Numerical simulation of spatiotemporal red blood cell aggregation under sinusoidal pulsatile flow

Abstract Previous studies on red blood cell (RBC) aggregation have elucidated the inverse relationship between shear rate and RBC aggregation under Poiseuille flow. However, the local parabolic rouleaux pattern in the arterial flow observed in ultrasonic imaging cannot be explained by shear rate alo...

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Autores principales:	Cheong-Ah Lee, Dong-Guk Paeng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/113ddddb08b241e7b382e2984e387bfe
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spelling	oai:doaj.org-article:113ddddb08b241e7b382e2984e387bfe2021-12-02T16:58:09ZNumerical simulation of spatiotemporal red blood cell aggregation under sinusoidal pulsatile flow10.1038/s41598-021-89286-12045-2322https://doaj.org/article/113ddddb08b241e7b382e2984e387bfe2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89286-1https://doaj.org/toc/2045-2322Abstract Previous studies on red blood cell (RBC) aggregation have elucidated the inverse relationship between shear rate and RBC aggregation under Poiseuille flow. However, the local parabolic rouleaux pattern in the arterial flow observed in ultrasonic imaging cannot be explained by shear rate alone. A quantitative approach is required to analyze the spatiotemporal variation in arterial pulsatile flow and the resulting RBC aggregation. In this work, a 2D RBC model was used to simulate RBC motion driven by interactional and hydrodynamic forces based on the depletion theory of the RBC mechanism. We focused on the interaction between the spatial distribution of shear rate and the dynamic motion of RBC aggregation under sinusoidal pulsatile flow. We introduced two components of shear rate, namely, the radial and axial shear rates, to understand the effect of sinusoidal pulsatile flow on RBC aggregation. The simulation results demonstrated that specific ranges of the axial shear rate and its ratio with radial shear rate strongly affected local RBC aggregation and parabolic rouleaux formation. These findings are important, as they indicate that the spatiotemporal variation in shear rate has a crucial role in the aggregate formation and local parabolic rouleaux under pulsatile flow.Cheong-Ah LeeDong-Guk PaengNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Cheong-Ah Lee Dong-Guk Paeng Numerical simulation of spatiotemporal red blood cell aggregation under sinusoidal pulsatile flow
description	Abstract Previous studies on red blood cell (RBC) aggregation have elucidated the inverse relationship between shear rate and RBC aggregation under Poiseuille flow. However, the local parabolic rouleaux pattern in the arterial flow observed in ultrasonic imaging cannot be explained by shear rate alone. A quantitative approach is required to analyze the spatiotemporal variation in arterial pulsatile flow and the resulting RBC aggregation. In this work, a 2D RBC model was used to simulate RBC motion driven by interactional and hydrodynamic forces based on the depletion theory of the RBC mechanism. We focused on the interaction between the spatial distribution of shear rate and the dynamic motion of RBC aggregation under sinusoidal pulsatile flow. We introduced two components of shear rate, namely, the radial and axial shear rates, to understand the effect of sinusoidal pulsatile flow on RBC aggregation. The simulation results demonstrated that specific ranges of the axial shear rate and its ratio with radial shear rate strongly affected local RBC aggregation and parabolic rouleaux formation. These findings are important, as they indicate that the spatiotemporal variation in shear rate has a crucial role in the aggregate formation and local parabolic rouleaux under pulsatile flow.
format	article
author	Cheong-Ah Lee Dong-Guk Paeng
author_facet	Cheong-Ah Lee Dong-Guk Paeng
author_sort	Cheong-Ah Lee
title	Numerical simulation of spatiotemporal red blood cell aggregation under sinusoidal pulsatile flow
title_short	Numerical simulation of spatiotemporal red blood cell aggregation under sinusoidal pulsatile flow
title_full	Numerical simulation of spatiotemporal red blood cell aggregation under sinusoidal pulsatile flow
title_fullStr	Numerical simulation of spatiotemporal red blood cell aggregation under sinusoidal pulsatile flow
title_full_unstemmed	Numerical simulation of spatiotemporal red blood cell aggregation under sinusoidal pulsatile flow
title_sort	numerical simulation of spatiotemporal red blood cell aggregation under sinusoidal pulsatile flow
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/113ddddb08b241e7b382e2984e387bfe
work_keys_str_mv	AT cheongahlee numericalsimulationofspatiotemporalredbloodcellaggregationundersinusoidalpulsatileflow AT donggukpaeng numericalsimulationofspatiotemporalredbloodcellaggregationundersinusoidalpulsatileflow
_version_	1718382370945499136

Numerical simulation of spatiotemporal red blood cell aggregation under sinusoidal pulsatile flow

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