Annexin-V stabilizes membrane defects by inducing lipid phase transition

Annexins are cytoplasmic proteins, which bind to membranes exposing negatively charged phospholipids in a Ca2+-dependent manner. Here the authors use high-speed atomic force microscopy and other techniques to show that annexin-V self-assembles into highly structured lattices that lead to a membrane...

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Autores principales:	Yi-Chih Lin, Christophe Chipot, Simon Scheuring
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/113cce4b387649e796863951d18e00f7
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spelling	oai:doaj.org-article:113cce4b387649e796863951d18e00f72021-12-02T14:40:53ZAnnexin-V stabilizes membrane defects by inducing lipid phase transition10.1038/s41467-019-14045-w2041-1723https://doaj.org/article/113cce4b387649e796863951d18e00f72020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14045-whttps://doaj.org/toc/2041-1723Annexins are cytoplasmic proteins, which bind to membranes exposing negatively charged phospholipids in a Ca2+-dependent manner. Here the authors use high-speed atomic force microscopy and other techniques to show that annexin-V self-assembles into highly structured lattices that lead to a membrane phase transition on PS-rich membranes.Yi-Chih LinChristophe ChipotSimon ScheuringNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yi-Chih Lin Christophe Chipot Simon Scheuring Annexin-V stabilizes membrane defects by inducing lipid phase transition
description	Annexins are cytoplasmic proteins, which bind to membranes exposing negatively charged phospholipids in a Ca2+-dependent manner. Here the authors use high-speed atomic force microscopy and other techniques to show that annexin-V self-assembles into highly structured lattices that lead to a membrane phase transition on PS-rich membranes.
format	article
author	Yi-Chih Lin Christophe Chipot Simon Scheuring
author_facet	Yi-Chih Lin Christophe Chipot Simon Scheuring
author_sort	Yi-Chih Lin
title	Annexin-V stabilizes membrane defects by inducing lipid phase transition
title_short	Annexin-V stabilizes membrane defects by inducing lipid phase transition
title_full	Annexin-V stabilizes membrane defects by inducing lipid phase transition
title_fullStr	Annexin-V stabilizes membrane defects by inducing lipid phase transition
title_full_unstemmed	Annexin-V stabilizes membrane defects by inducing lipid phase transition
title_sort	annexin-v stabilizes membrane defects by inducing lipid phase transition
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/113cce4b387649e796863951d18e00f7
work_keys_str_mv	AT yichihlin annexinvstabilizesmembranedefectsbyinducinglipidphasetransition AT christophechipot annexinvstabilizesmembranedefectsbyinducinglipidphasetransition AT simonscheuring annexinvstabilizesmembranedefectsbyinducinglipidphasetransition
_version_	1718390095928623104

Annexin-V stabilizes membrane defects by inducing lipid phase transition

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