
author_facet	Corinna Montrone Konstantinos D Kokkaliaris Dirk Loeffler Martin Lechner Gabi Kastenmüller Timm Schroeder Andreas Ruepp
author_sort	Corinna Montrone
title	HSC-explorer: a curated database for hematopoietic stem cells.
title_short	HSC-explorer: a curated database for hematopoietic stem cells.
title_full	HSC-explorer: a curated database for hematopoietic stem cells.
title_fullStr	HSC-explorer: a curated database for hematopoietic stem cells.
title_full_unstemmed	HSC-explorer: a curated database for hematopoietic stem cells.
title_sort	hsc-explorer: a curated database for hematopoietic stem cells.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/112bcae3db2f46e7b04805379ebe13e3
work_keys_str_mv	AT corinnamontrone hscexploreracurateddatabaseforhematopoieticstemcells AT konstantinosdkokkaliaris hscexploreracurateddatabaseforhematopoieticstemcells AT dirkloeffler hscexploreracurateddatabaseforhematopoieticstemcells AT martinlechner hscexploreracurateddatabaseforhematopoieticstemcells AT gabikastenmuller hscexploreracurateddatabaseforhematopoieticstemcells AT timmschroeder hscexploreracurateddatabaseforhematopoieticstemcells AT andreasruepp hscexploreracurateddatabaseforhematopoieticstemcells
_version_	1718421006731706368

HSC-explorer: a curated database for hematopoietic stem cells.

Ejemplares similares