Increased frequency of Th17 cells and IL-17 levels are associated with low bone mineral density in postmenopausal women

Abstract Osteoporosis is one of the chronic and often neglected bone diseases in aging postmenopausal women that affect the quality of life. Studies on ovariectomized mice models indicated the reciprocal role of Th17 cells and Treg cells in the aetiology of osteoporosis. While Th17 cells promote ost...

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Autores principales:	Hetal Bhadricha, Vainav Patel, Amit Kumar Singh, Lalita Savardekar, Anushree Patil, Suchitra Surve, Meena Desai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1130ace943b04f2481654ffc8f2fe07f
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spelling	oai:doaj.org-article:1130ace943b04f2481654ffc8f2fe07f2021-12-02T19:06:44ZIncreased frequency of Th17 cells and IL-17 levels are associated with low bone mineral density in postmenopausal women10.1038/s41598-021-95640-02045-2322https://doaj.org/article/1130ace943b04f2481654ffc8f2fe07f2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95640-0https://doaj.org/toc/2045-2322Abstract Osteoporosis is one of the chronic and often neglected bone diseases in aging postmenopausal women that affect the quality of life. Studies on ovariectomized mice models indicated the reciprocal role of Th17 cells and Treg cells in the aetiology of osteoporosis. While Th17 cells promote osteoclastogenesis, Treg cells exhibit anti-osteoclastogenic activity. This exploratory study aimed to determine the difference in the frequency of these T-cell subtypes in pre-and postmenopausal women and to examine their association with BMD. In our study, the frequency of Treg cells, analyzed by flow cytometry, did not differ between pre-and postmenopausal women. However, plasma levels of IL-10 along with IL-10+CD4+T cells were higher in post- compared to premenopausal women. The frequency of Th17 cells was higher in postmenopausal women irrespective of their BMD, however, only postmenopausal women with low BMD had elevated IL-17 levels and their T-scores were associated with Th17 frequency. Collectively, the results suggest that estrogen insufficiency in postmenopausal women may lead to increased Th17 cell frequency and elevated IL-17 levels which are associated with low BMD. This study highlights, Th17 cells and IL-17 as key players in the pathogenesis of osteoporosis and they can be the potential targets for immunotherapy in the treatment of osteoporosis.Hetal BhadrichaVainav PatelAmit Kumar SinghLalita SavardekarAnushree PatilSuchitra SurveMeena DesaiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hetal Bhadricha Vainav Patel Amit Kumar Singh Lalita Savardekar Anushree Patil Suchitra Surve Meena Desai Increased frequency of Th17 cells and IL-17 levels are associated with low bone mineral density in postmenopausal women
description	Abstract Osteoporosis is one of the chronic and often neglected bone diseases in aging postmenopausal women that affect the quality of life. Studies on ovariectomized mice models indicated the reciprocal role of Th17 cells and Treg cells in the aetiology of osteoporosis. While Th17 cells promote osteoclastogenesis, Treg cells exhibit anti-osteoclastogenic activity. This exploratory study aimed to determine the difference in the frequency of these T-cell subtypes in pre-and postmenopausal women and to examine their association with BMD. In our study, the frequency of Treg cells, analyzed by flow cytometry, did not differ between pre-and postmenopausal women. However, plasma levels of IL-10 along with IL-10+CD4+T cells were higher in post- compared to premenopausal women. The frequency of Th17 cells was higher in postmenopausal women irrespective of their BMD, however, only postmenopausal women with low BMD had elevated IL-17 levels and their T-scores were associated with Th17 frequency. Collectively, the results suggest that estrogen insufficiency in postmenopausal women may lead to increased Th17 cell frequency and elevated IL-17 levels which are associated with low BMD. This study highlights, Th17 cells and IL-17 as key players in the pathogenesis of osteoporosis and they can be the potential targets for immunotherapy in the treatment of osteoporosis.
format	article
author	Hetal Bhadricha Vainav Patel Amit Kumar Singh Lalita Savardekar Anushree Patil Suchitra Surve Meena Desai
author_facet	Hetal Bhadricha Vainav Patel Amit Kumar Singh Lalita Savardekar Anushree Patil Suchitra Surve Meena Desai
author_sort	Hetal Bhadricha
title	Increased frequency of Th17 cells and IL-17 levels are associated with low bone mineral density in postmenopausal women
title_short	Increased frequency of Th17 cells and IL-17 levels are associated with low bone mineral density in postmenopausal women
title_full	Increased frequency of Th17 cells and IL-17 levels are associated with low bone mineral density in postmenopausal women
title_fullStr	Increased frequency of Th17 cells and IL-17 levels are associated with low bone mineral density in postmenopausal women
title_full_unstemmed	Increased frequency of Th17 cells and IL-17 levels are associated with low bone mineral density in postmenopausal women
title_sort	increased frequency of th17 cells and il-17 levels are associated with low bone mineral density in postmenopausal women
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1130ace943b04f2481654ffc8f2fe07f
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Increased frequency of Th17 cells and IL-17 levels are associated with low bone mineral density in postmenopausal women

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