Association between metabolic syndrome components and the risk of developing nephrolithiasis: A systematic review and bayesian meta-analysis [version 1; peer review: 2 approved]

Background: There is increasing evidence that nephrolithiasis is a systemic disease, as opposed to an isolated urinary metabolic problem, after considerable links were found between nephrolithiasis and systemic diseases such as hypertension, obesity, dyslipidemia, and insulin resistance. The interpl...

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Autores principales:	Ilham Akbar Rahman, Ilham Fauzan Nusaly, Syakri Syahrir, Harry Nusaly, Makbul Aman Mansyur
Formato:	article
Lenguaje:	EN
Publicado:	F1000 Research Ltd 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/11428e3311a340e68a19b450109ad906
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spelling	oai:doaj.org-article:11428e3311a340e68a19b450109ad9062021-11-15T15:26:10ZAssociation between metabolic syndrome components and the risk of developing nephrolithiasis: A systematic review and bayesian meta-analysis [version 1; peer review: 2 approved]2046-140210.12688/f1000research.28346.1https://doaj.org/article/11428e3311a340e68a19b450109ad9062021-02-01T00:00:00Zhttps://f1000research.com/articles/10-104/v1https://doaj.org/toc/2046-1402Background: There is increasing evidence that nephrolithiasis is a systemic disease, as opposed to an isolated urinary metabolic problem, after considerable links were found between nephrolithiasis and systemic diseases such as hypertension, obesity, dyslipidemia, and insulin resistance. The interplay between these four factors defines metabolic syndrome (MetS). In this review we aim to clarify the associations of MetS and its components to kidney stone incident. Methods: Online databases of EMBASE, MEDLINE, and Google Scholar were searched from January 1998 up to October 2020 to identify observational studies examining the association between metabolic syndrome components and kidney stone incident. Bayesian random-effects meta-analysis and meta-regression were performed to observe the association. Linear dose-response analysis was conducted to shape the direction of the association. Data analysis was performed using STATA, and R statistics. Results: A total of 25 potentially relevant studies (n = 934,588 participants) were eventually identified. The pooled results suggested that metabolic syndrome was associated with an increased risk of nephrolithiasis with an odds ratio (OR) of 1.769 (95% CI: 1.386 – 2.309). The summary OR of hypertension and dyslipidemia for developing nephrolithiasis were 1.613 (95% CI: 1.213 – 2.169) and 1.586 (95% CI: 1.007 – 2.502) respectively. The presence of diabetes mellitus and obesity had an OR of 1.552 (95% CI: 1.027 – 2.344) and 1.531 (95% CI: 1.099 – 2.109) respectively. Our results revealed that the increasing number of MetS traits will increase the risk of developing nephrolithiasis, the higher the fasting plasma glucose, and body mass index, the higher the risk of kidney stones incident. Conclusions: Our results suggest that hypertension, diabetes, obesity and dyslipidemia are associated with increased risk of developing nephrolithiasis. Linear significant association between MetS components and nephrolithiasis were revealed in our study which reinforced the notion that should be considered a systemic disorder.Ilham Akbar RahmanIlham Fauzan NusalySyakri SyahrirHarry NusalyMakbul Aman MansyurF1000 Research LtdarticleMedicineRScienceQENF1000Research, Vol 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ilham Akbar Rahman Ilham Fauzan Nusaly Syakri Syahrir Harry Nusaly Makbul Aman Mansyur Association between metabolic syndrome components and the risk of developing nephrolithiasis: A systematic review and bayesian meta-analysis [version 1; peer review: 2 approved]
description	Background: There is increasing evidence that nephrolithiasis is a systemic disease, as opposed to an isolated urinary metabolic problem, after considerable links were found between nephrolithiasis and systemic diseases such as hypertension, obesity, dyslipidemia, and insulin resistance. The interplay between these four factors defines metabolic syndrome (MetS). In this review we aim to clarify the associations of MetS and its components to kidney stone incident. Methods: Online databases of EMBASE, MEDLINE, and Google Scholar were searched from January 1998 up to October 2020 to identify observational studies examining the association between metabolic syndrome components and kidney stone incident. Bayesian random-effects meta-analysis and meta-regression were performed to observe the association. Linear dose-response analysis was conducted to shape the direction of the association. Data analysis was performed using STATA, and R statistics. Results: A total of 25 potentially relevant studies (n = 934,588 participants) were eventually identified. The pooled results suggested that metabolic syndrome was associated with an increased risk of nephrolithiasis with an odds ratio (OR) of 1.769 (95% CI: 1.386 – 2.309). The summary OR of hypertension and dyslipidemia for developing nephrolithiasis were 1.613 (95% CI: 1.213 – 2.169) and 1.586 (95% CI: 1.007 – 2.502) respectively. The presence of diabetes mellitus and obesity had an OR of 1.552 (95% CI: 1.027 – 2.344) and 1.531 (95% CI: 1.099 – 2.109) respectively. Our results revealed that the increasing number of MetS traits will increase the risk of developing nephrolithiasis, the higher the fasting plasma glucose, and body mass index, the higher the risk of kidney stones incident. Conclusions: Our results suggest that hypertension, diabetes, obesity and dyslipidemia are associated with increased risk of developing nephrolithiasis. Linear significant association between MetS components and nephrolithiasis were revealed in our study which reinforced the notion that should be considered a systemic disorder.
format	article
author	Ilham Akbar Rahman Ilham Fauzan Nusaly Syakri Syahrir Harry Nusaly Makbul Aman Mansyur
author_facet	Ilham Akbar Rahman Ilham Fauzan Nusaly Syakri Syahrir Harry Nusaly Makbul Aman Mansyur
author_sort	Ilham Akbar Rahman
title	Association between metabolic syndrome components and the risk of developing nephrolithiasis: A systematic review and bayesian meta-analysis [version 1; peer review: 2 approved]
title_short	Association between metabolic syndrome components and the risk of developing nephrolithiasis: A systematic review and bayesian meta-analysis [version 1; peer review: 2 approved]
title_full	Association between metabolic syndrome components and the risk of developing nephrolithiasis: A systematic review and bayesian meta-analysis [version 1; peer review: 2 approved]
title_fullStr	Association between metabolic syndrome components and the risk of developing nephrolithiasis: A systematic review and bayesian meta-analysis [version 1; peer review: 2 approved]
title_full_unstemmed	Association between metabolic syndrome components and the risk of developing nephrolithiasis: A systematic review and bayesian meta-analysis [version 1; peer review: 2 approved]
title_sort	association between metabolic syndrome components and the risk of developing nephrolithiasis: a systematic review and bayesian meta-analysis [version 1; peer review: 2 approved]
publisher	F1000 Research Ltd
publishDate	2021
url	https://doaj.org/article/11428e3311a340e68a19b450109ad906
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Association between metabolic syndrome components and the risk of developing nephrolithiasis: A systematic review and bayesian meta-analysis [version 1; peer review: 2 approved]

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