Rapid mineralization of hierarchical poly(l-lactic acid)/poly(ε-caprolactone) nanofibrous scaffolds by electrodeposition for bone regeneration

Rapid mineralization of hierarchical poly(l-lactic acid)/poly(ε-caprolactone) nanofibrous scaffolds by electrodeposition for bone regeneration

Wei Nie,1,2,* Yiming Gao,3,* David James McCoul,2 Gregory James Gillispie,2 YanZhong Zhang,1 Li Liang,4 ChuangLong He11State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, Pe...

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Autores principales: Nie W, Gao Y, McCoul DJ, Gillispie GJ, Zhang Y, Liang L, He C
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2019
Materias:
mineralization
hierarchical porous scaffold
electrodeposition
bone repair
Medicine (General)
R5-920
Acceso en línea:https://doaj.org/article/112f1bb99b7a4f9a904f03c060211bdf
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spelling oai:doaj.org-article:112f1bb99b7a4f9a904f03c060211bdf2021-12-02T04:30:33ZRapid mineralization of hierarchical poly(l-lactic acid)/poly(ε-caprolactone) nanofibrous scaffolds by electrodeposition for bone regeneration1178-2013https://doaj.org/article/112f1bb99b7a4f9a904f03c060211bdf2019-05-01T00:00:00Zhttps://www.dovepress.com/rapid-mineralization-of-hierarchical-polyl-lactic-acidpolyepsilon-capr-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Wei Nie,1,2,* Yiming Gao,3,* David James McCoul,2 Gregory James Gillispie,2 YanZhong Zhang,1 Li Liang,4 ChuangLong He11State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, People’s Republic of China; 2Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston Salem, NC 27103, USA; 3Department of Plastic and Cosmetic Surgery, Shanghai Traditional Chinese Medicine University Affiliated Shuguang Hospital, Shanghai 201203, People’s Republic of China; 4Department of Respiratory Medicine, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201999, People’s Republic of China *These authors contributed equally to this workIntroduction: Hierarchical nanofibrous scaffolds are emerging as a promising bone repair material due to their high cell adhesion activity and nutrient permeability. However, the existing method for hierarchical nanofibrous scaffolds fabrication is complicated and not perfectly suitable for further biomedical application in view of both structure and function. In this study, we constructed a hierarchical nanofibrous poly (l-lactic acid)/poly(ϵ-caprolactone) (PLLA/PCL) scaffold and further evaluated its bone healing ability.Methods: The hierarchical PLLA/PCL nanofibrous scaffold (PLLA/PCL) was prepared by one-pot TIPS and then rapidly mineralized at room temperature by an electrochemical deposition technique. After electrode-positioning at 2 V for 2 hrs, a scaffold coated with hydroxyapatite (M-PLLA/PCL) could be obtained.Results: The pore size of the M-PLLA/PCL scaffold was hierarchically distributed so as to match the biophysical structure for osteoblast growth. The M-PLLA/PCL scaffold showed better cell proliferation and osteogenesis activity compared to the PLLA/PCL scaffold. Further in vivo bone repair studies indicated that the M-PLLA/PCL scaffold could accelerate defect healing in 12 weeks.Conclusion: The results of this study implied that the as-prepared hydroxyapatite coated hierarchical PLLA/PCL nanofibrous scaffolds could be developed as a promising material for efficient bone tissue repair after carefully tuning the TIPS and electrodeposition parameters.Keywords: mineralization, hierarchical porous scaffold, electrodeposition, bone repairNie WGao YMcCoul DJGillispie GJZhang YLiang LHe CDove Medical Pressarticlemineralizationhierarchical porous scaffoldelectrodepositionbone repairMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 3929-3941 (2019)
institution DOAJ
collection DOAJ
language EN
topic mineralization
hierarchical porous scaffold
electrodeposition
bone repair
Medicine (General)
R5-920
spellingShingle mineralization
hierarchical porous scaffold
electrodeposition
bone repair
Medicine (General)
R5-920
Nie W
Gao Y
McCoul DJ
Gillispie GJ
Zhang Y
Liang L
He C
Rapid mineralization of hierarchical poly(l-lactic acid)/poly(ε-caprolactone) nanofibrous scaffolds by electrodeposition for bone regeneration
description Wei Nie,1,2,* Yiming Gao,3,* David James McCoul,2 Gregory James Gillispie,2 YanZhong Zhang,1 Li Liang,4 ChuangLong He11State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, People’s Republic of China; 2Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston Salem, NC 27103, USA; 3Department of Plastic and Cosmetic Surgery, Shanghai Traditional Chinese Medicine University Affiliated Shuguang Hospital, Shanghai 201203, People’s Republic of China; 4Department of Respiratory Medicine, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201999, People’s Republic of China *These authors contributed equally to this workIntroduction: Hierarchical nanofibrous scaffolds are emerging as a promising bone repair material due to their high cell adhesion activity and nutrient permeability. However, the existing method for hierarchical nanofibrous scaffolds fabrication is complicated and not perfectly suitable for further biomedical application in view of both structure and function. In this study, we constructed a hierarchical nanofibrous poly (l-lactic acid)/poly(ϵ-caprolactone) (PLLA/PCL) scaffold and further evaluated its bone healing ability.Methods: The hierarchical PLLA/PCL nanofibrous scaffold (PLLA/PCL) was prepared by one-pot TIPS and then rapidly mineralized at room temperature by an electrochemical deposition technique. After electrode-positioning at 2 V for 2 hrs, a scaffold coated with hydroxyapatite (M-PLLA/PCL) could be obtained.Results: The pore size of the M-PLLA/PCL scaffold was hierarchically distributed so as to match the biophysical structure for osteoblast growth. The M-PLLA/PCL scaffold showed better cell proliferation and osteogenesis activity compared to the PLLA/PCL scaffold. Further in vivo bone repair studies indicated that the M-PLLA/PCL scaffold could accelerate defect healing in 12 weeks.Conclusion: The results of this study implied that the as-prepared hydroxyapatite coated hierarchical PLLA/PCL nanofibrous scaffolds could be developed as a promising material for efficient bone tissue repair after carefully tuning the TIPS and electrodeposition parameters.Keywords: mineralization, hierarchical porous scaffold, electrodeposition, bone repair
format article
author Nie W
Gao Y
McCoul DJ
Gillispie GJ
Zhang Y
Liang L
He C
author_facet Nie W
Gao Y
McCoul DJ
Gillispie GJ
Zhang Y
Liang L
He C
author_sort Nie W
title Rapid mineralization of hierarchical poly(l-lactic acid)/poly(ε-caprolactone) nanofibrous scaffolds by electrodeposition for bone regeneration
title_short Rapid mineralization of hierarchical poly(l-lactic acid)/poly(ε-caprolactone) nanofibrous scaffolds by electrodeposition for bone regeneration
title_full Rapid mineralization of hierarchical poly(l-lactic acid)/poly(ε-caprolactone) nanofibrous scaffolds by electrodeposition for bone regeneration
title_fullStr Rapid mineralization of hierarchical poly(l-lactic acid)/poly(ε-caprolactone) nanofibrous scaffolds by electrodeposition for bone regeneration
title_full_unstemmed Rapid mineralization of hierarchical poly(l-lactic acid)/poly(ε-caprolactone) nanofibrous scaffolds by electrodeposition for bone regeneration
title_sort rapid mineralization of hierarchical poly(l-lactic acid)/poly(ε-caprolactone) nanofibrous scaffolds by electrodeposition for bone regeneration
publisher Dove Medical Press
publishDate 2019
url https://doaj.org/article/112f1bb99b7a4f9a904f03c060211bdf
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