Changes in Plasma Growth Differentiation Factor-15 After Laparoscopic Sleeve Gastrectomy in Morbidly Obese Patients: A Prospective Study
Ahmed Salman,1 Hossam El-Din Shaaban,2 Mohamed Salman,3 Sayed M Seif El Nasr,1 Ahmed Soliman,1 Abdoh Salem,4 Mohamed Tag El-Din,4 Hani Maurice Sabri Mikhail,3 Heba El Domiaty,5 Nesrin Abd Allah,6 Ghada MK GabAllah,7 Ahmed Youssef1 1Internal Medicine Department, Faculty of Medicine, Cairo University,...
Guardado en:
| Autores principales: | , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Dove Medical Press
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/113cb29425a94b2abd57b139389731f1 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:113cb29425a94b2abd57b139389731f1 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:113cb29425a94b2abd57b139389731f12021-12-02T14:38:05ZChanges in Plasma Growth Differentiation Factor-15 After Laparoscopic Sleeve Gastrectomy in Morbidly Obese Patients: A Prospective Study1178-7031https://doaj.org/article/113cb29425a94b2abd57b139389731f12021-04-01T00:00:00Zhttps://www.dovepress.com/changes-in-plasma-growth-differentiation-factor-15-after-laparoscopic--peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Ahmed Salman,1 Hossam El-Din Shaaban,2 Mohamed Salman,3 Sayed M Seif El Nasr,1 Ahmed Soliman,1 Abdoh Salem,4 Mohamed Tag El-Din,4 Hani Maurice Sabri Mikhail,3 Heba El Domiaty,5 Nesrin Abd Allah,6 Ghada MK GabAllah,7 Ahmed Youssef1 1Internal Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt; 2Gastroenterology Department, National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt; 3General Surgery Department, Faculty of Medicine, Cairo University, Cairo, Egypt; 4General Surgery Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt; 5Clinical Physiology Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt; 6Anatomy and Embryology Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt; 7Medical Biochemistry Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, EgyptCorrespondence: Ahmed SalmanInternal Medicine Department, Faculty of Medicine, Cairo University, Cairo, EgyptTel +20 1000468664Email awea844@gmail.comPurpose: This study aimed to assess the potential changes of Growth differentiation factor 15 (GDF15) after laparoscopic sleeve gastrectomy (LSG) in morbidly obese patients.Methods: We conducted a prospective study on 68 patients who underwent LSG and 58 cases, who were enrolled as a control group, to whom conservative measures of weight loss were adopted. Both groups were followed for 12 months.Results: At the baseline, the serum GDF15 was comparable between LSG and conservative groups (409.93± 119 versus 385.8± 120.2 pg/mL, p =0.246). However, at 12 months after the operation, the serum GDF15 was significantly higher in the LSG than conservative groups (699.941 ± 193.5 versus 559 ± 159.7; p < 0.001). The degree of serum GDF15 increase was higher in the LSG group (290.01 ± 189.9 versus 173.14 ± 116.7; p < 0.001). The degree of serum GDF15 increase correlated negatively with the final BMI (r = − 0.352, p =0.001) and weight loss (r = − 0.793, p =0.001) at 12 months after the operation. The correlation analysis demonstrated that the initial GFD15 did not correlate with any baseline parameters. Multiple regression analysis of change in serum GDF15 showed a statistical significance of the weight loss after 12 months.Conclusion: The present work confirms the impact of successful weight loss on the circulating level of GDF15. Our study demonstrated that the circulating GDF15 increased significantly after LSG and it was correlated to the degree of weight loss.Keywords: bariatric surgery, laparoscopic sleeve gastrectomy, growth differentiation factor 15, appetiteSalman AShaaban HEDSalman MM Seif El Nasr SSoliman ASalem ATag El-Din MMikhail HMSEl Domiaty HAbd Allah NGabAllah GMKYoussef ADove Medical Pressarticlebariatric surgerylaparoscopic sleeve gastrectomygrowth differentiation factor 15appetitePathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 14, Pp 1365-1373 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
bariatric surgery laparoscopic sleeve gastrectomy growth differentiation factor 15 appetite Pathology RB1-214 Therapeutics. Pharmacology RM1-950 |
| spellingShingle |
bariatric surgery laparoscopic sleeve gastrectomy growth differentiation factor 15 appetite Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Salman A Shaaban HED Salman M M Seif El Nasr S Soliman A Salem A Tag El-Din M Mikhail HMS El Domiaty H Abd Allah N GabAllah GMK Youssef A Changes in Plasma Growth Differentiation Factor-15 After Laparoscopic Sleeve Gastrectomy in Morbidly Obese Patients: A Prospective Study |
| description |
Ahmed Salman,1 Hossam El-Din Shaaban,2 Mohamed Salman,3 Sayed M Seif El Nasr,1 Ahmed Soliman,1 Abdoh Salem,4 Mohamed Tag El-Din,4 Hani Maurice Sabri Mikhail,3 Heba El Domiaty,5 Nesrin Abd Allah,6 Ghada MK GabAllah,7 Ahmed Youssef1 1Internal Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt; 2Gastroenterology Department, National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt; 3General Surgery Department, Faculty of Medicine, Cairo University, Cairo, Egypt; 4General Surgery Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt; 5Clinical Physiology Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt; 6Anatomy and Embryology Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt; 7Medical Biochemistry Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, EgyptCorrespondence: Ahmed SalmanInternal Medicine Department, Faculty of Medicine, Cairo University, Cairo, EgyptTel +20 1000468664Email awea844@gmail.comPurpose: This study aimed to assess the potential changes of Growth differentiation factor 15 (GDF15) after laparoscopic sleeve gastrectomy (LSG) in morbidly obese patients.Methods: We conducted a prospective study on 68 patients who underwent LSG and 58 cases, who were enrolled as a control group, to whom conservative measures of weight loss were adopted. Both groups were followed for 12 months.Results: At the baseline, the serum GDF15 was comparable between LSG and conservative groups (409.93± 119 versus 385.8± 120.2 pg/mL, p =0.246). However, at 12 months after the operation, the serum GDF15 was significantly higher in the LSG than conservative groups (699.941 ± 193.5 versus 559 ± 159.7; p < 0.001). The degree of serum GDF15 increase was higher in the LSG group (290.01 ± 189.9 versus 173.14 ± 116.7; p < 0.001). The degree of serum GDF15 increase correlated negatively with the final BMI (r = − 0.352, p =0.001) and weight loss (r = − 0.793, p =0.001) at 12 months after the operation. The correlation analysis demonstrated that the initial GFD15 did not correlate with any baseline parameters. Multiple regression analysis of change in serum GDF15 showed a statistical significance of the weight loss after 12 months.Conclusion: The present work confirms the impact of successful weight loss on the circulating level of GDF15. Our study demonstrated that the circulating GDF15 increased significantly after LSG and it was correlated to the degree of weight loss.Keywords: bariatric surgery, laparoscopic sleeve gastrectomy, growth differentiation factor 15, appetite |
| format |
article |
| author |
Salman A Shaaban HED Salman M M Seif El Nasr S Soliman A Salem A Tag El-Din M Mikhail HMS El Domiaty H Abd Allah N GabAllah GMK Youssef A |
| author_facet |
Salman A Shaaban HED Salman M M Seif El Nasr S Soliman A Salem A Tag El-Din M Mikhail HMS El Domiaty H Abd Allah N GabAllah GMK Youssef A |
| author_sort |
Salman A |
| title |
Changes in Plasma Growth Differentiation Factor-15 After Laparoscopic Sleeve Gastrectomy in Morbidly Obese Patients: A Prospective Study |
| title_short |
Changes in Plasma Growth Differentiation Factor-15 After Laparoscopic Sleeve Gastrectomy in Morbidly Obese Patients: A Prospective Study |
| title_full |
Changes in Plasma Growth Differentiation Factor-15 After Laparoscopic Sleeve Gastrectomy in Morbidly Obese Patients: A Prospective Study |
| title_fullStr |
Changes in Plasma Growth Differentiation Factor-15 After Laparoscopic Sleeve Gastrectomy in Morbidly Obese Patients: A Prospective Study |
| title_full_unstemmed |
Changes in Plasma Growth Differentiation Factor-15 After Laparoscopic Sleeve Gastrectomy in Morbidly Obese Patients: A Prospective Study |
| title_sort |
changes in plasma growth differentiation factor-15 after laparoscopic sleeve gastrectomy in morbidly obese patients: a prospective study |
| publisher |
Dove Medical Press |
| publishDate |
2021 |
| url |
https://doaj.org/article/113cb29425a94b2abd57b139389731f1 |
| work_keys_str_mv |
AT salmana changesinplasmagrowthdifferentiationfactor15afterlaparoscopicsleevegastrectomyinmorbidlyobesepatientsaprospectivestudy AT shaabanhed changesinplasmagrowthdifferentiationfactor15afterlaparoscopicsleevegastrectomyinmorbidlyobesepatientsaprospectivestudy AT salmanm changesinplasmagrowthdifferentiationfactor15afterlaparoscopicsleevegastrectomyinmorbidlyobesepatientsaprospectivestudy AT mseifelnasrs changesinplasmagrowthdifferentiationfactor15afterlaparoscopicsleevegastrectomyinmorbidlyobesepatientsaprospectivestudy AT solimana changesinplasmagrowthdifferentiationfactor15afterlaparoscopicsleevegastrectomyinmorbidlyobesepatientsaprospectivestudy AT salema changesinplasmagrowthdifferentiationfactor15afterlaparoscopicsleevegastrectomyinmorbidlyobesepatientsaprospectivestudy AT tageldinm changesinplasmagrowthdifferentiationfactor15afterlaparoscopicsleevegastrectomyinmorbidlyobesepatientsaprospectivestudy AT mikhailhms changesinplasmagrowthdifferentiationfactor15afterlaparoscopicsleevegastrectomyinmorbidlyobesepatientsaprospectivestudy AT eldomiatyh changesinplasmagrowthdifferentiationfactor15afterlaparoscopicsleevegastrectomyinmorbidlyobesepatientsaprospectivestudy AT abdallahn changesinplasmagrowthdifferentiationfactor15afterlaparoscopicsleevegastrectomyinmorbidlyobesepatientsaprospectivestudy AT gaballahgmk changesinplasmagrowthdifferentiationfactor15afterlaparoscopicsleevegastrectomyinmorbidlyobesepatientsaprospectivestudy AT youssefa changesinplasmagrowthdifferentiationfactor15afterlaparoscopicsleevegastrectomyinmorbidlyobesepatientsaprospectivestudy |
| _version_ |
1718390935126016000 |